Class: Expansion (424)
Transforming growth factor beta (TGF-.beta.) blocking agent-treated stem cell composition and method
Patent Number: 6841542This patent claims ex vivo inhibition of TGF beta in hematopoietic stem cells in order to increase speed of engraftment post recipient marrow ablation. Since TGF beta is an endogenous inhibitor of stem cell proliferation, the inhibition of the inhibitor should lead to enhanced proliferation. The technology described in this patent...
Culturing pancreatic stem cells having a specified, intermediate stage of development
Patent Number: 6759039This patent covers methods of culturing and expanding pancreatic stem cells. These cells may be used for the treatment of diabetes through encapsulation or administration into the liver such as thought by the Edmonton Protocol.
Methods for use of delivery composition for expanding, activating, committing or mobilizing one or more pluripotent, self-renewing and committed stem cells
Patent Number: 6649189This patent covers a method of administering a hematopoeitic stem cell activatory factor into a host using a depot-like formulation. One of the problems of protien administration into humans is that many proteins have a short half live and therefore the pharmacokinetic profiles may not be adequate for stimulation of the biological response needed. This patent seems to overcome this...
Retro-inverso peptides derived from interleukin-3
Patent Number: 7,115,571IL-3 is a potent expander of hematopoietic stem cells. Unfortunately administration of proteins is associated with poor pharmacokinetics and the need to develop special formulations that can systemically deliver the protein. This patent covers peptide derivatives of IL-3 which have improved activity and pharmacological activity compared to administration of the whole protein. This patent...
Peptides that stimulate cell survival and axon regeneration
Patent Number: 7,304,129This patent covers the composition of matter for several peptides as well as their utility for "stimulating the survival of, or neurite outgrowth in, cultured mammalian neuron, oligodendrocyte or fibroblast cells." The peptides are derived from the fibronectin domain of NCAM and have the ability to bind and activate the FGF2... This patent is useful for the manipulation of stem cell expansion through interfering with Neuregulin-4 signaling by antibody. Specifically, the patent has 2 independent claims that cover an antibody capable of binding to sequences which appear to be those of Neuregulin-4 or its active portions. This patent has one issued claim covering treatment of bone marrow cells with a compound (N-[4-[4-fluorophenyl)sulfonyl]phenyl]acetamide) and subsequent administration of the treated cells as a remedy for spinal cord injury.
This is a composition of matter patent on polypeptides homologous to insulin like growth factor binding protein (IGFBP). Various members of the IGFBP family, such as IGFBP-3, stimulate hematopoietic cell proliferation (Liu et al. Functional cloning of IGFBP-3 from human microvascular endothelial cells reveals its... This patent is important for entities seeking to use the hematopoietic stem cell stimulatory/differentiation factor, granulocyte colony stimulating factor (G-CSF) that is produced in E. coli. The patent has 2 independent claims, the first to a vector encoding human G-CSF, and the second to a method of producing human G-CSF. This is a composition of matter patent on compounds that modulate hedgehog signalling. Since hedgehog is important not only in stem cell proliferation, but also in cancer, this patent has uses both in regeneration and cancer control.
Growth factor which acts through erb b-4 rtk
Patent Number: 7094882
Compositions and methods for promoting tissue regeneration
Patent Number: 7,271,187
Methods of therapy and diagnosis using insulin-like growth factor binding protein-like polypeptides and polynucleotides
Patent Number: 7,109,030
Escherichia coli strain secreting human granulocyte colony stimulating factor (G-CSF)
Patent Number: 7070989
Small organic molecule regulators of cell proliferation
Patent Number: 7,115,653