Patents
Method for implanting encapsulated cells in a host
Patent Number: 5550050Microencapsulation allows delivery of immunologically incompatible cells to a recipient. The technology of microencapsulation has been used clinically for a variety of uses, including administration of cell therapy ranging from neurons to islets. The use of embryonic stem cells may require encapsulation so has to not only overcome the allogeneic barriers, but also to prevent growth and...
Inventors: Holland, Laura M. (Providence, RI); Hammang, Joseph P. (Barrington, RI); Rudnick, Seth A. (Barrington, RI); Lysaght, Michael J. (E. Greenwich, RI); Dionne, Keith E. (Rehoboth, MA)
Assignee: CytoTherapeutics, Inc. (Providence, RI)
Date of First Priority Issue: Friday April 15th, 1994
Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
Patent Number: 5549674This patent covers an artificial kidney system designed in a manner so as to combine hollow fiber technology with living, fresh endothelial cells. This patent does mention that in some embodiments stem cells may be used for providing the necessary cells. Various artificial kidneys have been designed and the author of this patent has actually been involved in their clinical development...
Inventors: Humes, H. David (Ann Arbor, MI); Cieslinski, Deborah A. (Ann Arbor, MI)
Assignee: The Regents of The University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Monday March 2nd, 1992
Three-dimensional bone marrow cell and tissue culture system
Patent Number: 5541107In this patent regarding bone marrow stem cell culture, Advanced Tissue Sciences continues their tour de force in three dimensional culture IP, through covering the use of three dimensional cultures for expanding bone marrow stem cells. Specifically, the patent teaches that stromal cells and a three dimensional matrix can be used for expansion of hematopoietic stem cell.
Inventors: Naughton, Gail K. (Groton, VT); Naughton, Brian A. (Groton, VT)
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Friday April 18th, 1986
Inducing granulocyte production or B cell production in peripheral blood by TGF-.beta.
Patent Number: 5529982TGF-beta is a cytokine with numerous anti-inflammatory functions. The importance of TGF-beta at controlling inflammation is seen not only in its ability to prevent autoimmunity in several animal models, but also by the fact that tumor cells secrete large quantities of it in order to escape immune-mediated killing. This patent teaches that TGF-beta can be administered in order to stimulate...
Inventors: Carlino, Joseph (San Leandro, CA); Singh, Naina (Santa Clara, CA); Ellingsworth, Larry (San Jose, CA)
Assignee: Celtrix Pharmaceuticals, Inc. (Santa Clara, CA)
Date of First Priority Issue: Tuesday August 6th, 1985
Treatment of immunologic and hematologic disorders with IGFBP alone or complexed with IGF
Patent Number: 5527776This patent teaches that IGF-1 together with IGF Binding Protein-3 (IGFBP-3) can be used for stimulation of hematopoiesis and specifically upregulation of erythroid production in anemic patients. This is one example of a patent covering compounds that are traditionally seen as in the domain of endocrinologists, that are applied to hematology for new uses. The importance of IGF+IGFBP3 in...
Inventors: Carlino, Joseph A. (San Leandro, CA); Higley, Howard R. (Mountain View, CA); Maack, Christopher A. (El Cerrito, CA)
Assignee: Celtrix Pharmaceuticals
Date of First Priority Issue: Monday September 20th, 1993
Stroma-derived proteoglycan containing composition which promotes differentiation and maintains the self-renewal capacity of long-term bone marrow culture-initiating cells
Patent Number: 5523286This patent provides a proteoglycan matrix that can be used for growth and expansion of hematopoietic stem cells. Interestingly this patent promotes not just growth of CD34+ hematopoietic stem cells, but specifically, hematopoietic stem cells that are capable of supporting long term cultures. This patent can be used for expanding hematopoietic stem cells for autologous bone marrow...
Inventors: McGlave, Philip B. (St. Paul, MN); Verfaillie, Catherine M. (St. Paul, MN)
Assignee: Regents of the University of Minnesota (Minneapolis, MN)
Date of First Priority Issue: Friday November 12th, 1993
Three-dimensional pancreatic cell and tissue culture system
Patent Number: 5516681This patent teaches the use of stromal cells to support growth, proliferation, and differentiation of islet-like pancreatic structures after addition of pancreatic acinar cells to the culture. This technology can be a great basis for the numerous other stem cell technologies currrently available for islet regeneration.
Inventors: Naughton, Gail K. (Groton, VT); Naughton, Brian A. (Groton, VT)
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Friday April 18th, 1986
Three-dimensional kidney cell and tissue culture system
Patent Number: 5516680This patent teaches the generation of artificial kidneys through culturing of various cells that comprise the functional kidney in a three dimensional stromal preparation. The patent may be used not only for addition of kidney stem cells, but can incorporate various types of adult and embryonic stem cells for generation of "younger" kidneys.
Inventors: Naughton, Gail K. (Groton, VT); Naughton, Brian A. (Groton, VT)
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Friday April 18th, 1986
Three-dimensional skin cell and tissue culture system
Patent Number: 5512475This patent teaches how to generate artificial skin through culturing of stem cells in a three dimensional matrix. Artificial skin is very useful not only for burn patients, but also for in vitro testing of topical drug formulations. The invention uses a stromal cell preparation onto which melanocytes and keratinocytes are added.
Inventors: Naughton, Gail K. (Groton, VT); Naughton, Brian A. (Groton, VT)
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Friday April 18th, 1986
Megakaryocyte potentiator
Patent Number: 5498698This patent discloses a protein that stimulates production of platelets. This protein may be similar to thrombopoietin and should be investigated further.
Inventors: Yamaguchi, Nozomi (Kyoto, JP); Oh-Eda, Masayoshi (Shizuoka, JP); Hattori, Kunihiro (Shizuoka, JP)
Assignee: Chugai Seiyaku Kabushiki Kaisha (JP)
Date of First Priority Issue: Friday December 27th, 1991