Class: Use (276)
Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
Patent Number: 6864235The ability of cells to respond to danger signals is associated with how the host will respond to injury in general. This patent is based around observations that cellular injury is associated with upregulation of certain danger signal associated molecules, which the inventors call "transition molecules". This is most likely why the name of one of the companies that the inventors established...
Treatment of brain damage
Patent Number: 7,247,298This patent covers the use of neuroepithelial stem cells for treating brain damage. The claims specifically encompass conditionally immortalized cells and their administration into areas contra-lateral to the region where brain damage as occured. The point the the cells have activity when administered in the contralateral region is very interesting. The patent specifically defines...
Isolated stromal cells for use in the treatment of diseases of the central nervous system
Patent Number: 6653134This patent teaches that one can induce the differentiation of stromal stem cells into neural cells, through the culture of the stromal cells with differentiated neural cells. This patent is useful not only for generating cells for treatment of neurological conditions, but also may be used to begin elucidating what the specific signals are that the neural cells use to teach the stromal stem...
Cell-based gene therapy for the pulmonary system
Patent Number: 6482406This patent covers the transfection of various cells and their administration in order to heal various pulmonary lesions or disorders. In one utilization, cells are transfected with iNOS and used to administer nitric oxide directly into the lung of patients with pulmonary hypertension.
Implant for repairing cartilage having outer surface layers of copolymer and ceramic material
Patent Number: 6737073This is an implantable matrix that can be used for growing stem cells in vitro for the regeneration of cartilage. The implant has several advantages over the prior art including the fact that it is compartamentalized in structure to provide a more "in vivo" like function.
Methods and compositions for healing and repair of articular cartilage
Patent Number: 7,323,445This patent covers the regeneration of articular cartilage by administering an osteochondral graft together with purified bone morphogenetic protein (BMP) selected from the group consisting of BMP-2, 4, 5, 6, and 7 and one protein which induces the formation of tendon or ligament tissue selected from the group consisting of BMP-12,
Methods and compositions for healing and repair of articular cartilage
Patent Number: 6727224This patent teaches the use of bone morphogenic proteins together with stem cells for repair of articular cartilage injury. In some embodiments the stem cells may be endogenous.
Method of determining cytokine dosage for improving myelosuppressive state
Patent Number: 7,465,551Since everyone is different in general, it makes little sense that people usually are all given "standard doses" of various medicines. Ideally one would like to be able to tailor doses to the specific needs of the patient. Thats what this patent covers.
The patent covers "A method of determining a dose of G-CSF to be administered to a patient before or after... In the spirit of Labcorp v Metabolite this patent covers methods of assessing a phenomena and based on this assessment intervening appropriately. If you read the case you will see where we are going with this.
The patent covers the monitoring of various hematopoietic cytokines in order to assess myelosuppression... After chemotherapy or radiation therapy, the myeloid compartment of the immune response is suppressed, due to destruction of the myeloid stem cell compartment. This patent provides a kit that allows the determination of myelosuppression, and therefore can be used to guide the amount of myelo-stimulatory therapy (ie G-CSF) that should be administered. The kit measures alone or in combination... 
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Method of evaluating myelosuppressive state
Patent Number: 7,279,289
Method of evaluating myelosuppressive state
Patent Number: 6649352