Category: Hematopoietic (25)
Liquid tumors need blood
It is a widely accepted principle that angiogenesis is required for new tissue growth. This is particularly true in cancer where numerous therapeutic approaches have been used to target tumor angiogenesis, thus effectively choking the tumor. An interesting take on blocking angiogesis is that the endothelial cells, which are responsible for angiogenesis...
4-1BB inhibits myelopoiesis/dendritic cell generation
San Diego, CA -
We at StemCellPatents.com are very interested in trans-disciplinary findings (scientific disciplines are made by humans to make learning easier but the body functions by integration). One area where scientific disciplines are beginning to overlap more and more is between stem cells and the immune system. We all know that some types of stem cells, such as
Leukemia Vaccine
Houston, Texas -
Immune responses against tumors have been known for more than 100 years. For example Dr. Coley of Sloan Kettering observed that various bacterial infections induced regression of tumors in cancer patients. One particular type of cancer that has been demonstrated to respond to immunotherapy is chronic myeloid leukemia, a cancer of...
4.1BB Induces CD34 To Monocyte Differentiation
Singapore -
There are numerous examples of molecules associated with immune response having regulatory effects on stem cell function, and vice versa. Immune control of hematopoiesis can be seen in an issued US patent (# 7,332,158) describing that administration of activated peripheral blood mononuclear cells accelerates... Naples, Italy - The administration of bone marrow stem cells into ischemic muscles for treatment of critical limb ischemia is currently being performed in clinical trials, with results demonstrating stimulation of angiogenesis and functional improvement. Given that a substantial amount of the angiogenic response seems to... The desire to expand hematopoietic stem cells is not only a basic research accomplishment but would allow for widespread use of autologous stem cells, as well as expand the utilization of cord blood stem cells which are usually of concern due to the relatively low stem cell content. Various methods of expanding hematopoietic stem cells exist, for example,
Parathyroid hormone mobilization and limb ischemia
Expanding Hematopoietic Stem Cells by Removing Inhibitors
Turning on healthy stem cells, turning off leukemia
Sydney, Australia - The signals that control proliferation of hematopoietic stem cells are still relatively unknown. Not only is the study of the hematopoietic stem cell important because it is one of the most well characterized stem cell systems, but also it has some very strong practical implications in terms of treating disease. For example, hematopoietic toxicity is often the...
HSC Transplants...young thymus helps
Osaka, Japan - It is known that as humans grow up their thymus involutes, this is particularly noticable after puberty when various hormones cause en mass death and atrophy of thymic components. Now maybe its just me, but does it not seem odd that hematopoietic stem cell transplants which require the stem cell to differentiate...
Hematopoietic Stem Cells Patrolling The Body for Danger
Boston, MA - A potentially new role for stem cells has been described. In most cases, various stem cells such as mesenchymal stem cells as well as hematopoietic stem cells possess immune suppressive characteristics. In a recent publication (Massberg et al...
Give Me Air: Hematopoietic Stem Cells in Hypoxic Niches
Tokyo, Japan - It is generally known that early, non-proliferative stem cell reserves are sequestered in hypoxic niches. In a recent paper (Kubota et al. Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche. Biochem Biophys Res Commun. 2007 Nov 26) histological assessment was performed of cells in hypoxic niches of the bone marrow. The investigators analyzed...