Patents
Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue
Patent Number: 6878371This is a very important patent for the clinical trials ongoing right now that are administering bone marrow autolous stem cells into the heart of patients in order to stimulate angiogenesis. This paten is definately worthy of detailed reading and understanding in light of existing clinical research in this area.
Inventors: Ueno, Takafumi (Decatur, GA); Murohara, Toyoaki (Fukuoka, JP); Robinson, Keith Allen (Norcross, GA); Chronos, Nicolas A. F. (Atlanta, GA); Baldwin, Sam (Newton, MA); Palasis, Maria (Wellesley, MA)
Assignee: Boston Scientific Scimed, Inc. (Maple Grove, MN)
Date of First Priority Issue: Wednesday July 26th, 2000
Mixed chimerism and tolerance
Patent Number: 6877514This patent teaches how to induce allogeneic tolerance to transplanted grafts through making the recipient a chimera in terms of blood composition. In other words, donor hematopoietic stem cells are administered in order to make the recipient have both donor blood cells circulating, as well as some left over recipient cells. This system has been shown effective in several animal models.
Inventor: Sykes, Megan (Charlestown, MA)
Assignee: The General Hospital Corporation (Boston, MA)
Date of First Priority Issue: Thursday May 9th, 1996
Propagation and/or derivation of embryonic stem cells
Patent Number: 6875608This patent discloses compounds that can be added to a culture of embryonic stem cells so as to selectively kill non-embryonic stem cells.
Inventors: Smith, Austin Gerard (Edinburgh, GB); Burdon, Thomas Grant (Edinburgh, GB)
Assignee: University of Edinburgh (Edinburgh, GB)
Date of First Priority Issue: Friday September 11th, 1998
Embryonic stem cells
Patent Number: 6875607Despite its appealing title, the claims of this patent appear only to cover the alteration of differentiation of embryonic stem cells, in part through providing the use of feeder cell layers.
Inventors: Reubinoff, Benjamin Eithan (Elsternwick, AU); Pera, Martin Frederick (Prahran, AU); Fong, Chui-Yee (Singapore, SG); Trounson, Alan Osborne (Asburton, AU); Bongso, Ariffeen (Singapore, SG)
Assignee: ES Cell International Pte Ltd (Singapore, SG)
Date of First Priority Issue: Monday November 9th, 1998
Composition for delivery of hematopoietic growth factor
Patent Number: 6875441This patent teaches ways of formulating G-CSF so as to have better pharmacological properties. Specifically the patent is trying to address the problem of: "...administration of hematopoietic growth factors such as G-CSF, GM-CSF, SCF and Flt3-L, requires multiple daily injections. This, in turn leads to another common disadvantage of current injectable therapies such as these, that being the...
Inventors: Rosenthal, Gary J. (Louisville, CO); Etter, Jeffrey B. (Boulder, CO)
Assignee: RxKinetix, Inc. (Louisville, CO)
Date of First Priority Issue: Friday May 26th, 2000
Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
Patent Number: 6875430Xenotransplantation is limited primarily by antibody mediated rejection. Accordingly while this patent covers the use of mesenchymal stem cells for preventing xenograft rejection, the actual applicability of this patent seems unlikely since mesenchymal stem cells do not strongly protect against antibody mediated immune rejection in xenotransplantation.
Inventors: McIntosh, Kevin R. (Ellicott City, MD); Mosca, Joseph D. (Ellicott City, MD); Klyushnenkova, Elena (Baltimore, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Wednesday March 18th, 1998
Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells
Patent Number: 6872819This patent describes biomaterials that can be administered in an area of tissue injury to allow for stem cells to expand locally and produce new functional tissue. The biomaterials covered appear to be hyaluronic acid based.
Inventors: Pavesio, Alessandra (Padua, IT); Dona' , Massimo (Due Carrare, IT); Callegaro, Lanfranco (Thiene, IT)
Assignee: Fidia Advanced Biopolymers S.r.l. (Brindisi, IT)
Date of First Priority Issue: Wednesday May 27th, 1998
Hepp, a novel gene with a role in hematopoietic and neural development
Patent Number: 6872812HEPP is a gene that appears to be found in certain stem cell populations involved in differentiation, although its function remains unclear. This patent is a composition of matter patent on the gene. If there are some interesting properties found with this protein, it may be a really good patent to license since not too much work has been performed on it.
Inventors: Jurecic, Roland (Key Biscayne, FL); Nachtman, Ronald G. (Miami, FL)
Assignee: University of Miami (Miami, FL)
Date of First Priority Issue: Friday February 16th, 2001
In vitro production of haploid germ cells
Patent Number: 6872569This patent teaches how to generate sperm in vitro through the use of sertoli cells and undifferentiated diploid germ cells. It is useful not only for infertility applications, but also for various veterinary purposes.
Inventors: Lee, Dong Ryul (Seoul, KR); Kaproth, Michael T. (Ithaca, NY); Parks, John E. (Ithaca, NY)
Assignee: Cornell Research Foundation, Inc. (Ithaca, NY)
Date of First Priority Issue: Friday May 18th, 2001
Liver stem cell
Patent Number: 6872389This patent covers a liver stem cell that is isolated based on expression of the marker OV6. These cells could be used for a variety of therapeutic purposes including hepatitis. Liver cell therapy can be performed by administration of single cell suspensions, additionally attractive with this patent is that liver cells are generally more tolerogenic and less likely to rejection than other...
Inventor: Faris, Ronald A. (Providence, RI)
Assignee: Rhode Island Hospital (Providence, RI)
Date of First Priority Issue: Friday July 10th, 1998