Class: Differentiation (190)
Methods of controlling proliferation and differentiation of stem and progenitor cells
Patent Number: 6962698This patent essentially teaches that reducing the copper content in a hematopoietic culture increases efficiency of the culture. The patent has 2 independent claims, the first covering "A method of transplanting expanded undifferentiated hematopoietic cells " and the second covering "A method of adoptive immunotherapy ". The idea that reducing copper content expands ability of...
Method of inducing fetal hemoglobin synthesis
Patent Number: 6936254This patent covers induction of fetal hemoglobin gene expression by treatment of cells with specific polypeptides. The utility of inducing fetal hemoglobin is for diseases in which adult hemoglobin is defective in carrying oxygen. This invention is useful for the treatment of diseases like sickle cell anemia. The patent has 2 independent claims that essentially cover: a) Induction of adult...
Methods of creating constructs useful for introducing sequences into embryonic stem cells
Patent Number: 6942995This invention relates to the generation of knock-out animals Through genetically ablating a specific gene sequence in embryonic stem cells of an animal, it is possible to develop animals, called"knock-outs" which lack the specific sequences throughout all cells of the body. The patent has two independent claims directed towards unique gene-targeting constructs that through homologous...
Hypoxia-mediated neurogenesis assay
Patent Number: 6924142This patent teaches the induction of differentiation of neural stem cells, the use of hypoxia for enhancing function, and the subsequent use of the cells obtained for drug screening. The patent has one independent claim that covers: A method for screening the effects of drugs or other agents on neuronal cells, comprising: a) preparing a cell culture comprising a cell population enriched...
Erythropoietin-mediated neurogenesis
Patent Number: 6165783EPO is used clinically for treatment of anemia and is considered generally safe. This patent teaches that administration of EPO can stimulate the differentiation of neurons. Currently this concept is being tested (at least in part) by Stem Cell Therapeutics who are conducting clinical trials using EPO together...
Generation of hematopoietic cells from multipotent neural stem cells
Patent Number: 7,204,979The concept of cellular transdifferentiation has come under much attack in the last few years. For example, some authors believe that transdifferentiation can be explained by cellular fusion in in vivo systems, and by non-physiological, contrived, in vitro systems. This patent covers the generation of hematopoietic stem cells from multipotent neural stem cells by the administration of the...
Generation of hematopoietic cells from multipotent neural stem cells
Patent Number: 6093531Brain to blood...thats essentially what this patent teaches...the use of neural stem cells as a source of hematopoietic cells.
Ligands that modulate differentiation of mesenchymal stem cells
Patent Number: 6379953This patent teaches the use of the molecule ALCAM for induction of mesenchymal cell differentiation. It is also thought in this patent that ALCAM may be useful for the isolation of certain types of mesenchymal stem cells.
Ligands that modulate differentiation of mesenchymal stem cells
Patent Number: 6022540This patent covers the induction of mesenchymal stem cell differentiation by activation of a ligand called ALCAM. Mesenchymal stem cells can differentiate into a wide variety of non-hematopoietic tissues and are useful for many clinical applications since they can be transplanted across allogeneic barriers, therefore knowing how to modulate their differentiation...
Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
Patent Number: 7,144,997This patent covers the use of hedgehog proteins and various analogues for maintaining neuron and neuronal stem cell viability. The claims cover specific compositions of matter, whereas the specification teaches various means of using the compositions of matter for protecting dopaminergic neurons from cell death.
The basis of this patent is described in another