Patents
Human ovarian mesothelial cells and methods of isolation and uses thereof
Patent Number: 6927061This paper teaches the isolation of bi-potent overian stem cells that can differentiate either into overian epithelium, or granulosa cells. The cell type claimed can be used for many purposes, including: a) generation of antibodies; b) cell therapy; c) bioassays; d) drug screening. The patent has two independent claims that cover: A method of isolating a substantially pure population of...
Inventors: Li, Rong-hao (Millbrae, CA); Bald, Laura (Los Altos, CA); Mather, Jennie Powell (Millbrae, CA)
Assignee: Raven Biotechnologies, Inc. (South San Francisco, CA)
Date of First Priority Issue: Monday April 10th, 2000
Methods to prepare and use epidermal stem cells
Patent Number: 6927060This is a method of isolating stem cells by dye exclusion and applying the principle to epidermal stem cells. It is well known in the art that stem cells are the property to exclude various dyes. This is what causes the existance of the "side population cells" which were known since 1996 (Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC. Isolation and functional properties of murine...
Inventors: Bickenbach, Jackie R. (Iowa City, IA); Dunnwald, Martine (Iowa City, IA)
Assignee: University of Iowa Research Foundation (Iowa City, IA)
Date of First Priority Issue: Tuesday March 28th, 2000
Human embryonic stem cells derived from frozen-thawed embryo
Patent Number: 6921632This patent covers a new way of extracting embryonic stem cells from human blastocyst embryos that have been frozed. The patent is assigned to a Korean Infertility Clinic. It appears that some of the ES cell lines made by this clinic are on the NIH list. The patent has 2 independent claims: A process for making undifferentiated human embryonic stem cells, comprising the steps of: (a...
Inventors: Lim, Jin-Ho (Seoul, KR); Park, Se-Pill (Seoul, KR); Kim, Eun-Young (Seoul, KR)
Assignee: Maria Biotech Co., Ltd. (Seoul, KR)
Date of First Priority Issue: Sunday April 30th, 2000
Method of genetically modifying very primitive quiescent human hematopoietic stem cells
Patent Number: 6919209Gene therapy is limited by ability to transfect quiescent cells. Since the very primitive hematopoietic stem cells reside in a quiescent state, it is difficult to transfect them. This patent demonstrates transfection of early hematopoietic stem cells using an adeno-associated vector. The patent has one independent claim that covers: A method for stably transferring DNA into multi-potential...
Inventors: Chatterjee, Saswati (Sierra Madre, CA); Wong, Jr., Kamehameha K. (Sierra Madre, CA); Wong, Christie (Pasadena, CA); Fisher-Adams, Grace (La Canada, CA)
Assignee: City of Hope (Duarte, CA)
Date of First Priority Issue: Friday December 4th, 1998
Medium containing flt3 ligand for culturing hematophoietic cells
Patent Number: 6919206This patent covers the use of flt-3 ligand for expanding hematopoietic stem cells in vitro. The importance of expansion techniques is seen in that numerous groups have tried and are still trying to identify ways of generating large populations of autologous stem cells. The patent is pretty straight-forward and has 2 independent claims: A hematopoietic cell expansion medium, comprising a...
Inventors: Lyman, Stewart D. (Seattle, WA); Beckmann, M. Patricia (Poulsbo, WA)
Assignee: Immunex Corporation (Thousand Oaks, CA)
Date of First Priority Issue: Monday March 7th, 1994
Isolating cells expressing secreted proteins
Patent Number: 6919183This patent teaches ways of extracting cells from a population based on expression of markers that were either introduced or naturally expressed in the cell. The patent may be useful for pulling out differentiated cells from stem cell heterogenous populations. A method of detecting and/or isolating a eukaryotic cell that produces a secreted protein of interest (POI), comprising: (a...
Inventors: Fandl, James P. (LaGrangeville, NY); Stahl, Neil (Carmel, NY); Chen, Gang (Yorktown Heights, NY); Yancopoulos, George D. (Yorktown Heights, NY)
Assignee: Regeneron Pharmaceuticals, Inc. (Tarrytown, NY)
Date of First Priority Issue: Tuesday January 16th, 2001
System for administering a combination of therapies to a body lumen
Patent Number: 6918869This patent teaches ways of administering agents into the lumen of a body, agents including stem cell therapy. The patent seems to cover methods of administering agents in a manner that does not induce restenosis. The patent has 3 independent claims, which are: A system for delivering a biologically active material to a surface of a body lumen exposed to a radioactive source comprising: (a...
Inventors: Shaw, William J. (Cambridge, MA); Barry, James (Marlborough, MA); Goll, Paul J. (Woodinville, WA); Palasis, Maria (Wellesley, MA)
Assignee: SciMed Life Systems (Maple Grove, MN)
Date of First Priority Issue: Monday December 2nd, 2002
Method for vocal cord reconstruction
Patent Number: 6918396This invention is useful for repairing injuries to head and neck tissue through use of vertebrate-derived submucosa or basement membrane matrices as a graft for the regeneration and repair of said head and neck soft tissues. Specifically, it is known that a) The naturally-occurring extracellular matrix (ECM) of the small intestinal submucosa, as well as other vertebrate sources of...
Inventors: Badylak, Stephen F. (West Lafayette, IN); Spievack, Alan R. (Cambridge, MA)
Assignee: Purdue Research Foundation (West Lafayette, IN); Clarian Health Partners, Inc. (Indianapolis, IN)
Date of First Priority Issue: Tuesday December 1st, 1998
Cultured skin and method of manufacturing the same
Patent Number: 6916655This patent is useful for generation of skin cells and skin-like cells from umbilical cords. Since cord blood is extracted from the cord and the cord is usually disposed of, this patent may be of particular importance. The only disadvantage of this patent is that its 1 issued claim seems to cover only a certain method of culturing the cells in a specific media. A method of culturing umbilical...
Inventors: Yasumoto, Shigeru (Kanazawa-ken, JP); Takeuchi, Masakatsu (Osaka, JP)
Assignee: Nipro Corporation (Osaka, JP)
Date of First Priority Issue: Thursday November 22nd, 2001
Universal donor cells
Patent Number: 6916654This patent covers the modification of cells to make them "universal donors" and thus not be rejected by the immune system. Not only is it next to impossible to completely inhibit expression of all immunogenic MHC molecules, but even if this is accomplished, the influence of the NK cells which kill tissue not expressing MHC must also be overcome. This patent is an interesting idea but of very...
Inventors: Sims, Peter J. (Mequon, WI); Bothwell, Alfred L. M. (Guilford, CT); Elliot, Eileen A. (New Haven, CT); Flavell, Richard A. (Killingworth, CT); Madri, Joseph (North Branford, CT); Rollins, Scott (Monroe, CT); Bell, Leonard (Woodbridge, CT); Squinto, Stephe
Assignee: Oklahoma Medical Research Foundation (Oklahoma City, OK); Yale University (New Haven, CT)
Date of First Priority Issue: Monday June 29th, 1992