Class: Use (276)
Use of human embryonic stem cells for drug screening and toxicity testing
Patent Number: 7041438This is a very broad patent that essentially covers all drug screening using a specific type of stem cells. The inventors describe these stem cells as "primate Pluripotent Stem cells" (pPS cells), thus including pre-embryonic, embryonic, or fetal tissue-derived cells that can be induced to differentiated into progeny of the three germinal layers: endoderm, mesoderm, and ectoderm. This...
Autogenous cell patch cardio myoplasty and advanced muscle graft implantation system
Patent Number: 6435190This patent teaches what appears to be a surgical method for producing an autograft that can cover lesions in the heart. This is important since after a heart attack, there is scar tissue formation, and the heart starts to lose function. The patent also covers ways in which autologous stem cells may be administered.
Method for enhancing engraftment of cells using mesenchymal progenitor cells
Patent Number: 7,442,390Stem cell transplantation in the form of cord blood, mobilized peripheral blood, or bone marrow, has saved many lives. One of the limiting factors of this procedure is graft versus host disease (GVHD). The other is poor engraftment. This is particularly important in situations...
Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state
Patent Number: 7049072It is known from the literature that the non-tumor stroma surrounding the tumor plays an important role in the growth of the tumor by facilitating angiogenesis, providing growth factors, etc. In hematological malignancies, the fact that donor-derived leukemic relapse occurs in some individuals suggests that stromal elements may be responsible, or associated with leukemic transformation...
Surface modifications for enhanced epithelialization
Patent Number: 6689165This patent teaches how to accelerate healing of epithelial cells of the cornea through administration of an optical polymer that consists, in part of a hydrogel. The devices and compositions thought are useful for stimulation of stem cells associated with production of corneal epithelial cells.
Neuroprotective peptides
Patent Number: 7,259,146This patent covers specific peptides derived from erythropoietin, as well as from other molecules, that have ability to increase neurite outgrowth in cell culture. Specifically, the claims appear to be restricted only to a method of increasing neurite outgrowth in cell culture. The neuroprotective roles of erythropoietin have been known for many years and have been assessed and are being...
Microinjection of cryoprotectants for preservation of cells
Patent Number: 7094601This patent is useful for cryopreservation of extremely sensitive cells such as oocytes and stem cells. Particularly, the patent deals with microinjection of various agents that protect cells during cryopreservation. The patent has 2 independent claims. The first covers the culture of oocytes (the concept that "culture" will be frozen) such that a cryopreservation agent is injected...
Conditioned cell culture medium compositions and methods of use
Patent Number: 7,118,746This patent covers protection of keratinocytes from a variety of stresses by administration of conditioned media from a variety of stem cell sources. This patent is useful for cosmetics and also for skin regeneration.
Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions
Patent Number: 7,431,932Activation of innate immune responses is associated in some situations with anti-tumor effects. It is known that viruses activate various cells of the innate immune system such as interferon producing plasmacytoid dendritic cells and natural killer cells. In tumor immunology, it would be...
Treatment of disorders by implanting stem cells and/or progeny thereof into gastrointestinal organs
Patent Number: 6808702This patent is very interesting in that it provides a source of nitric oxide through the use of fetal and embryonically derived neural stem cells. The neural stem cells can be administered by various means in order to correct gastrointestinal deficiencies.