Patents
Electrospraying apparatus and method for introducing material into cells
Patent Number: 6093557This patent teaches methods of introducing materials into cells. It is useful for introducing genes into cells to cause differentiation, or alternatively introducing cytoplasm of embryonic stem cells into adult cells in order to "rejuvenate" them.
Inventors: Pui, David Y. H. (Plymouth, MN); Chen, Da-Ren (Lauderdale, MN)
Assignee: Regents of the University of Minnesota (Minneapolis, MN)
Date of First Priority Issue: Thursday June 12th, 1997
Human embryonic pluripotent germ cells
Patent Number: 6090622This patent teaches a new type of stem cell that is isolated from the gonadal ridge.
Inventors: Gearhart, John D. (Baltimore, MD); Shamblott, Michael Joseph (Baltimore, MD)
Assignee: The Johns Hopkins School of Medicine (Baltimore, MD)
Date of First Priority Issue: Monday March 31st, 1997
Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells
Patent Number: 6087168This patent teaches how to induce "trandifferentiation" of epidermal cells into neurons. The neurons are useful for treatment of neurodegenerative diseases.
Inventors: Levesque, Michel F. (Beverly Hills, CA); Neuman, Toomas (Santa Monica, CA)
Assignee: Cedars Sinai Medical Center (Los Angeles, CA)
Date of First Priority Issue: Wednesday January 20th, 1999
Monoclonal antibodies for human mesenchymal stem cells
Patent Number: 6087113As part of Osiris's territorial stake on the mesenchymal stem cell area, this patent covers antibodies that are publically available from ATCC, that specifically recognize mesenchymal stem cells.
Inventors: Caplan, Arnold I. (Cleveland Heights, OH); Haynesworth, Stephen E. (Cleveland Heights, OH)
Assignee: Case Western Reserve University (Cleveland, OH)
Date of First Priority Issue: Tuesday June 18th, 1991
Composition and method for preserving progenitor cells
Patent Number: 6084060This patent discloses lectins and portions of the lectins that are capable of protecting various types of stem cells from death or inactivation.
Inventor: Moore, Jeffrey G. (New York, NY)
Assignee: ImClone Systems Incorporated (New York, NY)
Date of First Priority Issue: Monday December 9th, 1996
Method of preparing hematopoietic stem cells with gp105-specific antibodies
Patent Number: 6083747This patent discloses a new marker of hematopoietic stem cells. The marker can be used for isolation, purification, or identification of such stem cells.
Inventors: Wong, Peter M. C. (Gladwyne, PA); Chung, Siu-Wah (Gladwyne, PA); Han, Xiaodong (San Francisco, CA)
Assignee: Stemcell Therapeutics LLC (Bala Cynwyd, PA)
Date of First Priority Issue: Tuesday June 6th, 1995
Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products
Patent Number: 6083523This patent covers a device that is implantable, and explantable, that can be used for administration of stem cells so that they will not be rejected by the host immune system. It will be interesting to use such devices with embryonic stem cells so as to allow the embryonic stem cells to secrete soluble factors in vivo that hopefully will possess rejuvenating ability.
Inventors: Dionne, Keith E. (Rehoboth, MA); Emerich, Dwaine F. (Providence, RI); Hoffman, Diane (Cambridge, MA); Sanberg, Paul R. (Spring Hill, FL); Christenson, Lisa (New Haven, CT); Hegre, Orion D. (Green Valley, AZ); Scharp, David W. (St. Louis, MO); Lacy, Paul E
Assignee: Brown University Research Foundation (Providence, RI); Brown University (Providence, RI)
Date of First Priority Issue: Thursday April 25th, 1991
Pluripotential bone marrow cell line and methods of using the same
Patent Number: 6082364This patent seems to cover a cell that is very similar to the cell covered by Osiris...that is mesenchymal stem cells.
Inventors: Balian, Gary (Charlottesville, VA); Wang, Gwo-Jaw (Charlottesville, VA); Diduch, David (Charlottesville, VA); Hahn, Chang (Charlottesville, VA)
Assignee: Musculoskeletal Development Enterprises, LLC (Charlottesville, VA)
Date of First Priority Issue: Monday December 15th, 1997
Culture vessel for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using same
Patent Number: 6080581This patent covers a method of generating three dimensional tissues in culture. The culture system allows for continuous addition of media and growth factors as well as escape of waste products.
Inventors: Anderson, Charles Daniel (Houston, TX); Dodd, Charlie W. (Seabrook, TX)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday July 2nd, 1998
Genetic engineering of cells to enhance healing and tissue regeneration
Patent Number: 6077987This patent covers the induction of healing through administration of mesenchymal stem cells alone, or mesenchymal stem cells after transfection with other genes.
Inventors: Breitbart, Arnold S. (Great Neck, NY); Grande, Daniel S. (Sea Cliff, NY); Mason, James M. (Bethpage, NY)
Assignee: North Shore-Long Island Jewish Research Institute (Manhasset, NY)
Date of First Priority Issue: Thursday September 4th, 1997