Class: Expansion (424)
Method for enhancing proliferation or differentiation of a cell using ob protein
Patent Number: 7074397This patent is useful for treatment of neutropenias and other conditions where expansion of bone marrow is required. The patent teaches the use of WSX ligands in stimulation of hematopoiesis. One such ligand is leptin. The patent has 2 independent claims. The first covers enhancing proliferation or differentiation a cell of the hematopoietic lineage through...
Composition comprising midkine or pleiotrophin protein and method of increasing hematopoietic cells
Patent Number: 6383480This patent covers a cytokine cocktail, that contains midkine, amongst other classical hematopoietic cytokines, useful for the expansion of hematopoietic stem cells. The cocktail may be used for the in vivo treatment of patients that are neutropenic or cytopenic, or may be used for the ex vivo expansion of hematopoietic stem cells.
Method of promoting hematopoiesis using derivatives of human chorionic gonadotropin
Patent Number: 5968513This patent teaches that the pregnancy associated protien hCG is a stimulator of hematopoiesis. This is an interesting concept since numerous cancers actually secrete hCG. I wonder if during pregnancy, or cancer, there is a high enough gradient of hCG to stimulate hematopoiesis. It is known that pregnant mice have an increase in spleen size, I wonder if the hCG has anything to do with...
Therapeutic and diagnostic methods and compositions based on Jagged/Notch proteins and nucleic acids
Patent Number: 6825007This patent covers composition of matter of Jagged 1, as well as its use in stem cell expansion. This patent is useful not only for classical regenerative applications, but also for stimulating production of special immune system cells.
Human hematopoietic-specific protein
Patent Number: 5945303This patent provides various pepties that stimulate proliferation of hematopoietic stem cells. It is not clear from the specification what exactly these peptides are stimulating in order to induce hematopoietic stem cell expansion.
Stimulator of stem cell division
Patent Number: 7,115,267This patent covers various hemaglobin beta chain derived sequences of peptides, as well as their use in combination with opioids for augmentation of hematopoiesis, as well as for antiviral and anticancer activities. The products claimed by the patent appear easy to generate and are potentially useful for other regenerative applications besides stimulation of hematopoiesis.
Inhibitor and stimulator of stem cell proliferation and uses thereof
Patent Number: 6784155The connection between the brain and the immune system is well-known, such as the experiments of Pavlovian conditioning of immune responses. Here the inventor covers the use of opiates and certain peptides for stimulation of bone marrow stem cell proliferation. Specific peptide sequences of hematopoietic stem cell stimulators are disclosed including peptide fractions of hemoglobin...
Inhibitor of stem cell proliferation and uses thereof
Patent Number: 5861483This patent describes peptides derived from hemoglobin that inhibit stem cell proliferation. These peptides are useful for protecting stem cells from killing by chemotherapy or radiation therapy.
Growth of pancreatic islet cells
Patent Number: 5681587This patent teaches how to expand islets as much as 1000 fold !! This is performed through culture of islet stem cells in laminin 5, and other substrates derived from cell lines that are provided in the patent. This patent may be useful to stem cell companies that are currently generating islets from of a variety of stem cell sources.
Laminin 5 for growth of pancreatic islet cells
Patent Number: 5672361This patent teaches that laminin-5 is very potent at stimulation of expansion of pancreatic islet cells from stem cells.