Patents
Methods of creating constructs useful for introducing sequences into embryonic stem cells
Patent Number: 6942995This invention relates to the generation of knock-out animals Through genetically ablating a specific gene sequence in embryonic stem cells of an animal, it is possible to develop animals, called"knock-outs" which lack the specific sequences throughout all cells of the body. The patent has two independent claims directed towards unique gene-targeting constructs that through homologous...
Inventors: Klein, Robert D. (Palo Alto, CA); Brennan, Thomas J. (South San Francisco, CA)
Assignee: Deltagen, Inc. (San Carlos, CA)
Date of First Priority Issue: Monday November 17th, 1997
Bioartificial filtration device for filtering blood to mimic kidney function
Patent Number: 6942879This patent is for a bioartificial kidney suitable for a variety of uses, including in patients with renal failure. The patent has one independent claim covering a filtration device which contains a layer of non-immortalized renal endothelial cells, non-immortalized renal epithelial cells, or a mixture thereof, and (ii) pericytes, vascular smooth muscle cells. This approach is currently in Phase...
Inventor: Humes, H. David (Ann Arbor, MI)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Monday September 30th, 1996
Hematopoietic growth factor inducible neurokinin-1 gene
Patent Number: 6939955This is a composition of matter patent for a receptor that seems to be involved in hematopoietic stem cell expansion. The invention discloses a novel gene, HGFIN, which encodes a protein receptor that is involved in the regulation of hematopoietic proliferation and differentiation, and may act as a negative regulator of the Id2 protein. The invention has 2 independent claims. The first covers...
Inventor: Rameshwar, Pranela (Maplewood, NJ)
Assignee: University of Medicine and Dentistry of New Jersey (New Brunswick, NJ)
Date of First Priority Issue: Friday October 20th, 2000
Human mesenchymal progenitor cell
Patent Number: 6936281This is a composition of matter patent for mesenchymal stem cell progenitors. The first three independent claims of this patent are restricted to generation of these cells from a Dexter type culture system (a specific type of long term culture in which adherent cells are allowed to form a layer and the hematopoietic cells rely on their support). The forth independent claim is not restricted...
Inventor: Seshi, Beerelli (Tampa, FL)
Assignee: University of South Florida (Tampa, FL)
Date of First Priority Issue: Wednesday March 21st, 2001
Method of inducing fetal hemoglobin synthesis
Patent Number: 6936254This patent covers induction of fetal hemoglobin gene expression by treatment of cells with specific polypeptides. The utility of inducing fetal hemoglobin is for diseases in which adult hemoglobin is defective in carrying oxygen. This invention is useful for the treatment of diseases like sickle cell anemia. The patent has 2 independent claims that essentially cover: a) Induction of adult to...
Inventors: Baker, Kevin P. (Darnestown, MD); Botstein, David (Belmont, CA); Eaton, Dan L. (San Rafael, CA); Ferrara, Napoleone (San Francisco, CA); Filvaroff, Ellen (San Francisco, CA); Gerritsen, Mary E. (San Mateo, CA); Goddard, Audrey (San Francisco, CA); Godowsk
Assignee: Genentech, Inc. (South San Francisco, CA)
Date of First Priority Issue: Wednesday December 3rd, 1997
Therapeutic delivery compositions and methods of use thereof
Patent Number: 6933286The introduction of nucleic acids into cells is a difficult task that has significantly hampered gene therapy. This patent discloses a novel method of getting nucleic acids into cells. The patent has 2 independent claims. The first covers a composition of nucleic acid sequences or one or more triplex DNA compounds, and a nonionic block copolymer. The second covers the method of introducing a...
Inventors: Emanuele, R. Martin (Alpharetta, GA); Newman, Mark (Carlsbad, CA); Kousoulas, Konstantin G. (Baton Rouge, LA); Allaudeen, Hameedsulthan S. (Durham, NC)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday March 19th, 1991
Molecules that home to various selected organs or tissues
Patent Number: 6933281This patent teaches the use of peptides that have the ability to home to specific tissues. Such homing peptides may be used to deliver drugs or therapeutic agents, as well as (conceptually) to administer activators of stem cells. The patent has 4 independent claims: - A lymph node homing peptide which is PTCAYGWCA (SEQ ID NO: 336). - A conjugate, comprising the peptide which is...
Inventors: Ruoslahti, Erkki (Rancho Santa Fe, CA); Pasqualini, Renata (Solana Beach, CA)
Assignee: The Burnham Institute (San Diego, CA)
Date of First Priority Issue: Friday March 13th, 1998
Relationship of ABC transport proteins with hematopoietic stem cells and methods of use thereof
Patent Number: 6933150This patent seems to cover methods of purifying and expanding hematopoietic stem cells by transfecting said stem cells with a drug efflux pump. It is not clear if the patent calls for administration of a cytotoxic agent to selectively kill non-stem cells, or if it is inherently the property of the efflux pumps to increase stem cell viability. The patent has 2 independent claims: A method of...
Inventors: Sorrentino, Brian (Memphis, TN); Bunting, Kevin (Columbus, MD); Schuetz, John (Memphis, TN); Nakauchi, Hiromitsu (Kukizaki-machi, JP)
Assignee: St. Jude Children's Research Hospital (Memphis, TN)
Date of First Priority Issue: Thursday May 28th, 1998
Lineage specific cells and progenitor cells
Patent Number: 6929948This patent teaches ways of extracting cells with a neural phenotype from a population of stem cells that are differentiated along the neural lineage through selecting cells that express a marker under control of a promoter which is active only in neural cells. Specifically, the patent claims the use the Sox gene promoter. One way to use this patent would be to insert GFP under control of Sox...
Inventors: Smith, Austin G. (Edinburgh, GB); Li, Meng (Edinburgh, GB)
Assignee: The University Court of the University of Edinburgh (GB)
Date of First Priority Issue: Wednesday April 14th, 1999
Hypoxia-mediated neurogenesis assay
Patent Number: 6924142This patent teaches the induction of differentiation of neural stem cells, the use of hypoxia for enhancing function, and the subsequent use of the cells obtained for drug screening. The patent has one independent claim that covers: A method for screening the effects of drugs or other agents on neuronal cells, comprising: a) preparing a cell culture comprising a cell population enriched in...
Inventors: Weiss, Samuel (Calgary, CA); Sorokan, S. Todd (Victoria, CA)
Assignee: Neuro Spheres Holdings Ltd. (Calgary, CA)
Date of First Priority Issue: Friday October 24th, 1997