Patents
Agents for preventing and treating thrombocytopenia
Patent Number: 6956022This patent teaches the use of an existing pharmaceutical, parathyroid hormone (or agonists of the parathyroid hormone receptor) for stimulation of platelet production. The patent has one issued claim which covers essentially what was just mentioned. This is an interesting patent because in a publication it states that "Between 1958 and the late 1970s it was learned that PTH (the parathyroid...
Inventors: Tamura, Masahiko (Shizuoka-ken, JP); Oda, Yasuhiro (Nagano-ken, JP)
Assignee: Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP)
Date of First Priority Issue: Tuesday January 2nd, 1996
Targeting pharmaceutical agents to injured tissues
Patent Number: 6955898This patent teaches was of targeting damaged tissue with genes that stimulate angiogenesis. Conceptually the technology could be modified to introduce agents which actually stimulate stem cell proliferation at the site of injury. The patent has one issued claim that covers a fusion polypeptide, with one end having a collagen binding domain which binds exposed vascular collagen (ie during...
Inventors: Hall, Frederick L. (Glendale, CA); Gordon, Erlinda M. (Glendale, CA); Starnes, Vaughn A. (Pasadena, CA); Anderson, W. French (San Marino, CA)
Assignee: University of Southern California (Los Angeles, CA)
Date of First Priority Issue: Friday July 31st, 1998
Modulation of cell fates and activities by diketo phthalazines
Patent Number: 6953799This patent teaches ways of modulating "stress" in cells through administration of "therapeutically effective amount of a phthalazine dione" in its one independent claim. The Assignee company, Bach Pharma, Inc is currently practicing the patent in the form of a registered drug (in Russia), Galavit® whose chemically active substance is Monosodium 5-Amino...
Inventors: Henry, Mark O. (North Andover, MA); Lynn, William S. (Hillsborough, NC)
Assignee: Bach Pharma, Inc. (North Andover, MA)
Date of First Priority Issue: Wednesday October 30th, 2002
Methods and compositions for the diagnosis and treatment of hematological disorders using 2777
Patent Number: 6953778This patent is a demonstration of creative patent writing, with positive results of claim issuance. Essentially, the inventors found a novel gene called 2777 which is significantly expressed in erythroid cells both in vitro and in vivo. 2777 is also expressed in erythroid progenitor (BFU-E) cells and Glycophorin A positive-lo (GPA-lo) cells in vivo. Since 2777 appears at a structural level to...
Inventor: Carroll, Joseph M. (Cambridge, MA)
Assignee: Millennium Pharmaceuticals, Inc. (Cambridge, MA)
Date of First Priority Issue: Wednesday October 31st, 2001
Instrument for regenerating living organism tissue or organ
Patent Number: 6953482Essentially the invention is a scaffold with a tube-like feature in which cells may be grown outside of the body to form an organ or tissue, and then will be used for implantation into the host. The tube-like features of the scaffold allow for growth of neurons, blood vessels, trachea, and other bodily parts. The patent has 2 independent claims. The first covers general features of the scaffold...
Inventors: Doi, Nobutoshi (Osaka, JP); Matsuda, Kazuhisa (Osaka, JP); Hata, Ken-ichiro (Kariya, JP); Sakai, Kensuke (Aichi, JP)
Assignee: Nipro Corporation (Osaka, JP); Ueda, Minoru (Nisshin, JP)
Date of First Priority Issue: Thursday April 26th, 2001
Hydrogels formed by non-covalent linkages
Patent Number: 6949590Hydrogels are very useful for adminstration of cells into localized tissues. One of the problems is that polymerization of hydrogels often uses catalysts, which add problems to medical implimentation due to adverse effects of catalysts. This invention teaches ways of making hydrogels so that they do not require catalysts. The invention has 3 independent claims. The first covers "...
Inventors: Ratner, Buddy D. (Seattle, WA); Nair, Prabha D. (Kerala, IN); Boeckl, Maximiliane Silvia (Seattle, WA); Leber, Elizabeth Reeves (Seattle, WA)
Assignee: University of Washington (Seattle, WA)
Date of First Priority Issue: Tuesday October 1st, 2002
Transdifferentiation of epidermal basal cells into neural progenitor cells, neuronal cells and/or glial cells
Patent Number: 6949380This invention is similar to patent 7041507, which was filed by the same inventors. The current invention teaches generation of neuronal-like cells through the transdifferentiation of epidermal basal cells. The invention has 3 independent claims covering, "An in vitro method of transdifferentiating an epidermal basal cell ", "A kit for transdifferentiating, in vitro, an epidermal...
Inventors: Levesque, Michel F. (Beverly Hills, CA); Neuman, Toomas (Santa Monica, CA)
Assignee: Cedars-Sinai Medical Center (Los Angeles, CA)
Date of First Priority Issue: Wednesday January 20th, 1999
Porous .beta.-tricalcium phosphate granules for regeneration of bone tissue
Patent Number: 6949251The invention is a composition of matter useful for treatment of bone defects and regeneration of bone. The composition is a porous ceramic material (beta.-tricalcium phosphate) of various pore sizes, porosity and granule size which is biocompatible with human tissue and supports the development of new bone throughout its structural form. The composition may be admixed with cells, cytokines...
Inventors: Dalal, Paresh S. (Shrewsbury, MA); Dimaano, Godofredo R. (Edison, NJ); Toth, Carol Ann (Sharon, MA); Kulkarni, Shailesh C. (Natick, MA)
Assignee: Stryker Corporation (Kalamazoo, MI)
Date of First Priority Issue: Saturday February 3rd, 2001
Progenitor cells, methods and uses related thereto
Patent Number: 6946293This patent teachs ways of expanding a certain type of pancreatic progenitor cell through the steps of first extracting pancreatic or ductal cells; second, treating the cells with a preparation comprising epidermal growth factor, a cAMP elevating agent, and a steroid or corticosteroid; and , third harvesting a non-adherent population. The first and second independent claims essentially cover the...
Inventors: Lu, Kuanghui (Brookline, MA); Pang, Kevin (Belmont, MA); Rubin, Lee (Wellesley, MA)
Assignee: ES Cell International Pte Ltd. (
Date of First Priority Issue: Saturday October 2nd, 1999
Human adult astrocytes, their preparation and uses thereof
Patent Number: 6943016This invention teaches how to obtain a population of astrocytes that is free of microglial cells from a fresh biopsy specimen. The invention has one independent claim covering the process of explanting a tissue that contains both astrocytes and microglial cells, culturing the cells in vitro under conditions that selectively promote adherence of the astrocytes to the culture vessel, and after about...
Inventors: Ridet, Jean-Luc (Lausanne, CH); Mallet, Jacques (Paris, FR)
Assignee: Aventis Pharma S.A. (Antony, FR)
Date of First Priority Issue: Saturday May 1st, 1999