Patents
Methods and compositions for neural progenitor cells
Patent Number: 6890724This patent teaches how to extract neural precursor cells by expression of a protein called RET. RET is orphan receptor tyrosine kinase essential for enteric neurogenesis The patent has two independent claims. That are: A method for the enrichment of neural progenitor cells comprising RET protein, said method comprising: a) combining a mixed population of cells comprising neural-crest...
Inventors: Anderson, David J. (Altadena, CA); Lo, Li-Ching (Arcadia, CA)
Assignee: California Institute of Technology (Pasadena, CA)
Date of First Priority Issue: Friday September 6th, 1996
Method of in vitro differentiation of transplantable neural precursor cells from primate embryonic stem cells
Patent Number: 6887706This patent is from the same group that originally patented embryonic stem cells of human. In the current patent there is one independent claim that covers the differentiation of human embryonic stem cells into neural progenitor cells. The method claims involves culturing so that embryoid bodies are formed from the embryonic stem cells through incubation with FGF-2, as well as standard culture...
Inventors: Zhang, Su-Chun (Middleton, WI); Thomson, James A. (Madison, WI); Duncan, Ian David (Madison, WI)
Assignee: Wisconsin Alumni Research Foundation (Madison, WI)
Date of First Priority Issue: Wednesday October 3rd, 2001
Methods of controlling proliferation and differentiation of stem and progenitor cells
Patent Number: 6887704This patent teaches the ex vivo expansion of stem cells of the hematopoietic lineage through culture in conditions having reduced copper content. The patent is useful for expanding CD34 stem cells for treatment of a variety of diseases and conditions in which CD34 numbers and/or activity may be beneficial. The fact that copper chelation is practiced as alternative medicine may have something...
Inventors: Peled, Tony (Mevaseret Zion, IL); Fibach, Eitan (Mevaseret Zion, IL); Treves, Avi (Mevaseret Zion, IL)
Assignee: Gamida Cell Ltd. (Jerusalem, IL)
Date of First Priority Issue: Tuesday February 17th, 1998
Method for fabricating cell-containing implants
Patent Number: 6886568This patent teaches the generation of cells with implantable biodegradable material through culture in vitro with materials of various compositions. The patent may be used for generation of artificial tissue, or for creating clusters of cells that may be implantable for treatment of disease. The patent is particularly aimed at inducing generation of chondrocytes ex vivo or in vitro for...
Inventors: Frondoza, Carmelita G. (Woodstock, MD); Fink, David J. (Baltimore, MD); Hungerford, David S. (Cockeysville, MD); Shikani, Alan H. (Ruxton, MD)
Assignee: The Johns Hopkins University (Baltimore, MD); Chrondros, Inc. (Baltimore, MD)
Date of First Priority Issue: Thursday April 9th, 1998
Inhibitors of proteasomal activity for stimulating hair growth
Patent Number: 6884769Proteosomes are becoming important biological targets in drug discovery. For example pathways associated with numerous diseases, such as NF-kB are dependent on proteosomal activation. In the case of NF-kB the proteosomal degradation of phosphorylated IKB is what allows translocation of NF-kB into the nucleus. In this patent inhibition of the chymotrypsin-like activity proteasomes is claimed...
Inventors: Mundy, Gregory R. (San Antonio, TX); Garrett, I. Ross (San Antonio, TX); Rossini, Jorge Gianny (San Antonio, TX) )
Assignee: OsteoScreen, Inc. (San Antonio, TX
Date of First Priority Issue: Friday July 10th, 1998
Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
Patent Number: 6884428This patent covers scaffolds that may be administered in vivo so that stem cells and progenitor cells attach to the scaffold and form functional tissue. Alternatively, the patent teaches that such scaffolds may be used in vitro so that cells form a functional tissue in vitro, which is then administered in vivo. Specific tissues that are described for use in the context of the current scaffold...
Inventors: Binette, Francois (Weymouth, MA); Bowman, Steven M. (Sherborn, MA); Bruker, Izi (Wayland, MA); Hwang, Julia (Wayland, MA); Melican, Mora Carolynne (Bridgewater, NJ); Rezania, Alireza (Hillsborough, NJ)
Assignee: DePuy Mitek, Inc. (Norwood, MA)
Date of First Priority Issue: Thursday December 21st, 2000
Filamentary means for introducing agents into tissue of a living host
Patent Number: 6884427This patent teaches a method of administering cells, including stem cells, through use of a filament-type object. The object has a solid core and an outside sheath that is porous and to which cells can be attached to before administration. The invention teaches that hair follicle cells, cells that have been encapsulated, and cells that have been genetically engineered can be administered...
Inventor: Barrows, Thomas H. (Austell, GA)
Assignee: Aderans Research Institute, Inc. (Beverly Hills, CA)
Date of First Priority Issue: Monday February 8th, 1999
Bioabsorbable breast implant
Patent Number: 6881226This patent covers a breast implant that eventually resorbs and is replaced by endogenous tissue. The patent has claims covering not only the use for cosmetic reasons, but also for administration of therapeutic agents.
Inventors: Corbitt, Jr., John D. (Palm Springs, FL); Leonetti, Lori A. (Delray Beach, FL)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday March 11th, 1998
Cultures of GFAP+ nestin+ cells that differentiate to neurons
Patent Number: 6878543Generation and expansion of neuronal cells is described in this patent through inducting proliferation of GFAP+, nestin+ stem cells of neuronal origin through treatment with EGF, amphiregulin, aFGF, bFGF, TGF.alpha. and then inducing differentiation through serum free culture. The cells generated by this means can be made into neurons or glial cells depending on culture conditions.
Inventors: Wahlberg, Lars (Asnaes, DK); Campbell, Kenneth (Cincinnati, OH); Skogh, Charlotta (Malmo, SE); Eriksson, Cecilia (Falsterbo, SE); Wictorin, Klas (Lund, SE)
Assignee: NsGene SA (Ballerup, DK)
Date of First Priority Issue: Monday October 25th, 1999
Isolation, selection and propagation of animal transgenic stem cells
Patent Number: 6878542This patent appears to be a really unique way of expanding stem cells. Essentially the patent teaches to connect a growth factor receptor to a promoter that is only expressed on stem cells, such as the promoter for Oct-4. This way stem cells will express the growth factor receptor. This way if you add the ligand for the receptor the stem cells will proliferate selectively. Theoretically, the...
Inventors: Smith, Austin Gerard (Edinburgh, GB); Mountford, Peter Scott (Elsdenwid, AU)
Assignee: The University of Edinburgh (GB)
Date of First Priority Issue: Thursday April 21st, 1994