Class: Use (276)
Methods for reducing adverse side effects associated with cellular transplantation
Patent Number: 6387366This patent teaches ways how to overcome some of the negative effects associated with cell therapy in regards to excessive coagulation. It is stated in the specification that in many cases the administration of a cellular therapy results in coagulation of blood due to expression of pro-clotting agents on the surface of the administered blood cells such as tissue factor. The patent teaches...
Bone resorption inhibitors
Patent Number: 6723696This patent covers a novel factor that on the one hand is involved in leukocyte activation, and on the other hand inhibits bone resorption. This factor is useful in conjunction with stem cell therapies that stimulate bone formation.
Assessing the condition of a joint and devising treatment
Patent Number: 7,239,908In stem cell therapy it is not only important to have the right types of stem cells, but it is just as important to know the proper indication and stage of the progression of the indication when intervention is most likely to yeild benefit. This is what the current patent is covering in the area of joint degeneration.
The patent covers very interesting methodologies for convering
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Methods and compositions for modulating neurodegeneration
Patent Number: 6664039This patent provides a peptide sequence composition of matter that is useful for treatment of neurodegeneration, in part through the stimulation of neural stem cell proliferation. Agents involved in stimulation of neural stem cells are important not only for obvious reasons, but also because they may also stimulate hematopoiesis. The specific peptide claimed in this patent is called "very...
Methods and articles for regenerating bone or peridontal tissue
Patent Number: 6409764This patent provides methods of using stem cells to generate an artificial bone. Various stem cells are able to be used in the context of this invention, including mesenchymal stem cells. This invention also uses members of the TGF beta family in combination with specialized artificial matrices.
Uses of fibroblasts or supernatants from fibroblasts for the suppression of immune responses in transplantation
Patent Number: 7,491,388We know that mesenchymal stem cells are immune modulatory through a variety of means such as secretion of HLA-G, expression of indolamine 2,3 deoxygenase, and production of immune suppressive cytokines. What is relatively understudied is the immune regulatory activities of fibroblasts. For...
Method of treating coronary artery disease by administering FGF-4
Patent Number: 7,511,019Stimulation of angiogenesis for treatment of ischemic conditions would provide therapeutic solutions for conditions such as heart failure, peripheral artery disease, and even stroke, in which post-injury angiogenesis plays a major role. Some companies, such as Medistem, are using cells such as the Endometrial Regenerative Cells (ERC) to stimulate...
Method of treating coronary artery disease by administering a recombinant FGF
Patent Number: 6451303There are more than 20 members of the fibroblast growth factor family. Many of the FGF proteins are involved in activation of stem cell proliferation, as well as induction of angiogenesis. This patent covers the treatment of coronary artery disease, for example ischemia induced by it...through the stimulation of angiogenesis by administration of
Transplantation of neural cells for the treatment of chronic pain or spasticity
Patent Number: 6444205This patent covers administration of GABA producing neurons or neural stem cells from a fetus into a patient with chronic pain or spasticity. This patent covers not only human donor sources but also porcine. The ability to generate different types of pigs through genetic engineering may allow for some of these approaches to enter the clinic. One such particular...
Methuselah gene, compositions and methods of use
Patent Number: 6303768Methuselah is a gene, which certain variants of it are associated with life extension. The mechanisms of action are not completely known, however it appears that it acts along the pathway of reducing cellular metabolic stress.