Class: Differentiation (190)

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Method of inducing formation of kidney epithelia from mesenchymal precursors

Patent Number: 7022666

This patent seems to cover the preservation of a kidney, despite its title. It may be that preservation is achieved through endogenous stem cell differentiation of kidney epithelium. The patent has one claim covering a method of preserving a kidney by contacting the kidney with a ligand for gp130 receptor (ie LIF, a cardiotrophin, a ciliary neuronotrophic factor...

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Method of inducing formation of kidney epithelia from mesenchymal precursors

Patent Number: 6423681

This patent teaches how to induce formation of new kidney cells in vivo through the administration of ligands of gp130 such as LIF. This is one of the few patents that covers administration of therapies systemically that induce generation of new cells by stimulation of endogenous stem cells. This patent is in line with the approach of Transition Therapeutics...

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Polypeptides that induce cell proliferation or induce fetal hemoglobin

Patent Number: 7,241,862

This patent covers several amino acid and nucleotide sequences which are useful for modificatin of cellular differentiation and expansion. The claims refer to several sequence IDs, whereas the specification describes what appears to be numerous disjointed compositions of matter, uses, and formulations. For example, the patent specification talks about cadherins, then IL-17, then...

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Platform for the differentiation of cells

Patent Number: 6638765

This patent covers methods of dedifferentiating cells, and redifferentiating them in order to produce islet-like cells for the treatment of diabetes.

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Transdiffentiation of transfected epidermal basal cells into neural progenitor cells, neuronal cells and/or glial cells

Patent Number: 7041507

This invention teaches how to generate neurons from skin. Essentially, the inventors found that through the process of isolating epidermal stem cells (basal cells), transfected said basal cells with genes encoding neurogenic transcription factors, suppressing transcription factors that maintain a differentiated phenotype (by for example antisense), and then culturing the cells with exogenous...

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Transdifferentiation of epidermal basal cells into neural progenitor cells, neuronal cells and/or glial cells

Patent Number: 6949380

This invention is similar to patent 7041507, which was filed by the same inventors. The current invention teaches generation of neuronal-like cells through the transdifferentiation of epidermal basal cells. The invention has 3 independent claims covering, "An in vitro method of transdifferentiating an epidermal basal cell ", "A kit for transdifferentiating, in vitro, an epidermal...

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Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells

Patent Number: 6087168

This patent teaches how to induce "trandifferentiation" of epidermal cells into neurons. The neurons are useful for treatment of neurodegenerative diseases.

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Method of genetically modifying very primitive quiescent human hematopoietic stem cells

Patent Number: 6919209

Gene therapy is limited by ability to transfect quiescent cells. Since the very primitive hematopoietic stem cells reside in a quiescent state, it is difficult to transfect them. This patent demonstrates transfection of early hematopoietic stem cells using an adeno-associated vector. The patent has one independent claim that covers: A method for stably transferring Inventors: Chatterjee, Saswati (Sierra Madre, CA); Wong, Jr., Kamehameha K. (Sierra Madre, CA); Wong, Christie (Pasadena, CA); Fisher-Adams, Grace (La Canada, CA)

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