Patents
Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
Patent Number: 6361976This patent teaches the use of various proteins that activate the IL-3 receptor in combination with other hematopoietic growth factors for the stimulation of hematopoietic stem cell proliferation.
Inventors: Bauer, S. Christopher (New Haven, MO); Abrams, Mark Allen (St. Louis, MO); Braford-Goldberg, Sarah Ruth (St. Louis, MO); Caparon, Maire Helena (Chesterfield, MO); Easton, Alan Michael (Maryland Heights, MO); Klein, Barbara Kure (St. Louis, MO); McKearn, J
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday November 24th, 1992
G-CSF receptor agonists
Patent Number: 6358505This patent provides various compositions of matters in the form of proteins that are useful for stimulating in an agonistic manner the receptor for granulocyte colony stimulating factor. This patent may be used for treatment of neutropenia as a way of getting around Amgen's G-CSF.
Inventors: Zurfluh, Linda (Kirkwood, MO); Klein, Barbara (St. Louis, MO); McWherter, Charles (Wildwood, MO); Feng, Yiping (St. Louis, MO); McKearn, John (Glencoe, MO); Braford-Goldberg, Sarah (St. Louis, MO)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday September 27th, 1995
Apparatus for extracting bone marrow
Patent Number: 6358252Usually bone marrow is extracted from the iliac crest of patients. In this patent a new device for extracting bone marrow is disclosed. The patent is useful for, intra alia, taking out bone marrow from the jaw bone of a subject that is undergoing dental surgery. If you thought root canals are painful, imagine this !
Inventor: Shapira, Ira L. (Highland Park, IL)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday July 1st, 1997
Uses for non-autologous mesenchymal stem cells
Patent Number: 6355239This patent covers the use of mesenchymal stem cells that are either allogeneic or xenogeneic for the purposes of regeneration and/or enhancing hematopoietic graft function. Since mesenchymal stem cells are immunosuppressive (at least locally), the use of immunosuppressants can be avoided. This patent would be interesting to use with islet grafts for the treatment of diabetes. I mean, some...
Inventors: Bruder, Scott P. (Waltham, MA); McIntosh, Kevin R. (Ellicott City, MD); Marshak, Daniel R. (Lutherville, MD); Mosca, Joseph D. (Ellicott City, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Friday March 13th, 1998
Methods for using the obese gene and its gene product to stimulate hematopoietic development
Patent Number: 6355237Leptin inhibits obesity. In this patent leptin is used in combination with other hematopoietic cytokines for the stimulation of hematopoietic stem cell function. Given the similarity between hematopoietic stem cells and neuronal stem cells, it would be interesting to assess the effects of leptin on neuronal stem cells.
Inventors: Snodgrass, H. Ralph (Powell, OH); Cioffi, Joseph (New Albany, OH); Zupancic, Thomas Joel (Worthington, OH); Shafer, Alan Wayne (Lancaster, OH)
Assignee: Progenitor, Inc. (Columbus, OH)
Date of First Priority Issue: Wednesday September 14th, 1994
Methods for implanting cells
Patent Number: 6352555This patent provides methods and devices for administration of cells, including stem cells, via various prosthetic devices.
Inventors: Dzau, Victor J. (Newton, MA); Pratt, Richard E. (Newton, MA); Mann, Michael J. (Newton, MA); Ehsan, Afshin (Boston, MA); Griese, Daniel P. (Boston, MA)
Assignee: The Brigham and Womens Hospital, Inc. (Boston, MA)
Date of First Priority Issue: Friday July 10th, 1998
Human growth hormone to stimulate hematopoiesis and immune reconstitution after hematopoietic stem cell transplantation in humans
Patent Number: 6348444This patent teaches the use of growth hormone to stimulate hematopoiesis. The fact that various hormones have hematopoietic activity suggests that it may be worthwhile to assess their activity on the growth of neural stem cells both in vitro, but also in vivo. I believe that there is evidence of hormones like testosterone increasing mental acuity in elderly patients...could this have something...
Inventor: Chappel, Scott C. (Milton, MA)
Assignee: Applied Research Systems ARS Holding N.V. (Curacao, NL)
Date of First Priority Issue: Thursday December 17th, 1998
G-CSF mimetics
Patent Number: 6346531This patent provides compositions of matter that are useful for stimulating the receptor for granulocyte colony stimulating factor. The fact that G-CSF was the first drug introduced that acted on the level of stem cells suggests that this is an important area for drug development. This patent may be useful not only for stimulation of neutrophil function, but also for increasing stem cell...
Inventors: Luengo, Juan I (Audubon, PA); Duffy, Kevin J (Norristown, PA)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Date of First Priority Issue: Saturday March 20th, 1999
Antibody composition for isolating human cells from human-murine chimeric hematopoietic cell suspensions
Patent Number: 6342344This patent provides kits for purifying out of a human-SCID mouse cells of human origin.
Inventors: Thomas, Terry E. (Vancouver, CA); Eaves, Connie J. (Vancouver, CA)
Assignee: StemCell Technologies Inc. (Vancouver, CA)
Date of First Priority Issue: Friday July 31st, 1998
Method of inhibiting the proliferation and causing the differentiation of cells with IGF-1 receptor antisense oligonucleotides
Patent Number: 6340674This patent teaches that inhibition of stem cell proliferation, and induction of differentiation may be achieved by inhibiting expression or function of the protein insulin like growth factor. This patent can also be used with more modern gene silencing techniques such as RNA interference.
Inventors: Baserga, Renato (Ardmore, PA); Sell, Christian (Philadelphia, PA); Rubin, Raphael (Penn Valley, PA)
Assignee: Thomas Jefferson University (Philadelphia, PA)
Date of First Priority Issue: Friday March 26th, 1993