Class: Expansion (424)
Use of GHRH-RP to stimulate stem cell factor production
Patent Number: 6159934This patent teaches that Sertoli cells make stem cell factor (which is interesting since people are co-culturing sertoli cells with islets from treating diabetes)...and that production of stem cell factor from sertoli cells may be upregulated by administration of the hormone GHRH-RP.
Method of suppressing differentiation by administering a human serrate-1 polypeptide
Patent Number: 7,179,622This patent covers composition of matter and use for polypeptides derived from Notch agonists. The particular Notch agonist is Serrate, which is involved in maintaining an undifferentiated state in stem cells. The invention is useful for expanding hematopoietic stem cells without inducing their differentiation. The inventors provided some evidence of CD34 self...
Ex vivo culture of stem cells
Patent Number: 5922597This patent teaches ways of increasing the number of stem cells ex vivo through a specific tissue culture cocktail that contains several cytokines but is serum-free and stromal cell-free.
Hemoregulatory compounds
Patent Number: 6114357This patent covers unique compositions of matter that stimulate the proliferation of hematopoietic stem cells.
Hemoregulatory compounds
Patent Number: 6054465Small molecule compounds are provided that stimulate hematopoietic stem cell proliferation. It would be interesting to see whether these compounds have selective stimulatory capability towards normal versus leukemic hematopoietic stem cells.
Methods for use of MPL ligands with primitive human stem cells
Patent Number: 7,416,887Thrombopoietin, otherwise known as the mpl ligand, is a potent stimulator of platelet production. Several companies are working on clinically implimenting this agent for patients with chemotherapy associated thrombocytopenia. For example, Ligand Pharmaceuticals has a patent on a thrombopoietic mimetic.
The current patent teaches how to used...
Methods for use of mpl ligands with primitive human stem cells
Patent Number: 6916470The mpl ligand, also known as thrombopoietin, is important for stimulation of platelet production from hematopoietic stem cells. Thrombopoietin, in addition to shifting differentiation towards the megakaryocytic lineage, also has some ability to induce proliferation of early hematopoietic stem cells. This patent uses the ability of thrombopoietin to stimulate stem cell proliferation in...
Methods for use of Mpl ligands with primitive human stem cells
Patent Number: 6326205Thrombopoietin (TPO) is a stimulatory molecule for early hematopoietic stem cells. In this patent the use of TPO and other ligands of its receptor, called mpl, are disclosed for purposes of expansion, and/or megakaryocytic differentiation of hematopoietic stem cells. It would be interesting to see if other types of stem cells also respond to mpl ligands in the...
Methods for use of Mpl ligands with primitive human hematopoietic stem cells
Patent Number: 6060052This patent teaches ways of using thrombopoietin or other ligands of MPL in order to stimulate proliferation of early hematopoietic stem cells. Since thrombopoietin is used in numerous stem cell expansion cocktails, this patent is very important.
Methods and compositions to improve germ cell and embryo survival and function
Patent Number: 6593309This patent provides methods of increasing viability of cells used for the generation of embryonic stem cells. The patent is also useful for in vitro fertilization, where viability of oocytes is an issue.