Patents
Hemoregulatory peptides
Patent Number: 5620957This patent provides novel compositions of matter for stimulation of hematopoietic stem cells. This patent is useful for post chemotherapy and post radiation therapy stimulation of blood cell production. It may be useful for stimulation of other stem cells as well, including for stimulation of endothelial precursors and angiogenesis.
Inventors: Bhatnagar, Pradip K. (Exton, PA); Huffman, William F. (Malvern, PA); Talmadge, James E. (Bellevue, NE)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Date of First Priority Issue: Friday July 14th, 1989
Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
Patent Number: 5612211This patent covers the expansion of hematopoietic stem cells, both in vitro and in vivo with fibroblast growth factors. This patent is important not only for stimulation of post-ablation hematopoiesis, but can also be used to cover angiogenesis stimulation by fibroblast growth factors since angiogenesis involves hematopoietic stem cells, at least in some embodiments.
Inventors: Wilson, Elaine L. (New York, NY); Gabrilove, Janice (New York, NY)
Assignee: New York University (New York, NY); Sloan-Kettering Institute For Cancer Research (New York, NY)
Date of First Priority Issue: Monday January 8th, 1990
Retrovirus infecting primate bone marrow cells and harvesting both non-adherent and adherent cells
Patent Number: 5612206This patent covers transfection of primate bone marrow cells with genes that that gene therapy may be used. The patent provides amphotropic retroviral vectors for transfection of the bone marrow.
Inventors: Valerio, Domenico (Leiden, NL); van Beusechem, Victor W. (Amsterdam, NL)
Assignee: Introgene B.V. (NL)
Date of First Priority Issue: Friday October 4th, 1991
Method of regenerating or replacing cartilage tissue using amniotic cells
Patent Number: 5612028This patent teaches the use of stem cells derived from amniotic tissue for regeneration of cartilage tissue. The stem cells of the amniotic tissue claimed are epithelial and free of mesenchymal tissue.
Inventors: Sackier, Jonathan M. (Surrey, GB3); Wood, Christopher B. (Buckinghamshire, GB3); Krishnan, Rajagopallan (Surrey, GB3); Wiggington, Gordon R. (Hampshire, GB3); Butler, Douglas Mitchel H. (Surrey, GB3)
Assignee: Genethics Limited (Surrey, GB)
Date of First Priority Issue: Wednesday February 17th, 1988
Double chain peptide compounds having hemoregulatory activity
Patent Number: 5610141This patent is a composition of matter patent covering a novel peptide that has ability to stimulate bone marrow proliferation and hematopoiesis. This is a very useful patent for pharmaceutical development since there is a need in the art for agents with good pharmacokinetics that stimulate hematopoiesis.
Inventors: Undheim, Kjell (Sandvika, NO); Solbakken, Magne (Oslo, NO); Agner, Erik (Oslo, NO); Kremminger, Peter (Linz, AT); Lange, Meinolf (Oslo, NO)
Assignee: Nycomed Imaging AS (NO)
Date of First Priority Issue: Tuesday June 2nd, 1992
Use of stem cell factor interleukin-6 and soluble interleukin-6 receptor to induce the development of hematopoietic stem cells
Patent Number: 5610056This patent teaches that administration of stem cell factor, IL6, and IL6 soluble receptor, to hematopoietic stem cells, causes the hematopoietic stem cells to differentiate into erythroid precursors, and into erythrocytes. This patent is useful for parties seeking to generate red blood cells in vitro.
Inventor: Nakahata, Tatsutoshi (Tokyo, JP)
Assignee: Amgen Inc. (Thousand Oaks, CA); Tosoh Corporation (Tokyo, JP)
Date of First Priority Issue: Wednesday November 16th, 1994
Stroma-derived stem cell proteoglycan growth factor
Patent Number: 5605829This patent provides a novel composition of matter that is useful for expansion of hematopoietic stem cells in vitro. The composition of matter is a unique proteoglycan that can selectively enhance the numbers of CD34+ stem cells when added to various in vitro culture systems.
Inventors: McGlave, Philip B. (St. Paul, MN); Verfaillie, Catherine M. (St. Paul, MN); Gupta, Pankaj (Minneapolis, MN)
Assignee: Regents of the University of Minnesota (Minneapolis, MN)
Date of First Priority Issue: Friday November 12th, 1993
Methods, compositions and devices for growing human hematopoietic cells
Patent Number: 5605822This patent teaches culture systems for growing and expanding hematopoietic stem cells. The culture system consists of a gene-transfected stromal layer that produces growth factors, as well as a continuous perfusion system which allows media to pass over the cells.
Inventors: Emerson, Stephen G. (Ann Arbor, MI); Clarke, Michael F. (Ann Arbor, MI); Palsson, Bernhard O. (Ann Arbor, MI)
Assignee: The Regents of The University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Sunday January 15th, 1989
Protection of hemopoietic cells during chemotherapy or radiotherapy
Patent Number: 5595973This patent is useful in the treatment of patients with radiation or chemotherapy. Since hematopoietic stem cell toxicity is usually the dose limiting factor in radiation or chemotherapy, this patent teaches a way how to overcome this. Specifically, the patent claims inhibiting hematopoietic stem cell proliferation through administration of AcSDKP, then providing the chemotherapy and/or...
Inventor: Bogden, Arthur E. (Hopedale, MA)
Assignee: Biomeasure Incorporated (Milford, MA)
Date of First Priority Issue: Wednesday September 21st, 1994
Transduced mesenchymal stem cells
Patent Number: 5591625This patent covers mesenchymal stem cells that are transfected with anything. Mesenchymal stem cells are very useful for clinical development since that do not need to be matched with HLA of the recipient in many situations, thus allowing for the use of an "off the shelf" product. The advantage of transfecting mesenchymal stem cells with genes is that the mesenchymal stem cells can act as a...
Inventors: Gerson, Stanton L. (Pepper Pike, OH); Caplan, Arnold I. (Cleveland Heights, OH); Haynesworth, Stephen E. (Cleveland Heights, OH)
Assignee: Case Western Reserve University (Cleveland, OH)
Date of First Priority Issue: Wednesday November 24th, 1993