Class: Use (276)
Composite bone marrow graft material with method and kit
Patent Number: 6723131This patent teaches how to administer bone marrow in vivo, so that administration is performed not only of hematopoietic stem cells, but also stromal elements. This combination should be useful in patients whose stroma has been destroyed for one reason or another. The invention may also be useful for prevention of donor-derived leukemic relapse.
Animal tissue with carbohydrate antigens compatible for human transplantation
Patent Number: 7,126,039This patent teaches ways of inactivating xenogeneic carbohydrate antigens and replacing them with non-immunogenic antigens so that various porcine and animal tissue may be transplanted into humans without the fear of hyperacute rejection. Since the problem of allogeneic rejection is still an issue, the clinical translation of this technology will most likely be long-term. Specifically, if...
Methods of treatment of hematopoietic disorders
Patent Number: 7,347,999This patent covers a "method of treating a mammal suffering from a hematopoietic disorder wherein bone marrow transplantation is required" through the administration of bone marrow cells and a bone matrix. The patent is interesting since it covers into only administration into the bone but also in sites outside of the bone. The patent covers various additives that can be...
Pharmaceutical preparation for the treatment of topical wounds and ulcers
Patent Number: 6555118This patent covers extracts from certain plants for the regeneration of skin tissue after wounding. The patent is useful not only for generation of a new topical product, but also for identification of potentially novel stem cell stimulators found in the concoction.
Herbal composition for treating CD33+ acute and chronic myeloid leukemia and a method thereof
Patent Number: 7,306,817Myeloid leukemias are known as conventional "stem cell malignancies" in that there is unequivocal evidence that the cell causing the propagation of the neoplasia is a transformed stem cell. This was what led to the discovery of tumor stem cells in solid tumors many years after.
In the current patent a method of treating
High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation
Patent Number: 7,354,729This patent covers specific conditions for assessing ability of hematopoietic stem cells to proliferate or become metabolically active after exposure to a test agent in vitro. Essentially the patent is useful for the screening of small molecules using high throughput systems for identification of hematopoietic stem cell modulators.
Specific hematopoietic stem cells covered in the...
Physiological tissue repair and functional organ regeneration by cultivation of regenerative stem cells in vivo and in situ
Patent Number: 6991813This patent covers a way of stimulating healing by treatment with a neutraceutical. Specifically the patent has 1 independent claim covering a method for regenerating skin through administration of a composition on a wound having beeswax a fatty acid-containing oil and a sterol compound. The patent claim is directed toward stimulation of proliferation of keratinocytes that express...
Methods for altering cell fate to generate T-cells specific for an antigen of interest
Patent Number: 7,491,534The concept of taking one cell and turning it into another cell has been reported and even patented in certain situations, however, it is still difficult to see examples of wide-spread use of such techniques. For example, patent #6,087,168 covers transdifferentiation of epidermal cells into neurons by transfection with some specific neuronal transcription...
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Methods for providing differentiated stem cells
Patent Number: 6576464It is well known that embryonic stem cells can cause cancers called teratomas. This patent teaches the transfection of embryonic stem cells with suicide genes so that after the embryonic stem cell or its differentiated progeny are introduced into the body, they can be induced to kill themselves after having performed their effects. Of course we all know that cells mutate and even one small...
Artery smooth muscle- and vein smooth muscle-specific proteins and uses therefor
Patent Number: 7,163,808The use of stem cells for stimulation of angiogenesis is of great interest to current researchers. The ability of stem cells to stimulate angiogenesis is dependent not only on differentiation of stem cells into endothelial cells, but also by virtue of stem cell secreted growth factors that promote localized tissue remodeling and proliferation of endogenous endothelial precursors. The...