Class: Use (276)
Anti-scarring ribozymes and methods
Patent Number: 7,462,602Bone marrow stem cells have been demonstrated to have some degree of anti-fibrotic effect. For example, after myocardial infarct, bone marrow infusion has been demonstrated to decrease non-viable myocardial scar tissue formation. Additionally, bone marrow administration has been effective in pilot trials of hepatic fibrosisInventors: Schultz; Gregory S. (Gainesville, FL), Lewin; Alfred S. (Gainesville, FL), Blalock; Timothy D. (Boston, MA)
Cellular therapy to heal vascular tissue
Patent Number: 7,387,645The current patent covers methods of treating/repairing aneurysms through autologous cells, including stem cells by delivering the cells into an aneurysmal site so as to repair the blood vessel. Types of cells useful for practising the invention include bone marrow stem cells, adipose derived stem cells and blood derived stem cells. Addition of various extracellular matrix...
Erythropoietin administration to improve graft survival
Patent Number: 7,459,152The non-hematological uses of erthrypoietin are very interesting. Studies have demonstrated that erythropoietin can accelerate cardiac healing after infarct, or even have a therapeutic effect on stroke.
The current patent teaches that erythropoietin may be used in conjunction with transplantation of dopaminergic cells in the treatment of Parkinson's Disease. Essentially...
Methods and compositions to treat myocardial conditions
Patent Number: 7,294,334Myocardial infarctions cause massive lose of cardiac muscle, as well as cause numerous electrophysiological dysfunctions that can immediately or in the long-term lead to death. The current patent has 2 independent claims that deal with this. The first one teaches the application of a pacing therapy in the infarct area together with the percutaneous administration of porcine "donor...
Therapeutic cellular stent
Patent Number: 7044965This patent covers a type of stent that contains cells and is useful not only for maintaining open a blood vessel, but also for delivery of cells that secrete various agents useful for the body. The patent has two independent claims, the first covering a stent containing cells, the second covering a method of administering cells into an organism. Stents have been covered with many agents in...
Cell-based therapies for ischemia
Patent Number: 7,470,538The successful use of adult stem cells for treatment of cardiac conditions such as heart failure and post infarct recovery has been documented in animal studies and clinical trials. The current patent covers the use of one type of adult stem cell, cord blood stem cells for use in increasing perfusion in the...
Cardiac stimulation system with delivery of conductive agent
Patent Number: 7,317,950This patent covers a device that stimulates conductivity of electrical signals in the heart. Amongst the uses of the invention is to ensure proper biventricular septal pacing. The invention claims the use of various cells, including stem cells, for increasing certain conductivity connections.
Keratinocytes useful for the treatment of wounds
Patent Number: 7,306,943Although the patent describes a keratinocyte population, the fact that the cells claimed can proliferate past the Hayflick limit, stimulated us to discuss this patent. The use of allogeneic cells for covering burns and other types of wounds has been widely known in the art, however in the current patent a type of keratinocyte with immense proliferative potential is described. The patent...
Quantitative RT-PCR to AC133 to diagnose cancer and monitor angiogenic activity in a cell sample
Patent Number: 7,252,976Based on the title, one would think that this patent covers global use of PCR amplifying for CD133 transcripts in order to detect angiogenic propensity in a host. If this were the case, then the patent indeed would be very strong.
The patent, however, is restricted to covering the diagnosis of colorectal cancer using PCR... This patent covers methods of making genetically engineered pigs. This is an important area of study not only from a research perspective, but also that transgenic animals may be used for things such as: a) mass production of proteins; b) donor organs for humans; and c) agricultural purposes. The patent teaches the generation of pigs by: 1. Obtaining a pig ES cell...
Nuclear transfer with porcine embryonic stem cells
Patent Number: 7,371,922