Class: Use (276)
Optimization of immunomodulatory properties of genetic vaccines
Patent Number: 7,390,619Activation of T cells normally occurs by antigen presenting cells, of which the dendritic cell is the most potent. T cells require signals from CD80 and CD86 on the antigen presenting cell in order to activate CD28, which is required for escape from anergy. Since the T cell molecule CTLA-4 also binds CD80 and CD86, it is important to preferentially...
Cumulus cells as nuclear donors
Patent Number: 6331659This patent provides the use of cumulus cells as donors of nuclei for the purpose of cloning animals with the exception of humans.
Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
Patent Number: 6328960This patent teaches the use of mesenchymal stem cells as biological immunosuppressants for prevention of graft rejection.
Antigen modified cancer cell vaccines for cancer therapy
Patent Number: 7,348,015This patent covers a way of "controlling or inhibiting blastoma cancer cell proliferation in a mammal" by vaccinating with tumor cells that express the Streptococcus pyogenes gene emm55. The natural function of emm55 appears to be in immune evasion of the complement system. Since tumor cells have mammalian complement inhibitory proteins, maybe the approach proposed by...
Treatment and diagnosis of alzheimer's disease
Patent Number: 7,189,703This patent covers the treatment of Alzheimer's disease by antibiotic therapy. Covered include various macrolides such as azithromycin, clarithromycin, dirithromycin, erythromycin and troleandomycin. The rationale is that Alzheimer's disease patients are infected with C. pneumoniae, which is demonstrated in the examples section. The inventor of the patent also published that C...
Methods using lineage restricted glial precursors from the central nervous system
Patent Number: 7,214,372Neurodegenerative diseases such as multiple sclerosis cause pathology, in part, through demyelination. Since the myelin sheath acts as an insulator of nerves, when the nerves are demyelinated, they cease proper function. The current patent covers the use of glial restricted precursors, as well as oligodendrocyte differentiated glial restricted precursors, for remyelination of nerves. These...
Methods of creating constructs useful for introducing sequences into embryonic stem cells
Patent Number: 6815185This patent provides methods and vectors for transfection of embryonic stem cells. This patent is useful for generation of various animal research models that have a genetic modification introduced into the whole animal. Additionally, transfection of embryonic stem cells could be useful for a variety of different things, including using the embryonic stem cells as a vector...or in another...
Kits for treatment of hematologic disorders
Patent Number: 7,408,039Hematopoietic stem cell transplantation has saved many lives of patients with hematological and metabolic malignancies. Unfortunately, one of the major side effects of this treatment is graft versus host. The company Osiris is in advanced stages of clinical trials (Phase III) using mesenchymal stem cells to treat this condition in which lymphocytes from the donor start attacking the...
Genetic modification of male germ cells for generation of transgenic species and genetic therapies
Patent Number: 7,294,755Usually transgenic animals are generated by ex vivo modification of female genetic materials and implantantion into a receptive recipient. In the current patent a different approach is taken to generation of transgenic or genetically modified animals. The patent covers the in vivo genetic modification of male gametes and subsequent mixture of the male genetic material with an unmodified...
Prevention of immunoreactivity by depleting or inhibiting antigen presenting cells
Patent Number: 7,288,255Graft versus host disease occurs after administration of allogeneic hematopoietic stem cell grafts. Essentially, graft versus host represents contaminating T cells from the graft attacking various tissues of the recipient. In some cases graft versus host disease is lethal. In fact, graft versus host disease is one of the largest causes of hematopoietic stem cell transplant associated...
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