Class: Differentiation (190)
Antisense oligonucleotides to type I procollagen
Patent Number: 7,173,122One of the potential problems with stem cell therapy is the propensity of certain cell types to contribute to scar formation. For example, during embryonic healing, scars are not formed on injured tissues, however, adult injured tissue is prone to scarring. Formation of scars is especially relevant in the post-myocardial infarct situation in which the non-functional scar tissue replaces...
Methods to stimulate insulin production by pancreatic beta-cells
Patent Number: 6903073Hedgehog proteins are involved in development and other biological functions through activation of their receptor called "patched". Hedgehog signalling is inhibited by cyclopamine. Since the authors of the patent originally found that inhibiting hedgehog signalling reduces insulin production, and transfection with hedgehog increases insulin production, (Thomas
Hematopoietic differentiation of human embryonic stem cells
Patent Number: 6613568This patent teaches the generation of human hematopoietic stem cells from human embryonic stem cells by the simple culture of the embryonic stem cells on human bone amrrow stromal cells.
Cultures of GFAP+ nestin+ cells that differentiate to neurons
Patent Number: 6878543Generation and expansion of neuronal cells is described in this patent through inducting proliferation of GFAP+, nestin+ stem cells of neuronal origin through treatment with EGF, amphiregulin, aFGF, bFGF, TGF.alpha. and then inducing differentiation through serum free culture. The cells generated by this means...
Methods for transdifferentiation of body tissues
Patent Number: 6670397This patent has some pretty broad claims. It teaches to repair tissue by inducing de-differentiation of cells, and then stimulating redifferentiation into another histological cell type. This patent may be very strong ammunition against companies active in the area of stem cell therapy that have not licensed it.
Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
Patent Number: 6555374This patent seems to cover a composition of cells that is made of adipose tissue and hematopoietic tissue. The composition is useful for regeneration of a hematopoietic system after ablation. Additionally, this composition may have uses for the induction of angiogenesis. In some papers, the induction of angiogenesis by bone marrow stem cells requires large amounts of stem cells to be...
Compositions, kits, and methods for modulating survival and differentiation of multi-potential hematopoietic progenitor cells
Patent Number: 6261841This patent teaches that administration of prolactin may be used for enhancing hematopoiesis. This is interesting since there are other patents, including by Stem Cell Therapeutics, that teach the use of prolactin and other compounds for stimulation of neural stem cells.
Methods of making pancreatic islet cells
Patent Number: 6815203This patent teaches ways of dedifferentiating pancreatic duct or exocrine cells and then redifferentiating the cells to generate functional islet cells. This patent is especially relevant in light of the Edmonton Protocol that provides methods of transplanting allogeneic pancreatic islets. The problem with the Edmonton Protocol is that it takes up to 2, sometimes even more pancreas's for 1...
Production of pancreatic islet cells and delivery of insulin
Patent Number: 6967019This patent teaches ways of making gastrointestinal organ cells and pancreatic cells express insulin in vitro, conceptually for introduction in vivo. The patent essentially teaches that introduction of a neuroendocrine class B basic helix-loop-helix (bHLH) transcription factor gene or the neurogenin3 (Ngn3) gene into gastrointestinal organ cells or pancreatic cells, respectively, endows...
Versican and epithelial-mesenchymal interaction
Patent Number: 7,163,679Versican is a chondroitin sulfate proteoglycan that is considered part of the extracellular matrix. Various isoforms of Versican exist, some associated with specific stages of development. In this patent the inventors found that versican-expressing dermal papilla (DP) cells have the ability to induce hair generation. Accordingly, the patent aims at screening agents that may be used to induce...