Class: Expansion (424)
Method of making embryoid bodies from primate embryonic stem cells
Patent Number: 7,220,584This patent is an example of how a good patent strategy is executed. WARF has filed originally patents on the actual embryonic stem cells and their composition of matter. One of the best ways of differentiating cells from embryonic stem cells involves growing the embryonic stem cells as embryoid bodies, then subsequently digesting the embryoid body and collecting the...
Pancreatic islet cell growth factors
Patent Number: 6967100This patent teaches how to generate islet-like cells from fetal progenitors by culturing in the presence of one of the bone morphogenic proteins together with laminin or a laminin-like extracellular matrix. The patent has 3 independent claims all covering essentially the same process. The first one covers induction of growth and proliferation of "mammalian pancreatic epithelial cells into...
Stem cell growth factor-like polypeptide
Patent Number: 6667391This patent provides peptides and various compositions of matter that are useful for stimulation of stem cell proliferation. It is unclear what the biological analogues of these peptides are, but they seem very useful for anyone seeking to enter the area of stem cell therapeutics.
Use of .beta.-catenin in the expansion of stem and progenitor cells
Patent Number: 6465249The various signalling pathways associated with embryogenesis seem to be fundamentally important in controlling a variety of stem cells. In this patent the manipulation of beta catenin signalling is covered for the activation of stem cells to either differentiate or proliferate.
Medium for growing human embryonic stem cells
Patent Number: 7,297,539One of the restrictions of tissue culture in general has been the need for fetal calf serum. No one has yet figured out what is the "magical mixture" of proteins and growth factors that allows fetal calf serum its properties to all for such effective growth of cells outside of the body. In fact, some other groups use horse serum, or
Conditioned media for propagating human pluripotent stem cells
Patent Number: 6642048This patent is part of Geron's armamentarium of patents covering not only embryonic stem cells (licensed from WARF), but also ways of growing them in absence of undefined materials. In this particular patent feeder-free culture methods for maintaining embryonic stem cells, as well as "pluripotent stem cells" are covered.
Medium for growing human embryonic stem cells
Patent Number: 7,455,983One of the issues of embryonic stem cell therapeutics development is the relative lack of methods for expanding them without inducing their differentiation. Various methodologies are known in the art, for example use of different feeder layers or speciality media.
The current patent is very...
Method of inducing neuronal production in the brain and spinal cord
Patent Number: 7037493This patent has 2 independent claims. The first covers a method of addition of medium spiny neurons in an adult brain through local lateral wall administration of a nucleotide expressing BDNF, as well as noggin. The second independent claim covers generation of medium spiny neurons in a patient with Huntington's disease. Medium spiny neurons are inhibitory neurons...
Methods and compositions for producing artificial fascia
Patent Number: 6482645The fascia is a layer of connective tissue that surrounds muscles, bones, and joints. This patent teaches ways of generating artificial fascia's through the use of various stem cells and biological matrices.
Cell culture medium containing growth factors and L-glutamine
Patent Number: 6838284This is a patent for a specific type of tissue culture media that may be used for growth and expansion of various stem cells.
The media contains combinations of various factors such as anti-oxidants, nutrients, and growth factors.
This patent may be useful not only for laboratory reagents but as a basis for developing cellular therapy media for ex vivo expansion in a