Class: Expansion (424)
Use of osteopontin for the treatment and/or prevention of neurologic diseases
Patent Number: 7,217,687Osteopontin, is a protein also called cytokine Eta-1, which contains Arg-Gly-Asp-Ser (RGDS) cell-binding sequences. Osteopontin is associated with cancer metastasis, as well as inflammatory immune cell migration, it interacts with alpha(v)beta1, alpha(v)beta3 and alpha(v)beta5 integrins and CD44 receptors. The current patent covers the use of osteopontin and...
Treatment for wounds
Patent Number: 7,262,174The use of epithelial cells (such as fibroblasts) transfected with telomerase for acceleration of wound healing is covered by this patent. This invention is conceptually attractive, however the possible effects of telomerase transfection in terms of immortalization of cells showed be consided. Since wounds already express inflammatory mediators such as free radicals (which damage
Method for expansion of epithelial stem cells
Patent Number: 7,347,876Corneal transplants are performed as a result of chemical or inflammatory injury to the clear part of the eye. Efficacy of corneal transplantation is decreased when the limbal stem cells which produce corneal epithelium are damaged or defective. Accordingly, transplantation of limbal stem cells has been performed clinically. A report in 1999 documented... ALS is a neurodegenerative motor disease for which no curative therapies exist. Additionally, little is known as to what even causes this condition. Although in familial ALS (accounts for 10% of cases) about 20% of patients have a mutation in the enzyme superoxide dismutase, the... This patent covers a method of growing neurons in a media that is free from serum and feeder cells. This media will be important in clinical trials since there are high regulatory hurdles if cells are used that are grown in the presence of xenogenic feeders or with serum containing media. This invention covers the newly discovered cytokine IL-20 and its use in stimulation of proliferation of early, but not differentiated hematopoietic progenitors. The patent is similar to a paper published by one of the authors (Liu L et al. 2003 Nov 1;102(9):3206-9.) The patent has 4 independent claims all directed to use of IL-20 and polypeptides derived from it. The first covers a method... This patent teaches the use of immunophilin binding agents for culturing of neuronal cells so as to use for cellular therapy. The patent has 2 independent claims, both covering a method of treatment of a neurodegenerative illness by administration of cells that have been cultured with immunophilin binding agents. This patent is very interesting, not from the perspective of cell therapy per... HEPP is a gene that appears to be found in certain stem cell populations involved in differentiation, although its function remains unclear. This patent is a composition of matter patent on the gene.
If there are some interesting properties found with this protein, it may be a really good patent to license since not too much work has been performed on it.
This patent is useful for treatment of proliferative diseases, including cancer. It is known that erythropoietin has functions on numerous stem cells in addition to hematopoietic ones. In this patent the inventors demonstrated that inhibition of EPO receptor signalling can have a useful anti-proliferative effect. The 2 independent claims cover use of the receptor... The invention is a composition of matter useful for treatment of bone defects and regeneration of bone. The composition is a porous ceramic material (beta.-tricalcium phosphate) of various pore sizes, porosity and granule size which is biocompatible with human tissue and supports the development of new bone throughout its structural form. The composition may be admixed with cells... 
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Use of VEGF and homologues to treat neuron disorders
Patent Number: 7,226,908
Serum-and steroid-free culture media for cerebellar granule neurons
Patent Number: 6506576
Use of LP82 to treat hematopoietic disorders
Patent Number: 7101539
Methods of using immunophilin binding drugs to improve integration and survival of neuronal cell transplants
Patent Number: 7041283
Hepp, a novel gene with a role in hematopoietic and neural development
Patent Number: 6872812
Preventives/remedies for proliferative organ diseases chronic arthritic diseases, hypertrophic scar or keloid
Patent Number: 7053050
Porous .beta.-tricalcium phosphate granules for regeneration of bone tissue
Patent Number: 6949251