Class: Use (276)
Methods for treating cancer using allogeneic lymphocytes without graft vs host disease activity
Patent Number: 6213127This patent teaches ways of administering allogeneic lymphocytes that have been treated chemically or with radiation so as to elicit an antitumor effect while at the same time not causing graft versus host.
Neural stem cells and use thereof for brain tumor therapy
Patent Number: 7,186,409The current patent teaches that exogenous neural stem cells can migrate to the area of various brain cancers. The patent covers the use of neural stem cells as a trojan horse to carry enzymes that activate prodrugs into active drugs in proximity to a tumor in order to induce cancer cell death.
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Treatment for diabetes
Patent Number: 6558952This patent teaches how to induce endogenous islet stem cells to multiply through administration of gastrin together with a ligand of the EGF receptor such as TGF alpha. One of the principles behind the current company doing clinical trials with this, Dr Tony Cruz, is also involved in the company Stem Cell Therapeutics, which is performing...
Method for reducing neuronal degeneration so as to ameliorate the effects of injury or disease
Patent Number: 7,560,102This patent teaches methods of stimulating nervous system regeneration by activating an immune response against the nervous system. Specifically, stimulation of immunity against antigens in the central nervous system such as myelin is associated with induction of autoimmunity, for example in the animal model of multiple sclerosis called experimental allergic... It is believed that neural stem cells are found in large quantities in the ependyma (the thin epithelial membrane lining the ventricular system of the brain and the spinal cord canal). The ependyma is one of 4 types of neuroglia and its primary function is the production of cerebrospinal fluid.
The current patent covers the assessment of test compounds for modulation of... This patent covers the use of neural stem cells for enhancing activity of hematopoietic stem cells. This patent attests to the similarity, if not synergy, between the neural stem cell system and the hematopoietic stem cells system. This patent is useful for drug development. It teaches ways of inducing gene expression in cells (including stem cells) and using the specifically modified cells for screening of drug libraries. The invention itself is not specific to stem cells, so therefore we will not describe it in detail. The patent has 3 independent claims. Specifically:
"A method of screening for cells having an... This patent teaches the use of skeletal myoblast, muscle stem cells, for treating urinary incontinence. The cells may be used without modification, or may be genetically engineered to express therapeutic genes. Examples of therapeutic genes include nerve growth factor, nitric oxide, etc. This patent covers a method of treating a neurodegenerative condition through administration of neuronal stem cells into the cholinergic basal forebrain that have been transfected with nerve growth factor or a neurotropin.
This patent uses the natural ability of neural stem cells to migrate to the place where they are needed, in order to deliver the protein that is produced from the gene... This patent covers mesenchymal stem cells that are treated with interferon gamma for suppression of an immune response. Mesenchymal stem cells are naturally immunosuppressive...it may be that the interferon gamma treatment is activating the expression of the immune suppressive enzyme 2,3-indolamine-dehydrogenase (IDO), which selectively depletes tryptophan, thus stopping T cell...
Method of isolating ependymal neural stem cells
Patent Number: 7,279,332
Use of multipotent neural stem cell progeny to augment non-neural tissues
Patent Number: 6638501
Methods and compositions for screening for altered cellular phenotypes
Patent Number: 7056687
Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
Patent Number: 6866842
Methods for therapy of neurodegenerative disease of the brain
Patent Number: 6451306
Mesenchymal stem cells as immunosuppressants
Patent Number: 6797269