Class: Use (276)
Method and system for myocardial infarction repair
Patent Number: 6775574This patent covers the implantation of a stem cell source, or genes associated with stem cells and regeneration, together with a pace-maker type device, into a patient whose heart is in need of regeneration. The advantage of this patent is that numerous times the implanted cells do not beat in synchronism with the host cardiac cells, this patent tries to overcome this problem.
Method and system for myocardial infarction repair
Patent Number: 6671558This patent covers a method of preventing heart failure after a myocardial infarction through the administration of stem cells, together with a device that induces electrical signals. In some embodiments the stem cells are transfected with genetic material to modify functions (ie increased contractility: transfect with SERCA-2, increase angiogenesis: transfect with...
Nuclear transfer using cells cultured in serum starvation media containing apoptosis inhibitors
Patent Number: 6635802This patent teaches the use of antiapoptotic agents, and serum starvation, of the recipient cells for nuclear transfer. This can be used to generate autologous embryonic stem cells.
Liver regeneration using pancreas cells
Patent Number: 6132708While some patents cover the generation of islet like cells from hepatocytes by transfection with PDX-1, this patent covers the generation of live cells through insertion of pancreatic cells into the spleen (in one embodiment). If anything, this patent attests to the plasticity of various cellular populations.
Use of marrow-derived glial progenitor cells as gene delivery vehicles into the central nervous system
Patent Number: 7022321This patent capitalizes on the ability of bone marrow cells to migrate into the brain and cause repairative function. The patent uses bone marrow cells as a "vector" in order to deliver glial cell line-derived neurotrophic factor (GDNF) to the area of need. The patent has 2 independent claims both covering "A method of treating Parkinson's disease, ". The first covers administration of...
Composition comprising multipotent neural stem cells for generation of hematopoietic cells
Patent Number: 6897060Antigen presenting mesenchymal stem cells
Patent Number: 7101704This patent covers mesenchymal and adipocyte lineage cells that have been induced to present exogenous antigen. The patent is useful for companies that are interested in stimulating an immune response through having the mesenchymal or adipocyte-lineage cell to act as an antigen presenting cell. The patent has 2 independent claims. The first covers mesenchymal stem cells that have been...
Methods of cancer therapy targeted against a cancer stem line
Patent Number: 7,361,336The concept of the cancer stem cell revolves around the notion that 99% of cells making a tumor mass, while deadly, are not the ones that keep the tumor growing. The <1% of cells of a tumor, which possess unique surface markers and functional activities are the ones that continually cause the tumor to keep growing. According to this idea, drug development in cancer for the past 50...
Genetic engineering of cells to enhance healing and tissue regeneration
Patent Number: 6398816This patent teaches the use of mesenchymal stem cells transfected with "bioactive molecules" (ie cytokines, growth factors, etc), so as to induce repair of bone, cartilage, or connective tissue.
Genetic engineering of cells to enhance healing and tissue regeneration
Patent Number: 6077987This patent covers the induction of healing through administration of mesenchymal stem cells alone, or mesenchymal stem cells after transfection with other genes.