News Posts
Hematopoietic Stem Cells Patrolling The Body for Danger
Boston, MA - A potentially new role for stem cells has been described. In most cases, various stem cells such as mesenchymal stem cells as well as hematopoietic stem cells possess immune suppressive characteristics. In a recent publication (Massberg et al...Wednesday December 5th, 2007 @ 11:20:16 EST
T regulatory cell control of bone resorption
Erlangen, Germany - Although mesenchymal stem cells are primarily known for their differentiation abilities, the first clinical trials, and most likely BLA grantings, will be for immune modulation by these cells in the conditions of graft versus host disease and Crohn's disease. In the same way thatGive Me Air: Hematopoietic Stem Cells in Hypoxic Niches
Tokyo, Japan - It is generally known that early, non-proliferative stem cell reserves are sequestered in hypoxic niches. In a recent paper (Kubota et al. Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche. Biochem Biophys Res Commun. 2007 Nov 26) histological assessment was performed of cells in hypoxic niches of the bone marrow. The investigators analyzed BrdU...Wednesday December 5th, 2007 @ 04:20:54 EST
CD133 on Lung Cancer Stem Cells
Rome, Italy - The targeting of drugs to tumors has historically been a difficult task for reasons such as poor vasculature and high interstitial pressure. More recent studies have described that not all tumor cells in a tumor mass are the same. Specifically some cells in the tumor mass have very high proliferative and self-renewal potential whereas others do not. These cells, which some call...Wednesday December 5th, 2007 @ 04:03:39 EST
Brain Endothelium for Expanding Hematopoietic Stem Cells
Baltimore, MD - Expansion of human hematopoietic stem cells in the absence of differentiation would allow for development of autologous bone marrow transplants in a safe and reproducible manner. The problem is that to date, no protocol for expanding human hematopoietic stem cells has really been able to translate properly into the clinic. In a recent paper (Cheng X et al. Human brain...Wednesday December 5th, 2007 @ 03:50:20 EST
No blood from muscle?
Villejuif, France - The concept of cellular plasticity has attracted many followers, as well as many critics. On the one hand, papers used to be published suggesting various forms of transdifferentiation, for example neurons becoming blood cells, or hematopoietic stem cells becoming cardiomyocytes. On the other hand, some...Friday November 30th, 2007 @ 03:45:30 EST
Liver Failure Regeneration: Its the quality of the injury that matters
Houston, Texas- There are numerous clinical examples of adult stem cells helping people or animals with liver failure. One of the ways in which mesenchymal stem cells help in liver failure is by their ability to produce IL-10 in response to stellate cell generated IL-6...Thursday November 29th, 2007 @ 21:57:03 EST
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Treg cells causing "alternative activation" of monocytes
London, UK - In immunology, the notion that T cells are activated by antigen presenting cells has been around for decades. At one time, it was believed that T cells are activated by "immune RNA" generated from antigen presenting cells, this immune RNA being able to "instruct" the T cell to go after specific antigens. Afterwards, the major histocompatibility molecules were demonstrated to...Thursday November 29th, 2007 @ 21:33:08 EST
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PSGL-1 and generation of tolerogenic dendritic cells
Madrid, Spain - The advancement of allogeneic stem cell research into the clinic has always been dependent on immunology. In other words, allogeneic stem cell therapy is dependent on ability of the clinician to manipulate the recipient immune system so that the allogeneic cells do not get rejected (host versus graft), nor that the recipient gets attacked by the cells administered (graft...Tuesday November 27th, 2007 @ 11:10:10 EST
Bone marrow stem cells in pulmonary hypertension
New Orleans, Louisiana - Adult stem cells have been used clinically in treatment of heart failure, liver failure, and advanced peripheral artery disease. One exciting possible use of stem cells is in the treatment of...Tuesday November 27th, 2007 @ 03:13:15 EST
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5 Comments