Patents
Methods for use of mpl ligands with primitive human stem cells
Patent Number: 6916470The mpl ligand, also known as thrombopoietin, is important for stimulation of platelet production from hematopoietic stem cells. Thrombopoietin, in addition to shifting differentiation towards the megakaryocytic lineage, also has some ability to induce proliferation of early hematopoietic stem cells. This patent uses the ability of thrombopoietin to stimulate stem cell proliferation in order...
Inventors: Murray, Lesley J. (San Jose, CA); Young, Judy C. (Mountain View, CA)
Assignee: Novartis AG (Basel, CH)
Date of First Priority Issue: Monday October 30th, 1995
Pancreatic progenitor 1 gene and its uses
Patent Number: 6911533PP1 is a protein marker of a type of tissue stem cells or progenitor cells. The PP1 protein is made of 221 amino acids and contains two cysteine-rich domains. PP1 is expressed in the ducts of the regenerating pancreas in regions where new islets are developing. In addition, PP1 is expressed in embryonic foregut, stomach and duodenum, but not in developing pancreas or mature pancreas, The PP1...
Inventors: Sarvetnick, Nora (San Diego, CA); Fox, Howard (San Diego, CA)
Assignee: The Scripps Research Institute (La Jolla, CA)
Date of First Priority Issue: Wednesday April 26th, 2000
Method of treating leukopenia with adenosine
Patent Number: 6911435Lack of leukocyte production, leukopenia, is a major morbidity and mortality factor in patients recieving high dose chemotherapy, as well as after bone marrow transplant. This patent is very useful since it teaches how to expand hematopoietic stem cell production of leukocytes through administration of adenosine, a compound that is already clinically used. The patent has two independent...
Inventors: Cohn, Ilan (Herzlia, IL); Fishman, Pnina (Herzlia, IL)
Assignee: Can-Fite Biopharma Ltd. (Petach Tikva, IL)
Date of First Priority Issue: Thursday July 10th, 1997
Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
Patent Number: 6911429Tissue injury is associated with increased concentrations of hyaluronan (hyaluronic acid, HA). HA modifies cell behavior, including causing fibrosis and inflammation through interaction with cell-associated receptors such as receptor for HA-mediated motility (RHAMM, CD168). The present invention provides compounds that bind to HA and thereby inhibit the binding of HA to RHAMM Thus this...
Inventors: Cruz, Tony (Toronto, CA); Pastrak, Aleksandra (Tornto, CA); Turley, Eva A. (Toronto, CA)
Assignee: Transition Therapeutics Inc. (Toronto, CA)
Date of First Priority Issue: Thursday April 1st, 1999
Allogeneic and xenogeneic transplantation
Patent Number: 6911220This patent is for a very interesting idea. The induction of tolerance by ablating recipient T cells and recipient thymus, introducting a donor fetal or neonatal thymus, and allowing recipient T cells to mature with the donor thymus. This is based on the whole concept of inducing negative selection so that the recipient T cells will not kill the donor graft...but instead recognize it as...
Inventor: Sachs, David H. (Newton, MA)
Assignee: The General Hospital Corporation (Boston, MA)
Date of First Priority Issue: Wednesday February 19th, 1992
Method of producing undifferentiated hemopoietic stem cells using a stationary phase plug-flow bioreactor
Patent Number: 6911201One of the limiting factors to clinical use of autologous hematopoietic stem cells, as well as cord blood cells, is the limited ways of expanding them. This patent addresses this issue by providing a novel system for such expansion that appears to be more "in vivo-like". Essentially, the patent has 2 independent claims covering: A method of expanding undifferentiated hemopoietic stem...
Inventors: Merchav, Shoshana (Haifa, IL); Meretzki, Shai (Nesher, IL)
Assignee: Technion Research & Development Foundation Ltd. (Haifa, IL)
Date of First Priority Issue: Thursday February 4th, 1999
Methuselah gene, compositions and methods of use
Patent Number: 6906181The Methuselah gene mutation is associated with enhanced longevity. Specifically, flies with methuselah (mth) have approximately a 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator (Lin YJ, et al. Extended life-span and stress resistance in the Drosophila mutant...
Inventors: Lin, Yi-Jyun (Arcadia, CA); Benzer, Seymour (San Marino, CA)
Assignee: California Institute of Technology (Pasadena, CA)
Date of First Priority Issue: Tuesday July 7th, 1998
Mammalian common lymphoid progenitor cell
Patent Number: 6908763The stem cell identified in this patent is a type of progenitor cell that can differentiate only along the lymphoid, but not myeloid lineage. These cells are useful for situations in which lymphopoiesis is desired, for example, after lymphodepletion of a cancer patient in protocols used for homeostatic induced antitumor immunity. The patent essentially covers a cell type that expresses...
Inventors: Akashi, Koichi (Chestnut Hill, MA); Kondo, Motonari (Redwood City, CA); Weissman, Irving L. (Redwood City, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University (Palo Alto, CA)
Date of First Priority Issue: Friday August 22nd, 1997
Compounds and methods for regulating cell differentiation
Patent Number: 6908732The use of various bile extracts for treatment of cancer is known in the art. The Canadian company Lorus Therapeutics developed a drug called Virulizing from cow bile extracts. This patent teaches the use of bilins for treatment of cancer through induction of cellular differentiation. The advantage of inducing cancer cell differentiation is the possibility of a less toxic approach in contrast...
Inventor: Falchuk, Kenneth H. (Newton, MA)
Assignee: President & Fellows of Harvard College (Cambridge, MA)
Date of First Priority Issue: Friday October 13th, 2000
Generation of viable cell active biomaterial patterns by laser transfer
Patent Number: 6905738This patent was included the 3d culture/scaffold section since it doesnt really seem to fit anywhere else. Essentially the patent teachs how to write on cells (including stem cells) using laser light. The patent has 1 independent claim, which is: A method for laser deposition comprising the steps of; providing one or more sources of laser energy that produce laser energy; providing...
Inventors: Ringeisen, Bradley R. (Alexandria, VA); Chrisey, Douglas B. (Bowie, MD); Pique, Alberto (Crofton, MD); McGill, R. Andrew (Lorton, VA)
Assignee: The United States of America as represented by the Secretary of the Navy (Washington, DC)
Date of First Priority Issue: Tuesday May 25th, 1999