Class: Use (276)
Antibody to stem cell factor
Patent Number: 7,285,640This is a composition of matter patent on an antibody to stem cell factor. Since stem cell factor is involved in asthma, this is one of the proposed uses in the specification. Given that stem cell factor is also involved in numerous malignancies such as GIST, this patent may have many uses.
Method of culturing cells to produce a tissue sheet
Patent Number: 7,166,464The ability to generate monolayers of cells is important for a variety of tissue engineering applications. Most notably is the need to generate monolayers that can be placed on medical devices such as stents in order to allow increased compatibility and decreased rates of restenosis. The current patent teaches ways of culturing cells, including stem cells, in a monolayer and methods of...
Transgenic non-human mammals as models for human pathologies of stem cell origin
Patent Number: 7,456,333Chronic myeloid leukemia is characterized by a chromosomal translocation resulting in production of the bcr-abl fusion protein, which is believed to be responsible for initiation of the malignancy. Vaccination against bcr-abl peptides has been associated with some clinical benefit, and small molecule targeting of this protein has...
Composition and method for treating graft-versus-host disease
Patent Number: 7,173,016Graft versus host disease (GVHD) is one of the major limitations of bone marrow, or for that matter, any type of allogeneic hematopoietic stem cell transplant. Essentially, GVHD is the result of donor derived T cells attacking the allogeneic recipient. Previously attempts were made to reduce GVHD by “purging” the stem cell graft of T cells...
Remedies for ischemic disease
Patent Number: 7,473,425This patent essentially covers the combination of G-CSF with HGF, together with a clinically used pharmacotherapy, for the treatment of ischemic disease of a limb. Classically it has been difficult to induce therapeutically significant angiogenesis using single angiogenic compounds. Some companies are using cells as secretors of angiogenic... This is a patent covering the use of CD34+ generated mast cells for drug screening. Since technologies for generating mast cells existed in the prior art (for example, as early as 1991 it was known that CD34+ cells can differentiate into mast cells: Kirshenbaum AS, et al. Demonstration of the origin of human mast... Cord blood derived stem cells represent a potent source of young, pluripotent, cells. Although previously their use was restricted to hematological malignancies, newer studies have demonstrated cord blood cells may be useful for many regenerative purposes, such as Ethicon's patent #7,413,734 which teaches use of cord blood stem cells for treatment of... This patent teaches ways of generating an plethora of compounds which are useful for regeneration of damaged nervous system tissue. Specifically, the patent has 2 independent claims. The first covers growing nerves in conditions that are not associated with degeneration, then killing the nerves, harvesting the material, and introducing the material into an area where damaged neurons are... Numerous ways exist of augmenting angiogenesis. These range from administration of cytokines such as FGF (US Patent #6451303) to administration of cells (US Patent 5980887). The current patent teaches the administration of endothelial... This patent covers the use of a novel stimulator of natural killer t (NKT) cells which are known to be involved in activation of both dendritic cells and T cells. Interestingly NKT cells are also involved in the liver and possibility development of fibrosis. The first independent claim of this patent is "A...
Production of cultured human mast cells and basophils for high throughput small molecule drug discovery
Patent Number: 7070996
Composition for treatment of articular cartilage damage
Patent Number: 7,459,307
Materials and methods for nerve grafting, selection of nerve grafts, and in vitro nerve tissue culture
Patent Number: 6972168
Endothelial precursor cells for enhancing and restoring vascular function
Patent Number: 7,135,171
Use of glycosylceramides as adjuvants for vaccines against infections and cancer
Patent Number: 7,488,491