News Posts
Pancreatic Cancer Stem Cells
Wuhan, China - The concept of cancer stem cells has been around for a while. One could say that initially the concept of cancer stem cells was discovered in the hematopoietic system where the group of Dr Dick from Toronto was able to induce human leukemias in mice with injection of as little as 5-10 cells per mouse. Under normal circumstances if one takes leukemic blasts from patients and...Monday February 4th, 2008 @ 04:39:46 EST
BRCA-1 Involved In Breast Stem Cell Differentiation
Ann Arbor, MI - The concept of a stem cell found within tumor populations that maintains the tumor mass has been around for more than a decade. Patents one using stem cells for screening of new cancer agents have driven the recent GSK-OncoMed deal that in total could be worth approximately $1.5 billion. While it is obvious that...Friday February 1st, 2008 @ 04:03:58 EST
Ex vivo expanded Treg cells protection against allograft rejection
Chicago, IL, USA - Understanding methods of manipulating the immune system to accept allogeneic grafts without the continued need for immune suppression would not only solve the problem of organ transplant rejection but would also bring stem cell therapy (especially embryonic) closer to reality. One interesting method of bringing about such an "immunological tolerance" is through the...Tuesday January 29th, 2008 @ 03:51:17 EST
Breast cancer FGF-2 and VEGF calls in mesenchymal stem cells
Augusta, Georgia - It is believed by many that tissue resident stem cells subsequent to accumulating DNA damage lose proliferative controls and transform into tumors. For example, there is a classical study in which mice were infected with h.pylori and gastric cancer was allowed to develop. Strikingly, the gastric cancer was derived from bone marrow stem cells which had migrated to heal the...Tuesday January 29th, 2008 @ 03:01:42 EST
Velcade guides stem cells to bone
Boston, Massachusetts - Stem cell therapeutics are difficult to commercialize because of the need for cellular manipulation. Even business models that involve off the shelf universal stem cells have the issue that you need are selling an actual biologic product, a product that is very difficult to standardize and ensure quality...Sunday January 27th, 2008 @ 13:23:10 EST
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Stem Cells in Davos
[Watch the Video] Youtube made a video contest for best "new ideas" to change the world in 2008. The winning videos will be presented at the World Economic Forum at Davos. The idea here is that the world will be a better place if therapeutic implimentation of autologous bone marrow stem cells are supported by governments and businesses !! If you like the video please pass on to...Monday January 21st, 2008 @ 14:05:06 EST
Importance of the Injury Signal
Warsaw, Poland - The immune system is activated in response to Danger signals, which evoke various innate molecular pathways that culminate with inflammatory cytokine production and eventual activation of the adaptive immune system. Stem cells circulating in lymphatics have been implicated in recognizing classical danger signals...Wednesday January 16th, 2008 @ 18:02:21 EST
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CD133 glycosylated epitope of prominin-1 is marker for pancreatic stem cells
Brussels, Belgium - Numerous tissue have been described to have endogenous, tissue resident, stem cells. For example, cardiac tissues express a population of lineage negative, side population cells that can regenerate myocardium. These cells and their uses are claimed in US patent 7,097,833. The side population phenotype has...Tuesday January 15th, 2008 @ 12:33:21 EST
GSK buys into Cancer Stem Cell Vision
London, UK, Philadelphia, PA and Redwood City, CA - It was recently announced that the California venture capital backed company OncoMed has struck a deal with GlaxoSmithKline that could be worth up to 1.5 Billion in milestone payments alone, not counting royalties. Arguably this is one of the highest valued deals for a technology that is still preclinical. In order to give a background...Monday January 14th, 2008 @ 19:56:47 EST
Supercharged Mesenchymal Stem Cells
Kobe, Japan - The ability to expand stem cells in culture without their differentiation is one of the features that makes embryonic stem cells attract a lot of attention. For example, in one of the classical WARF patents, the claim is made regarding ability of the embryonic stem cell to proliferate in an undifferentiated state...Monday January 14th, 2008 @ 03:38:49 EST