News Posts

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Cord Blood and Bone Marrow Turning to Liver

[Watch the Video] Although liver failure is treated on an experimental basis with the use of bone marrow stem cells, not too many people are aware of the preclinical evidence supporting such an approach. The video describes the use of bone marrow stem cells, as well as cord blood stem cells, for the differentiation into hepatic-like cells after administration into recipients with carbon...

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Double Whammy of Mesenchymal Stem Cells

[Watch the Video] The fact that mesenchymal stem cells are useful not only for regeneration of tissue, but also for blocking pathological immune responses is the subject of this video. The immune modulatory properties of mesenchymal stem cells allows them to be used for diseases such as arthritis, multiple sclerosis, diabetes, lupus, and other autoimmune conditions.

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Throwing Fuel on the Bone Marrow to Cardiac Fire

[Watch the Video] There are currently many clinical trials using bone marrow stem cells for regeneration of cardiac muscle. However, many scientists love to argue whether the bone marrow is actually differentiating into heart tissue, or if the bone marrow is simply providing "trophic" support. This video tries to discuss some of these issues.

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Remyelination by Stem Cells

[Watch the Video] This video describes the use of Schwann cell precursors to induce remyelination. Presented is a neat model of demyelination and specifics about how to use it to evaluate regenerative stem cell populations. This approach is useful for developing therapeutics for treatment of diseases such as multiple sclerosis.

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Stem Cell Expansion by Valproic Acid

[Watch the Video] This video overviews a paper describing the ability of valproic acid (a clinically used drug for treatment of neurological disorders) to induce expansion of hematopoietic stem cells. It will be interesting to see if valproic acid can also induce expansion of other types of stem cells in vivo.

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Immortal Neural Stem Cell

Milan, Italy - Immortalized stem cell lines are great tools for drug discovery in that they can be used for screening of chemical libraries for compounds that induce either self renewal or differentiation along a specific lineage. Therapeutically, despite oncogenic potential, differentiated stem cell lines have been used in clinical...

Monday June 11th, 2007 @ 23:45:40 EST

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HOXB4 synergizes with p21 KO

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Antipsychotic modulation of stem cells

Sapporo, Japan – Patients with schizophrenia are usually treated with antipsychotic drugs. Typical or atypical antipsychotics such as clozapine and olanzapine have been utilized with various degrees of success. The mechanisms of actions of these drugs are not completely known, although the majority do have dopamine modulatory activity. In a recent publication (Kurosawa et al. Olanzapine...

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Clinical Evidence of Bone Marrow Therapy for Liver Failure

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Tracking Neural Stem Cells

Stanford, CA - Scientific investigation of cellular therapy whether for regenerative purposes or for immune modulation (ie adoptive transfer of activated NK, LAK, or T cells) has always benefited from the ability to actually see where the implanted cells are going in an in vivo setting. In a recent paper (Guzman et al. Long-term monitoring of transplanted human neural stem cells in...

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