Class: Differentiation (190)
Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices
Patent Number: 6548299This patent teaches how to generate cells of the lymphoid lineage in vitro through a variety of devices and culture techniques. This patent could be used for generating T suppressor cells in order to antigen-specifically inhibit autoimmunity.
Hematopoietic differentiation of human pluripotent embryonic stem cells
Patent Number: 6280718This patent covers ways of inducing the generation of hematopoietic stem cells from embryonic stem cells. This is very useful since it may be possible to generate allogeneic hematopoietic stem cells for the whole population using such a method.
Method for producing dendritic cells
Patent Number: 7,247,480Dendritic cells are one of the most important cells of the immune system, having the unique ability to stimulate naive T cells. Additionally, under specific conditions, dendritic cells can give rise to T regulatory cells and dampen immune responses. The current patent teaches ways of generating dendritic cells from embryonic stem cells by culturing embryoid bodies with IL-3 and/or...
Human growth differentiation factor encoding sequence and polypeptide encoded by such DNA sequence and producing method thereof
Patent Number: 6656708This patent provides a novel protein that is capable of stimulating stem cell proliferation and differentiation. The protein is called human growth differentiation factor (hGDF3-2). This patent is useful for generation of novel stem cell activating therapeutics. Additionally, it may be used to generate competition to the currently used stem cell stimulatory cytokines.
Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cells
Patent Number: 6255112This patent covers the use of mesenchymal stem cells to stimulate hematopoietic stem cells. Mesenchymal stem cells are actually in Phase III trials for prevention of graft versus host after hematopoietic stem cell transplants. This patent ensures that if the mesenchymal stem cells also stimulate hematopoiesis, then Osiris is covered from an IP perspective.
Phosphatidylinositol 3-kinase inhibitors as stimulators of endocrine differentiation
Patent Number: 6413773This patent teaches that if one inhibits the PI3 kinase pathway, it is possible to induce differentiation of pancreatic stem cells into islet-like cells. PI3k has activity in a variety of stem cells, including hematopoietic stem cells. It will be interesting to see what modification of this enzyme does in other types of stem cells.
Production of megakaryocytes by the use of human mesenchymal stem cells
Patent Number: 7,153,500This patent covers a method of increasing megakaryocytes (precursors of platelets) to patients that are deficient in these cells. Specifically, there are two claims to the patent. The first covers the increasing of megakarocyte numbers by administration of mesenchymal stem cells. The second covers a method of increasing megakaryocyte numbers through administration of
Production of megakaryocytes by the use of human mesenchymal stem cells
Patent Number: 6225119This patent teaches that mesenchymal stem cells can be used to support the production of platelets from hematopoietic stem cells. Additionally, the patent covers genetically transformed hematopoietic stem cells in contact with mesenchymal stem cells for the generation of genetically transformed platelets.
Method and device for regenerating cartilage in articulating
Patent Number: 6056777This patent provides medical devices useful for the treatment of cartilage injury. Stem cells may be differentiated into cartilage and used in combination with this invention.
Methods of controlling proliferation and differentiation of stem and progenitor cells
Patent Number: 7,312,078Homing of hematopoietic stem cells to their endosteal niche in the bone marrow is dependent in part on expression of the calcium sensing receptor. Since various chelating agents are known to modify calcium levels systemically, one interesting question is whether such chelating agents can be used to modulate stem cell expansion or differentiation ability. The...