Class: Expansion (424)
Epidermal differentiation factor
Patent Number: 5981220This patent covers a protein that stimulates stem cell differentiation into epidermal cells. The protein is useful for a variety of regenerative purposes, either alone or in combination with exogenous stem cells.
Histone deacetylases, and uses related thereto
Patent Number: 6777217This patent appears to be a composition of matter patent on various histone deacetylases. These proteins, histone deacetylases, are very important in controlling gene expression. Typically histone deacetylases suppress gene expression by deacetylazing histones, which control large parts of the DNA. Since histone deacetylase inhibitors actually stimulate expression...
Cell structure media for mammalian cells
Patent Number: 6413772This patent teaches methods of expanding hepatic stem cells, and hepatocytes in culture through a specialized type of serum free media. This media is useful for clinical applications and may be an important part in cellular therapy of hepatic disorders.
Cell culture media for mammalian cells
Patent Number: 6043092This patent covers a specific tissue culture media that is useful for the expansion of hepatocytes. The media is a serum free media and can be used for clinical applications.
Hematopoietic cell culture nutrient supplement
Patent Number: 6733746This patent covers a tissue culture media useful for the expansion of CD34+ hematopoietic stem cells that does not require the use of serum, and thus is easier for clinical implimentation. The patent is owned by Invitrogen which sells various laboratory and tissue culture reagents.
Method for modulating hemopoiesis
Patent Number: 6159940This patent seems ripe for development. It covers a composition of matter that appears, at face value, relatively easy to synthesize and is useful for the stimulation of hematopoietic stem cells.
Human neuronal attachment factor-1
Patent Number: 6759512This patent covers a protein called F-spondin that is involved in regulation of development and stem cell function. It is published that F-spondin induces differentiation of neural stem cells into neurons (Schubert D et al. F-spondin promotes nerve precursor differentiation. J Neurochem. 2006 Jan;96(2):444-53).
Embryonic germ cells, method for making same, and using the cells to produce a chimeric porcine
Patent Number: 6545199This patent teaches ways of culturing various pluripotent embryonic germ stem cells. Methods are disclosed, as well as specific culture reagents. In one particular embodiment emphasis is placed on embryonic germ cells from pigs.
Expansion of bone marrow stromal cells
Patent Number: 5962323This patent teaches how to grow bone marrow stromal cells in vitro. Several types of culture conditions for growing stromal cells are given. For example, the stromal cells may be expanded by treatment with FGF-1 on gelatin-coated plates. If FGF-1 can stimulate stromal cells in vitro, one wonders whether it also has similar in vivo...
Expansion of bone marrow stromal cells
Patent Number: 5766950This patent teaches that the clinically used cytokine FGF-1 is able to expand bone marrow stromal cells. This bone marrow stromal cell subtype seems to resemble, at least superficially, the mesenchymal stem cell. This is an interesting question that should be examined further.