Patents
Hemoregulatory compounds
Patent Number: 6077857This patent provides compositions of matter that stimulate hematopoietic stem cell proliferation. These compounds appear to be small molecules and have an acceptable safety profile in the data provided.
Inventors: Bhatnagar, Pradip Kumar (Exton, PA); Heerding, Dirk Andries (Malvern, PA)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Date of First Priority Issue: Tuesday November 12th, 1996
Parthenogenic oocyte activation
Patent Number: 6077710This patent covers the generation of embryos through virgin birth or parthenogenesis. Essentially if an oocyte is activated through the induction of calcium flux it can generate an embryo-like structure which can be used to derive stem cells.
Inventors: Susko-Parrish, Joan L. (Monona, WI); Northey, David L. (Madison, WI); Leibfried-Rutledge, M. Lorraine (Madison, WI); Stice, Steven L. (DeForest, WI)
Assignee: Infigen, Inc. (Deforest, WI)
Date of First Priority Issue: Wednesday February 10th, 1993
Method of determining progenitor cell content of a hematopoietic cell culture
Patent Number: 6077708This patent teaches how to determine the number of stem cells in a tissue culture situation through assessing various metabolic properties of the tissue culture media.
Inventors: Collins, Paul C. (Bridgewater, NJ); Papoutsakis, E. Terry (Glenview, IL); Miller, William M. (Evanston, IL)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday July 18th, 1997
Hapatoblasts and method of isolating same
Patent Number: 6069005This patent discloses methods of purifying hepatic stem cells. These stem cells may be expanded and used for therapeutic purposes. One interesting application of this invention would be to tranfect embryonic stem cell cytoplasm into these hepatocyte stem cells and to see if we can increase their expansion capability. Theoretically hepatocytes should be easier to tranplant than other tissues...
Inventors: Reid, Lola M. (Chapel Hill, NC); Sigal, Samuel H. (Riverdale, NY); Brill, Shlomo (Ramat-Gan, IL); Holst, Patricia A. (Ossining, NY)
Assignee: Albert Einstein College of Medicine of Yeshwa University (Bronx, NY)
Date of First Priority Issue: Saturday September 7th, 1991
Cell compositions for use in transplantation
Patent Number: 6068836This patent teaches how to transfect quiescent hematopoietic stem cells. Transfection of these primitive stem cells should be useful for a variety of gene therapy applications including treatment of several metabolic diseases such as Krabbe Disease.
Inventor: Quesenberry, Peter J. (Shrewsbury, MA)
Assignee: University of Massachusetts (Boston, MA)
Date of First Priority Issue: Wednesday November 23rd, 1994
Neural cell protein marker RR/B and DNA encoding the same
Patent Number: 6066451This patent provides a marker for the identification of specific neural cells. This marker is useful for knowing the quantity and quality of neurons generated from various stem cell populations.
Inventors: Avraham, Shalom (Brookline, MA); Avraham, Hava (Brookline, MA); Groopman, Jerome E. (Brookline, MA)
Assignee: Beth Israel Deaconess Medical Center, Inc. (Boston, MA)
Date of First Priority Issue: Monday October 3rd, 1994
Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
Patent Number: 6066318This patent covers variants of thrombopoietin and the use of these variants in combination with other hematopoietic cytokines for the stimulation of hematopoietic stem cells.
Inventors: Feng, Yiqing (St. Louis, MO); Staten, Nicholas R. (St. Louis, MO); Baum, Charles M. (Evanston, IL); Summers, Neena L. (St. Charles, MO); Caparon, Maire Helena (Chesterfield, MO); Bauer, S. Christopher (New Haven, MO); Zurfluh, Linda L. (Kirkwood, MO); McK
Assignee: G.D. Searle & Co. (Chicago, IL)
Date of First Priority Issue: Thursday October 5th, 1995
Method of using IL-11 for treating deficiencies in hematopoietic progenitor or stem cells
Patent Number: 6066317This patent teaches that interleukin 11 can be administered into patients for stimulation of hematopoietic activity. Interleukin 11 is known to upregulate platelet production but not as potently as TPO.
Inventors: Yang, Yu-Chung (Indianapolis, IN); Bennett, Frances K. (Melrose, MA); Paul, Stephan R. (Wyncote, PA)
Assignee: Genetics Institute, Inc. (Cambridge, MA)
Date of First Priority Issue: Wednesday November 22nd, 1989
TGF.beta.1 responsive bone marrow derived cells to express a recombinant protein
Patent Number: 6063593This patent teaches that tranforming growth factor beta treatment of hematopoietic stem cells will make them more susceptible to gene transfection.
Inventors: Gordon, Erlinda Maria (Glendale, CA); Hall, Frederick L. (Glendale, CA); Anderson, W. French (San Marino, CA)
Assignee: University of Southern California University Park Campus (Los Angeles, CA)
Date of First Priority Issue: Tuesday November 12th, 1996
Methods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules
Patent Number: 6060270This patent teaches how to grow kidney tubules from renal stem cells, and how to use these for making a hollow fiber filter that resembles an artificial kidney.
Inventor: Humes, H. David (Ann Arbor, MI)
Assignee: The University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Monday March 2nd, 1992