Patents
Universal donor cells
Patent Number: 5705732This patent covers manipulated cells and stem cells that are not immunogeneic when inplanted into a recipient. Various means of reducing immunogenecity are disclosed such as expression of human complement inhibitors and deletion or suppression of MHC expression.
Inventors: Sims, Peter J. (Mequon, WI); Bothwell, Alfred L.M. (Guilford, CT); Elliot, Eileen A. (New Haven, CT); Flavell, Richard A. (Killingworth, CT); Madri, Joseph (North Branford, CT); Rollins, Scott (Monroe, CT); Bell, Leonard (Woodbridge, CT); Squinto, Stephen
Assignee: Oklahoma Medical Research Foundation (Oklahoma City, OK); Yale University (New Haven, CT)
Date of First Priority Issue: Monday June 12th, 1989
Use of interleukin-7 to stimulate proliferation of hematopoietic cell precursors
Patent Number: 5705149This patent covers the use of IL-7 to stimulate hematopoiesis.
Inventors: Namen, Anthony E. (Seattle, WA); Goodwin, Raymond G. (Seattle, WA); Lupton, Stephen D. (Seattle, WA); Mochizuki, Diane Y. (Seattle, WA)
Assignee: Sterling Winthrop Inc. (New York, NY)
Date of First Priority Issue: Monday October 26th, 1987
Method for the preparation of in vitro-derived human neutrophil precursor cells
Patent Number: 5700691This patent teaches how to differentiate hematopoietic stem cells into a type of stem cell that is committed to the neutrophil lineage. These "committed" stem cells may be administered into a neutropenic patient until endogenous neutrophils rebound.
Inventors: Bender, James G. (Lindenhurst, IL); Maples, Phillip B. (Waukegan, IL); Smith, Stephen (Arlington Heights, IL); Unverzagt, Kristen L. (Palatine, IL); Van Epps, Dennis E. (Cary, IL)
Assignee: Baxter Healthcare Inc. (Irvine, CA)
Date of First Priority Issue: Monday March 23rd, 1992
Tissue-engineered bone repair using cultured periosteal cells
Patent Number: 5700289This patent teaches that in some situations, cells from the periosteum can be grown and used as a "stem cell like" population for the treatment of bone defects.
Inventors: Breitbart, Arnold S. (Great Neck, NY); Grande, Daniel A. (Sea Cliff, NY)
Assignee: North Shore University Hospital Research Corporation (Manhasset, NY)
Date of First Priority Issue: Friday October 20th, 1995
Submucosa as a growth substrate for islet cells
Patent Number: 5695998This patent teaches that submucosa matrix proteins are useful for expanding islet cells in vitro. This technology may allow the use of pancreatic stem cells to generate large amounts of islets for treatment of patients with Type 1 diabetes.
Inventors: Badylak, Stephen F. (W. Lafayette, IN); Boder, George (Martinsville, IN); Voytik, Sherry (Lafayette, IN); Demeter, Robert J. (Mooresville, IN); Critser, John (Carmel, IN); Liu, Chi (Indianapolis, IN)
Assignee: Purdue Research Foundation (West Lafayette, IN); Methodist Hospital of Indiana, Inc. (Indianapolis, IN)
Date of First Priority Issue: Friday February 10th, 1995
Neurogenic differentiation (neurod) genes
Patent Number: 5695995This patent teaches specific gene sequences that transcribe proteins which induce differentiation of stem cells into neurons.
Inventors: Weintraub, deceased, Harold M. (late of Seattle, WA); Lee, Jacqueline E. (Denver, CO); Hollenberg, Stanley M. (Portland, OR); Tapscott, Stephen J. (Seattle, WA)
Assignee: Fred Hutchinson Cancer Research Center (Seattle, WA)
Date of First Priority Issue: Friday May 6th, 1994
Peripheralization of hematopoietic stem cells
Patent Number: 5695755This patent covers mobilization of hematopoietic stem cells by administration of antibodies to VCAM or VLA-4.
Inventor: Papayannopoulou, Thalia (Seattle, WA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday November 13th, 1992
Methods and reagents for lengthening telomeres
Patent Number: 5686306This patent provides compositions of matter, specifically peptide targets for telomerase, which allow for enhanced telomerase activity and longer cellular life span.
Inventors: West, Michael D. (San Carlos, CA); Shay, Jerry (Dallas, TX); Wright, Woodring E. (Arlington, TX)
Assignee: Board of Regents, The University of Texas System (Austin, TX)
Date of First Priority Issue: Wednesday May 13th, 1992
Growth of pancreatic islet cells
Patent Number: 5681587This patent teaches how to expand islets as much as 1000 fold !! This is performed through culture of islet stem cells in laminin 5, and other substrates derived from cell lines that are provided in the patent. This patent may be useful to stem cell companies that are currently generating islets from of a variety of stem cell sources.
Inventors: Halberstadt, Craig (San Diego, CA); Zimber, Michael (Pullman, WA); Grzesiak, John J. (Cardiff, CA)
Assignee: Desmos, Inc. (San Diego, CA)
Date of First Priority Issue: Friday March 29th, 1996
Method for producing a highly enriched population of hematopoietic stem cells
Patent Number: 5681559This patent teaches the extraction of hematopoietic stem cells from fetal sources. It may be that these stem cells have more potent repopulating activity as compared to stem cells from sources.
Inventors: DiGiusto, David (Palo Alto, CA); Galy, Anne (Palo Alto, CA)
Assignee: Systemix, Inc. (Palo Alto, CA)
Date of First Priority Issue: Wednesday August 25th, 1993