Class: Use (276)
Methods for treatment of vascular disease and device for preparation of an autologous composition for treating vascular disease
Patent Number: 6623733While some patents use cell supernatant for induction of biological activities, this patent goes all out and uses cell lysates! This patent covers the use of various cell lysates, including of stem cells, in order to augment stem cell proliferation as well as angiogenesis.
Method for remyelinating a demyelinized lesion due to injury in the brain or spinal cord
Patent Number: 7098027This patent is useful for inducing remyelination using autologous bone marrow stem cells. Demyelination is a pathology associated with numerous neuronal degenerative diseases such as multiple sclerosis or Krabbe Disease. The patent has 1 independent claim which covers the methodology of extracting bone marrow mononuclear cells from the autologous patient and injecting into the lesion of...
Liver engrafting cells, assays, and uses thereof
Patent Number: 7,211,404Hepatic diseases are a major scourge on our society. Currently great progress has been made through the use of autologous bone marrow stem cells for treatment of these diseases. In the current patent, a cell that is capable of engrafting in the liver is disclosed. the cell is of hepatic origin and is positive for 5E12 and/or Ep-Cam and/or CD49f and/or E-Cadherin...
Method of enhancing myogenesis by electrical stimulation
Patent Number: 7,483,749Stem cells act as part of the endogenous repair processes of the body. For example, after heart attacks specific populations of stem cells leave the bone marrow and are attracted to the heart, presumably to regenerate the injured myocardium. Interesting new stem cell populations such as the VSEL stem cell population have...
Gene transfer into primate embryonic stem cells using VSV-G pseudotyped simian immunodeficiency virus vectors
Patent Number: 7,323,337This patent covers methods of transfecting embryonic stem cells. Specifically, it claims the use of SIV genetically engineered so that the nucleic acid which is being transfected is packaged into an SIV virion. Specific proteins and strains of SIV are covered that are useful for transfection. Numerous techniques for...
Method of testing myelotoxicity with the use of flow cytometer
Patent Number: 7,300,763Development of chemotherapeutic drugs is dependent on proper animal preclinical toxicology systems. These systems are very important since chemotherapeutic drugs usually have a very small margin in which tumor toxicity is achieved but healthy tissue is not completely destroyed. One of the first body systems to go during chemotherapeutic dose escalation is the hematopoietic system. This...
Methods and compositions for diagnosing and monitoring transplant rejection
Patent Number: 7,235,358As science progresses to the point of inducing specific differentiation of cellular products from embryonic stem cells, the issue of allogeneic rejection will have to be dealt with. This specific patent provides various inflammatory markers that are useful for knowing when a rejection episode will occur. By identifying when a transplanted cellular product starts undergoing rejection, it...
Genes with ES cell-specific expression
Patent Number: 7,250,255Genes associated with pluripotency, or "stemness" are very important not only from a scientific research perspective, but also from the perspective of clinically developing stem cell therapeutics. Specifically, during clinical development of any biological, it is important to possess numerous quality control assays. The current patent covers a novel gene whose expression seems to be...
Use of osteopontin for the treatment and/or prevention of neurologic diseases
Patent Number: 7,297,099Osteopontin is a cytokine molecule that is involved in tumor metastasis and various immune functions.
In the current invention, osteopontin is used to treat chemotherapy-induced neurotoxicity. This is essentially a next step from the previous work of the same inventors who previously patented the use of osteopontin for... In the manufacture of various implantable medical devices it is important that the said device be able to endothelialize so that it integrates successfully with the host. When this doesn't happen various problems may arise such as restenosis, or inflammation at the site of device implantation.
The current patent teaches that coating of devices with osteoprotegerin can be used to cause...
Methods and devices for promoting endothelial morphogenesis
Patent Number: 7,198,798