Patents
Method for producing non-neoplastic, three dimensional, mammalian tissue and cell aggregates under microgravity culture conditions and the products produced therefrom
Patent Number: 5496722This patent teaches the generation of three dimensional tissues through culture under microgravity conditions. This patent discloses several culture conditions, as well as scaffolds, that can be utilized for the generation of the three dimensional organ or organoid structure.
Inventors: Goodwin, Thomas J. (Friendswood, TX); Wolf, David A. (Houston, TX); Spaulding, Glenn F. (Houston, TX); Prewett, Tacey L. (Friendswood, TX)
Assignee: The United States of America as represented by the Administrator of the (Washington, DC)
Date of First Priority Issue: Thursday June 30th, 1988
Parthenogenic oocyte activation
Patent Number: 5496720Parthenogenesis comes from Greece and essentially means "virgin birth". This patent teaches how to induce parthenogenesis in a bovine oocyte through induction of calcium flux. The induction of parthenogenesis leads to activation of the oocyte and can be used as a method of generating autologous stem cells for woman.
Inventors: Susko-Parrish, Joan L. (Monona, WI); Northey, David L. (Middleton, WI); Leibfried-Rutledge, M. Lorraine (Madison, WI); Stice, Steven L. (DeForest, WI)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday February 10th, 1993
Use of neutral soluble glucan preparations to stimulate platelet production
Patent Number: 5488040beta.(1-3) glucan is used clinically as an immune stimulator. This patent teaches that beta glucan can be used to stimulate production of platelets by acting at the level of the hematopoietic stem cell. Beta glucan's mechanism of doing this appears to be currently unknown. Given the wide availablity and safety profile of beta glucan, this patent is useful for clinical development if proper...
Inventors: Jamas, Spiros (Boston, MA); Easson, Jr., D. Davidson (Shrewsbury, MA); Ostroff, Gary R. (Worcester, MA)
Assignee: Alpha-Beta Technology, Inc. (Worcester, MA)
Date of First Priority Issue: Friday September 8th, 1989
Human mesenchymal stem cells
Patent Number: 5486359Mesenchymal stem cells are propably the most advanced in terms of clinical development of all stem cell types, second only to bone marrow stem cell. This patent covers mesenchymal stem cells in general. Specifically a cell is claimed that is positive for the markers SH2, SH3, and SH4. The claimed cell is capable of differentiating into connective tissue. Mesenchymal stem cells are very...
Inventors: Caplan, Arnold I. (Cleveland Heights, OH); Haynesworth, Stephen E. (Cleveland Heights, OH)
Assignee: Osiris Therapeutics, Inc. (Cleveland, OH)
Date of First Priority Issue: Friday November 16th, 1990
Peptide compounds which inhibit the proliferation of epidermal or epithelial stem cells
Patent Number: 5484770This patent discloses peptides that specifically inhibit proliferation of epidermal and/or epithelial stem cells. On the one hand this patent is useful for protection of such stem cells when the patient is treated with a cytotoxic agent that targets proliferating cells, such as in the case of cancer therapy. On the other hand, this patent may be used in combination with other patents or...
Inventor: Laerum, Ole D. (Sandviken, NO)
Assignee: Hafslund Nycomed Bioreg AS (Oslo, NO)
Date of First Priority Issue: Friday September 16th, 1988
Method for culturing T precursor cells under conditions of high oxygen concentration
Patent Number: 5476780The stem cells that generate T cells originate in the bone marrow and differentiate in the thymus. This patent teaches that T cell precursors can be expanded in high oxygen conditions in a thymic-like microenvironment. This patent is very interesting not only from the point of view of generating T cells for immune stimulation, but also because theoretically it can be applied to the generation of...
Inventor: Watanabe, Yoshihiro (Yokohama, JP)
Assignee: Japan Tobacco, Inc. (Tokyo, JP)
Date of First Priority Issue: Thursday July 4th, 1991
Satellite cell proliferation in adult skeletal muscle
Patent Number: 5466676This patent teaches methods of transfecting various stem cells with therapeutic or marker genes. Particularly, muscle stem cells, called satellite cells are discussed as target cells suitable for transfection.
Inventors: Booth, Frank W. (Houston, TX); Thomason, Donald B. (Memphis, TN); Morrison, Paul R. (Indianapolis, IN); Stancel, George M. (Houston, TX)
Assignee: Board of Regents, The University of Texas at Austin (
Date of First Priority Issue: Monday February 12th, 1990
Purification and manipulation of bone marrow and blood cells on the basis of P-glycoprotein expression
Patent Number: 5464753This patent teaches that stem cells have an active efflux mechanism similar to the way that cancer cells have an efflux mechanism that makes them drug resistant. The only question about this patent is whether it also covers stem cells that are already identified using other markers. For example, it is very likely that the stem cells, at least hematopoietic stem cells that possess the efflux...
Inventors: Chaudhary, Preet M. (Chicago, IL); Roninson, Igor B. (Chicago, IL)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday March 8th, 1991
Osteogenic growth polypeptides identified from regenerating bone marrow
Patent Number: 5461034This patent covers a composition of matter (peptide) that is derived from bone marrow, that stimulates bone formation. The peptide may be useful for healing through stimulation of endogenous stem cells, as well as through administration in combination with a stem cell source so as to accelerate bone healing.
Inventors: Rodan, Gideon A. (Bryn Mawr, PA); Jacobs, John W. (Irvine, CA); Sardana, Mohinder K. (Lansdale, PA); Gazit, Dan (Jerusalem, IL); Chorev, Michael (Jerusalem, IL); Muhlrad, Andras (Jerusalem, IT); Shteyer, Arye (Jerusalem, IL); Mansur, Nura (Jerusalem, IL);
Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem (Jerusalem, IL)
Date of First Priority Issue: Thursday February 23rd, 1989
Method for culturing hematopoietic cells
Patent Number: 5460964This patent teaches the culture of hematopoietic stem cells in a manner that the cells do not adhere to the stromal cells that provide various trophic growth factors. IL-3 and MIP-1 alpha are also covered for use in the hematopoietic stem cell culture system described herein.
Inventors: McGlave, Philip B. (St. Paul, MN); Verfaillie, Catherine M. (St. Paul, MN); Miller, Jeffrey S. (Little Canada, MN)
Assignee: Regents of the University of Minnesota (Minneapolis, MN)
Date of First Priority Issue: Friday April 3rd, 1992