Patents
Reversible gelling culture media for in-vitro cell culture in three-dimensional matrices
Patent Number: 6103528This patent teaches how to make a tissue culture media which gells upon treatment or exposure to specific conditions. The advantage of this is that cells can be added when the media is liquid, and then the gelling characteristic can be used for the formation of specially shaped structures, structures which can subsequently be implanted.
Inventors: An, Yuehuei H. (Charleston, SC); Mironov, Vladimir A. (Mt. Pleasant, SC); Gutowska, Anna (Richland, WA)
Assignee: Battelle Memorial Institute (Richland, WA); Medical University of South Carolina (Charleston, SC)
Date of First Priority Issue: Friday April 17th, 1998
Human marrow stromal cell lines which sustain hematopoiesis
Patent Number: 6103522Culture of early hematopoietic stem cells (human ones) was previously performed on murine stromal cells, and stromal cells of mouse that are transfected with certain genes. In this patent a human stromal cell line is provided (can be bought at ATCC), which is capable of sustaining expansion of early human hematopoietic stem cells. This cell line allows for growth and generation of human...
Inventors: Torok-Storb, Beverly (Seattle, WA); Roecklein, Bryan A. (Seattle, WA); Johnson, Gretchen (Issaquah, WA)
Assignee: Fred Hutchinson Cancer Research Center (Seattle, WA)
Date of First Priority Issue: Wednesday July 20th, 1994
Universal donor cells
Patent Number: 6100443This patent covers non-human cells and stem cells that are "de-immunogenized" so that they may be transplanted into humans without rejection. The patent "de-immunogenizes" the cells by inducing expression of human anticomplement proteins, as well as by suppressing the expression of immunogenic proteins such as those of the MHC type.
Inventors: Sims, Peter J. (Mequon, WI); Bothwell, Alfred L. M. (Guilford, CT); Elliot, Eileen A. (New Haven, CT); Flavell, Richard A. (Killingworth, CT); Madri, Joseph (North Branford, CT); Rollins, Scott (Monroe, CT); Bell, Leonard (Woodbridge, CT); Squinto, Stephe
Assignee: Oklahoma Medical Research Foundation (Oklahoma City, OK); Yale University (New Haven, CT)
Date of First Priority Issue: Monday June 12th, 1989
G-CSF receptor agonists
Patent Number: 6100070This patent covers the composition of matter of several polypeptides and compounds that can activate the granulocyte colony stimulating factor receptor. These compounds can be developed into therapeutic agents for similar indications such those treated by Amgen's Neupogen.
Inventors: Zurfluh, Linda L. (Kirkwood, MO); Klein, Barbara K. (St. Louis, MO); McWherrter, Charles A. (Wildwood, MO); Feng, Yiqing (St. Louis, MO); McKearn, John P. (Glencoe, MO); Braford-Goldberg, Sarah Ruth (St. Louis, MO)
Assignee: G. D. Searle & Co. (Chicago, IL)
Date of First Priority Issue: Thursday October 5th, 1995
Differentiation of granulocytic and monocytic progenitor cells
Patent Number: 6096540This patent teaches various proteins that can be used as discriminatory markers for distinguishing progenitors of the monocytic lineage from progenitors of the granulocytic lineages.
Inventors: Olweus, Johanna (Palo Alto, CA); Lund-Johansen, Fridtjof (Palo Alto, CA); Thompson, Peter (Danville, CA)
Assignee: Becton Dickinson and Company (Franklin Lakes, NJ)
Date of First Priority Issue: Monday September 30th, 1996
Generation of hematopoietic cells from multipotent neural stem cells
Patent Number: 6093531Brain to blood...thats essentially what this patent teaches...the use of neural stem cells as a source of hematopoietic cells.
Inventors: Bjornson, Christopher R. (Seattle, WA); Rietze, Rod L. (Brunswick, AU); Reynolds, Brent A. (Saltspring, CA); Vescovi, Angelo L. (Milan, IT)
Assignee: NeuroSpheres Holdings Ltd. (Calgary, CA)
Date of First Priority Issue: Monday September 29th, 1997
Co-administration of interleukin-3 mutant polypeptides with CSF's for multi-lineage hematopoietic cell production
Patent Number: 6093395This patent teaches various forms of IL-3 together with various stem cell stimulatory factors for the expansion of hematopoietic stem cells.
Inventors: Bauer, S. Christopher (New Haven, MO); Abrams, Mark Allen (St. Louis, MO); Braford-Goldberg, Sarah Ruth (St. Louis, MO); Caparon, Maire Helena (Chesterfield, MO); Easton, Alan Michael (Maryland Heights, MO); Klein, Barbara Kure (St. Louis, MO); McKearn, J
Assignee: G. D. Searle & Co. (Chicago, IL)
Date of First Priority Issue: Tuesday November 24th, 1992
Methods for promoting functional regeneration of mammalian muscle by administering leukaemia inhibitor factor
Patent Number: 6093390This patent teaches that LIF may be used alone, or in combination with neurotrophic factors for the stimulation of neurogenesis and muscle innervation. This patent may be useful for combining with exogenous stem cell sources such as cord blood. Additionally, the patent may be used for treating patients with multiple sclerosis.
Inventors: Bartlett, Perry (North Carlton, AU); Murphy, Mark (Fitzroy, AU); Brown, Melissa (London, GB)
Assignee: Amrad Corporation Limited (Victoria, AU)
Date of First Priority Issue: Tuesday March 20th, 1990
Hemoglobin alpha and beta chain peptide fragments useful for inhibiting stem cell proliferation
Patent Number: 6090782This patent covers peptides that inhibit proliferation of hematopoietic stem cells. These peptides may be used for protection form chemotherapy or radiotherapy induced stem cell destruction.
Inventors: Tsyrlova, Irena (Gaithersburg, MD); Wolpe, Stephen D. (Rockville, MD)
Assignee: Pro-Neuron, Inc. (Gaithersburg, MD)
Date of First Priority Issue: Wednesday March 31st, 1993
Method of increasing the relative number of CD34.sup.+ cells in a cell population
Patent Number: 6090625This patent teaches that by crosslinking various portions of MHC II on differentiated cells, the cells will dedifferentiate and increase the number of CD34 stem cells. This patent, if the data is reproducible, could revolutionize stem cell therapy. The company currently developing this patent is called TriStem.
Inventor: Abuljadayel, Ilham (London, GB)
Assignee: Dhoot, Ghazi Jaswinder (London, GB)
Date of First Priority Issue: Thursday February 2nd, 1995