Class: Use (276)
Methods and compositions for treating intervertebral disc degeneration
Patent Number: 6723335This patent covers the use of a fluid matrix together with stem cells, specifically mesenchymal stem cells, for the regeneration of the nucleus pulposus. This invention is suitable for treatment of patients with lower back pain due to disc degeneration.
Growth factor therapy mobilization of stem cells into the peripheral blood
Patent Number: 7,291,597This patent covers the use of inhalation therapy of cytokines (FGF-1,2 and VEGF) for mobilization of stem cells. The patent is similar to patent 7,288,521 which was discussed last week.
Cardiac valve replacement
Patent Number: 6652583This patent teaches how to use stem cells and other differentiated cells in order to generate a heart valve that can be used for replacement of defective valves in patients suffering from various valvular abnormalities. The advantage of this biological valve is that it conceptually is longer lasting than completely artificial or xenogeneic valves.
Blood and cell analysis using an imaging flow cytometer
Patent Number: 7,522,758This patent covers methods of diagnosing diseases based on flow cytometric profile. Although the majority of the invention is directed towards chronic lymphocytic leukemia (CLL), the first claim is rather broad:
"A method for detecting a disease condition from images collected from a population of cells, comprising the steps of: (a) spectrally dispersing light from the... This patent teaches how to treat neurological damage through administration of stem cells into the contralateral hemisphere of the brain. This patent teaches activation of cardiac healing processes through reducing levels of thyroid hormone. This patent seems to depart substantially from the common notion that thyroid hormone is actually beneficial for the heart. For example, it is published that reducing thyroid hormone by administration of propylthiouracil actually leads to cardiac atrophy, angina and general deterioration... There is currently great interest in the use of cord blood stem cells for neuroregenerative purposes. This patent covers the ex vivo growth of cord blood cells in EGF, FGF2, NGF, and retinoic acid in order to generate a population of cells that contain neuronal-like properties.
Evidence of activity of these neural precursors is provided in the examples section... Telomerase is an enzymatic complex that repairs the telomeric ends of chromosomes so as to allow certain cells to escape senescence. Various stem cells, including some adult stem cells, express telomerase. Most importantly, tumors express this complex and it is what allows them to continue proliferating without undergoing senescence. A very interesting... This patent covers the use of xenogeneic islet cells derived from fetal or neonatal pigs -20 to +10 days after birth, treating the cells with nicotinamide, lignocaine and a quinolone antibiotic, in order to generate a population of cells that may be encapsulated and used for treatment of diabetes in a human.
This patent covers the use of antibodies to Tie-1 and glypican-3 for the treatment of cancer, presumably by selective killing of cancer stem cells. Tie-1 is one of the receptors for angiopoietin, which is activates endothelial cells and is critical in formation of new blood vessels (angiogenesis). Glypican-3 is a heparan sulfate proteoglycan that is anchored to the cell membrane...
Treatment of brain damage
Patent Number: 6569421
Methods and compositions for healing heart wounds
Patent Number: 6852706
Human cord blood as a source of neural tissue for repair of the brain and spinal cord
Patent Number: 7,160,724
Composition and method for inducing and enhancing a telomerase reverse transcriptase-reactive cytotoxic T lymphocyte response
Patent Number: 7,388,071
Preparation and xenotransplantation of porcine islets
Patent Number: 7,122,177
Methods of cancer diagnosis and therapy targeted against a cancer stem line
Patent Number: 7,427,400