Category: Hematopoietic (21)
Parathyroid hormone mobilization and limb ischemia
Naples, Italy -
The administration of bone marrow stem cells into ischemic muscles for treatment of critical limb ischemia is currently being performed in clinical trials, with results demonstrating stimulation of angiogenesis and functional improvement. Given that a substantial amount of the angiogenic response seems to... The desire to expand hematopoietic stem cells is not only a basic research accomplishment but would allow for widespread use of autologous stem cells, as well as expand the utilization of cord blood stem cells which are usually of concern due to the relatively low stem cell content. Various methods of expanding hematopoietic stem cells exist, for example,
Expanding Hematopoietic Stem Cells by Removing Inhibitors
Turning on healthy stem cells, turning off leukemia
Sydney, Australia - The signals that control proliferation of hematopoietic stem cells are still relatively unknown. Not only is the study of the hematopoietic stem cell important because it is one of the most well characterized stem cell systems, but also it has some very strong practical implications in terms of treating disease. For example, hematopoietic toxicity is often the...
HSC Transplants...young thymus helps
Osaka, Japan - It is known that as humans grow up their thymus involutes, this is particularly noticable after puberty when various hormones cause en mass death and atrophy of thymic components. Now maybe its just me, but does it not seem odd that hematopoietic stem cell transplants which require the stem cell to differentiate...
Hematopoietic Stem Cells Patrolling The Body for Danger
Boston, MA - A potentially new role for stem cells has been described. In most cases, various stem cells such as mesenchymal stem cells as well as hematopoietic stem cells possess immune suppressive characteristics. In a recent publication (Massberg et al...
Give Me Air: Hematopoietic Stem Cells in Hypoxic Niches
Tokyo, Japan - It is generally known that early, non-proliferative stem cell reserves are sequestered in hypoxic niches. In a recent paper (Kubota et al. Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche. Biochem Biophys Res Commun. 2007 Nov 26) histological assessment was performed of cells in hypoxic niches of the bone marrow. The investigators analyzed...
Brain Endothelium for Expanding Hematopoietic Stem Cells
Baltimore, MD - Expansion of human hematopoietic stem cells in the absence of differentiation would allow for development of autologous bone marrow transplants in a safe and reproducible manner. The problem is that to date, no protocol for expanding human hematopoietic stem cells has really been able to translate properly into the clinic. In a recent paper (Cheng X et al. Human brain...
No blood from muscle?
Villejuif, France - The concept of cellular plasticity has attracted many followers, as well as many critics. On the one hand, papers used to be published suggesting various forms of transdifferentiation, for example neurons becoming blood cells, or hematopoietic stem cells becoming cardiomyocytes. On the other hand, some...
Throwing Fuel on the Bone Marrow to Cardiac Fire
[Watch the Video] There are currently many clinical trials using bone marrow stem cells for regeneration of cardiac muscle. However, many scientists love to argue whether the bone marrow is actually differentiating into heart tissue, or if the bone marrow is simply providing "trophic" support. This video tries to discuss some of these issues.
Suppressor Stem Cells
Baltimore, Maryland - In the late 1960s to early 1970s, a type of immune regulatory cell called the "natural suppressor" cell was believed to exist associated with areas of hematopoiesis. Subsequent characterization of these cells revealed that they actually possess myelopoietic properties and inhibited immunity through secretion of factors such as TGF-beta and...
4 Comments