Patents
Methods to stimulate insulin production by pancreatic beta-cells
Patent Number: 6903073Hedgehog proteins are involved in development and other biological functions through activation of their receptor called "patched". Hedgehog signalling is inhibited by cyclopamine. Since the authors of the patent originally found that inhibiting hedgehog signalling reduces insulin production, and transfection with hedgehog increases insulin production, (Thomas MK, Rastalsky N, Lee JH, Habener...
Inventors: Habener, Joel F. (Newton Centre, MA); Thomas, Melissa K. (Boston, MA)
Assignee: The General Hospital Corporation (Boston, MA)
Date of First Priority Issue: Friday December 10th, 1999
Compounds and methods for regulating cell differentiation
Patent Number: 6902881This patent teaches the use of a bilin for treating cancer through induction of differentiation. It is a very promising idea since differentiation therapy is relatively non-toxic. The question is what concentrations of these bilins are needed to actually see an in vivo effect. The 2 independent claims of the patent are: A method for promoting cell differentiation, comprising treating a...
Inventor: Falchuk, Kenneth H. (Newton, MA)
Assignee: President and Fellows of Harvard College (Cambridge, MA)
Date of First Priority Issue: Friday October 13th, 2000
Inhibitors of proteasomal activity for stimulating bone growth
Patent Number: 6902721This patent teaches that proteosome inhibitors stimulate the growth of bone, in part through inhibition of the inflammatory-associated transcription factor NF-kB. It is unclear if the stimulation of bone growth works via activation of stem cells, or other mechanisms. The patent also discloses use for stimulation of hair growth, but that is not in the claims. The one independent claim is: A...
Inventors: Mundy, Gregory R. (San Antonio, TX); Garrett, I. Ross (San Antonio, TX); Rossini, Jorge G. (San Antonio, TX)
Assignee: OsteoScreen, Inc. (San Antonio, TX)
Date of First Priority Issue: Friday July 10th, 1998
Lineage restricted glial precursors from the central nervous system
Patent Number: 6900054Glial cells performed numerous functions in the nervous system including providing support, nutrition, and form myelin for neurons. They represent 90% of the cells in the central nervous system. The ability to generate glial cells ex vivo is critical not only for the potential of administering such cells to damaged areas, but also for using these cells are vectors to carry genes in order to...
Inventors: Rao, Mahendra S. (Salt Lake City, UT); Noble, Mark (Brighton, NY); Mayer-Proschel, Margot (Pittsford, NY)
Assignee: University of Utah Research Foundation (Salt Lake City, UT)
Date of First Priority Issue: Saturday November 29th, 1997
Human hematopoietic growth regulatory gene and uses
Patent Number: 6900017HIWI is the human homologue of PIWI a gene found in fruitfly embryonic germline stem cells. HIWI is found in CD34 hematopoietic cells and appears to act as a negative regulator in that its transfection causes apoptosis in hematopoietic cell lines (Sharma AK, et al. Human CD34 stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi. Blood. 2001 Jan 15;97(2):426-34...
Inventors: Sharma, Arun (Oak Park, IL); Hoffman, Ronald (Chicago, IL)
Assignee: The Board of Trustees of the University of Illinois (Urbana, IL)
Date of First Priority Issue: Thursday January 10th, 2002
Methods and compositions for culturing a biological tooth
Patent Number: 6899915Inventors: Yelick, Pamela C. (Concord, MA); Bartlett, John D. (Acton, MA); Vacanti, Joseph P. (Winchester, MA); Olsen, Bjorn R. (Milton, MA); Stashenko, Phillip (Medfield, MA)
Assignee: President and Fellows of Harvard College (Cambridge, MA); General Hospital Corporation (Boston, MA); Forsyth Dental Infirmary for Children, Inc. (Boston, MA)
Date of First Priority Issue: Wednesday November 29th, 2000
Transdifferentiation of glial cells
Patent Number: 6897061This patent teaches how to make astrocytes into neurons and/or oligodendrocytes. The ability to perform this in large scale would allow for cell replacement therapy for a variety of neural degenerative conditions. The independent claims are: An in vitro method to produce a population that includes neurons and/or oligodendrocytes, the method comprising: (a) obtaining and/or isolating a...
Inventor: Salin-Nordstrom, Tuija Helina (Santa Monica, CA)
Assignee: Spinal Cord Society (Fergus Falls, MN)
Date of First Priority Issue: Friday June 16th, 2000
Composition comprising multipotent neural stem cells for generation of hematopoietic cells
Patent Number: 6897060Inventors: Bjornson, Christopher R. (Seattle, WA); Rietze, Rod L. (Brunswick, AU); Reynolds, Brent A. (Saltspring, CA); Vescovi, Angelo L. (Milan, IT)
Assignee: NeuroSpheres Holdings, Ltd. (Calgary, CA)
Date of First Priority Issue: Monday September 29th, 1997
Human ovarian mesothelial cells and methods of isolation and uses thereof
Patent Number: 6893871This is a patent covering an ovarian stem cell that can become either overian epithelial tissue, as well as granulosa tissue. The three independent claims are: A method of providing a source of immunogen to a heterologous recipient, comprising administering a plurality of ovarian mesothelial cells in an amount effective to induce an immune response in said recipient, wherein said ovarian...
Inventors: Li, Rong-hao (Millbrae, CA); Bald, Laura (Los Altos, CA); Mather, Jennie Powell (Millbrae, CA)
Assignee: Raven Biotechnologies, Inc. (South San Francisco, CA)
Date of First Priority Issue: Tuesday April 10th, 2001
Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair
Patent Number: 6890897This patent teaches the novel use of melanoma inhibitory factor to induce stem cell differentiation into bone and cartilage. It may be used for in vitro generation of stem cells or for acceleration of in vivo healing. The independent claims of the patent are: A method for inducing chondro-/ostrogenic lineage and promoting of cartilage or bone formation in a person comprising administering a...
Inventors: Dony, Carola (Munchen, DE); Proetzel, Gabriele (Schwanfeld, DE); Leser-Reiff, Ulrike (Penzberg, DE)
Assignee: Scil Technology GmbH (Martinsried, DE)
Date of First Priority Issue: Thursday January 28th, 1999