Patents
Mammalian neural crest stem cells
Patent Number: 5589376This patent covers a type of neural stem cell that is derived from the neural crest and expresses a specific phenotypic profile that allows not only for isolation, but also in vitro and in vivo identification. This stem cell type is capable of differentiating into neurons similar to those found in the peripheral nervious system, as well as microglia. The cell has a phenotype of LNGFR...
Inventors: Anderson, David J. (Altadena, CA); Stemple, Derek L. (Pasadena, CA)
Assignee: California Institute of Technology (Pasadena, CA)
Date of First Priority Issue: Monday July 27th, 1992
T lymphocyte precursor
Patent Number: 5583033This patent covers the stem cell that gives rise to T cells. The claims actually comprise methods of isolation of a precursor that is CD34+, Leu8+ and CD7+. This patent is useful not only for purifying T cell stem cells for ex vivo growth and expansion, but also for identifying the T cell precursor pool in patients with various diseases.
Inventors: Terstappen, Leon W. M. M. (Palo Alto, CA); Picker, Louis J. (Dallas, TX)
Assignee: Becton Dickinson and Company (Franklin Lakes, NJ)
Date of First Priority Issue: Tuesday May 1st, 1990
Methods of treating bacterial inflammation and granulocytopoiesis by administering human pluripotent granulocyte colony-stimulating factor
Patent Number: 5582823This patent covers the use of human pluripotent granulocyte colony stimulating factor for induction of granulocyte production, as well as for reducing bacterially mediated inflammation. The use of growth factors such as the one described has expanded in recent years to other types of stem cells besides hematopoietic stem cells. It will be interesting to see first what the new name for the...
Inventor: Souza, Lawrence M. (Thousand Oaks, CA)
Assignee: Amgen Inc. (Thousand Oaks, CA)
Date of First Priority Issue: Friday August 23rd, 1985
Generation of neural precursor cell lines
Patent Number: 5580777This patent covers neural stem cells that have been immortalized with c-myc or n-myc. These cells are useful not only for in vitro study and drug discovery, but also for therapy if differentiated properly so as to not possess malignant potential. The owner of the patent, Amrad, possesses numerous powerful patents in the area of stem cells.
Inventors: Bernard, Ora (North Balwyn, AU); Bartlett, Perry F. (North Carlton, AU)
Assignee: Amrad Corporation Limited (AU)
Date of First Priority Issue: Wednesday December 28th, 1988
Human pluripotent granulocyte colony-stimulating factor
Patent Number: 5580755This patent covers a growth factor called human pluripotent granulocyte colony stimulating factor. Since names of growth factors have been standardized, it is difficult to tell which modern-day cytokine this is referring to. In any case, this growth factor is an expander of hematopoietic stem cells, and is useful for treatment of patients whose hematopoietic system has been minimized either...
Inventor: Souza, Lawrence M. (Thousand Oaks, CA)
Assignee: Amgen Inc. (Thousand Oaks, CA)
Date of First Priority Issue: Friday August 23rd, 1985
Differential expansion of fetal stem cells in maternal circulation for use in prenatal genetic analysis
Patent Number: 5580724This patent teaches how to expand fetal cells found in the maternal blood so as to be able to perform genetic tests without the need for amniocentesis. Since some have reported fetal stem cells in maternal circulation, it may be possible to use the technique in this patent, or a variation thereof, for obtaining fetal stem cells at various stages of development.
Inventor: Alter, Blanche P. (Galveston, TX)
Assignee: Board of Regents, The University of Texas System (Austin, TX)
Date of First Priority Issue: Friday March 25th, 1994
Homologous recombination for universal donor cells and chimeric mammalian hosts
Patent Number: 5574205This patent covers generation of mice that lack MHC I and/or MHC II. Stem cell transplants are one of the transplants that the inventor believes can be performed with donor cells that lack MHC I and/or MHC II. Unfortunately the issue of rejection has to do not only with "major" histoincompatibility, but also with "minor" histoincompatibility.
Inventors: Kucherlapati, Raju (Darien, CT); Koller, Beverly H. (Carrboro, NC); Smithies, Oliver (Chapel Hill, NC); Dubridge, Robert B. (Belmont, CA); Greenburg, Gary (San Carlos, CA); Capon, Daniel J. (Hillsborough, CA); Williams, Steven R. (San Francisco, CA); De R
Assignee: Cell Genesys (Foster City, CA)
Date of First Priority Issue: Tuesday July 25th, 1989
Liver reserve cells
Patent Number: 5559022Liver stem cells are very interesting to study, in part because of the very potent regenerative ability of the liver. In this patent a type of liver stem cell is claimed called the "liver reserve cell". These cells are characterized by ability to be stained by methylene blue and Azure A, adherence, multinucleation, ability to differentated, and specific density on percoll.
Inventors: Naughton, Brian A. (El Cajon, CA); Sibanda, Benson (Oceanside, CA)
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Friday October 9th, 1992
Hematopoietic stem cell specific gene expression
Patent Number: 5556954This patent covers the promoter for CD34. CD34 is a classical marker of stem cells, not only of the hematopoietic type but also of the hepatic type. CD34 is highly glycosylated and acts as an adhesion molecule. Mice that are knocked out for CD34 still have hematopoiesis, however the stem cells to not migrate properly. The current patent can be used for many things, including placing...
Inventors: Burn, Timothy C. (Bedford, MA); Satterthwaite, Anne B. (Brighton, MA); Tenen, Daniel G. (Boston, MA)
Assignee: Beth Israel Hospital Boston Association (Boston, MA)
Date of First Priority Issue: Thursday February 13th, 1992
Methods of culturing and modulating the growth of hair follicular stem cells
Patent Number: 5556783This patent covers methods of expanding stem cells derived from the hair follicle. One of the methods of expanding hair follicle stem cells is through growing then on 3T3 fibroblasts. Hair stem cells are somewhat similar to mesenchymal stem cells and may be useful for a wide variety of applications in addition to
Assignee: Trustees of Univ. of Penna (Philadelphia, PA); New York Univ. (New York, NY)
Date of First Priority Issue: Wednesday March 27th, 1991