Patents
Method for testing the differentiation status in pancreatic cells of a mammal
Patent Number: 5948623This patent covers the use of the transcription factor Pax4 for identifying the number of pancreatic stem cells in an animal. This patent is useful for entities seeking to expand the number of pancreatic stem cells in vivo through administration of various compounds. One such example is the work by Transition Therapeutics utilizing gastrin with EGF for treatment of diabetes through inducing...
Inventors: Sosa-Pineda, Beatriz (Memphis, TN); Gruss, Peter (Gottingen, DE)
Assignee: Max-Planck Gesellschaft Zur Forderung der Wissenschaften E.V. (Berlin, DE)
Date of First Priority Issue: Tuesday December 31st, 1996
Method and article to induce hematopoietic expansion
Patent Number: 5948426This patent covers a matrix derived from bone that is able to induce the proliferation and expansion of hematopoietic stem cells in vitro.
Inventor: Jefferies, Steven R. (York, PA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Saturday May 3rd, 1997
Method for culturing CD34.sup.+ cells in a serum-free medium
Patent Number: 5945337This patent covers the composition of matter for several types of tissue culture media that are useful for ex vivo expanding stem cells in absence of various forms of serum. This is useful for clinical purposes since administration of cells grown in serum is not looked upon favorably by regulatory agencies.
Inventor: Brown, Ronald L. (Derwood, MD)
Assignee: Quality Biological, Inc. (Gaithersburg, MD)
Date of First Priority Issue: Friday October 18th, 1996
Human hematopoietic-specific protein
Patent Number: 5945303This patent provides various pepties that stimulate proliferation of hematopoietic stem cells. It is not clear from the specification what exactly these peptides are stimulating in order to induce hematopoietic stem cell expansion.
Inventors: Wei, Ying-Fei (Darnestown, MD); Li, Haodong (Gaithersburg, MD)
Assignee: Human Genome Sciences, Inc. (Rockville, MD)
Date of First Priority Issue: Thursday April 11th, 1996
Lineage-directed induction of human mesenchymal stem cell differentiation
Patent Number: 5942225Disclosed are tissue culture conditions that can direct the differentiation of mesenchymal stem cells into the following cell lineages: osteogenic, chondrogenic, tendonogenic, ligamentogenic, myogenic, marrow stromagenic, adipogenic and dermogenic. This patent is useful for the generation of artificial tissue. Although the mesenchymal stem cells themselves are poorly immunogenic, the tissue...
Inventors: Bruder, Scott P. (Owings Mills, MD); Caplan, Arnold I. (Cleveland Heights, OH); Haynesworth, Stephen E. (Cleveland Heights, OH)
Assignee: Case Western Reserve University (Cleveland, OH); Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Tuesday January 24th, 1995
Recombinant primate granulocyte macrophage-colony stimulating factor
Patent Number: 5942221This patent covers primate G-CSF. G-CSF is a potent stimulator of granulocyte production and is used clinically under the name Neupogen and more recently Neulasta.
Inventors: Clark, Steven C. (Winchester, MA); Kaufman, Randal J. (Boston, MA); Wong, Gordon G. (Cambridge, MA)
Assignee: Novartis Corporation (Basel, CH)
Date of First Priority Issue: Wednesday July 6th, 1994
Methods and kits for stimulating production of megakaryocytes and thrombocytes
Patent Number: 5939529This patent covers the use of various types of C Reactive Protein mutants for the stimulation of platelet production. CRP is actually made naturally by the liver in times of inflammation. I wonder if natural CRP also has hematopoietic effects?
Inventor: Potempa, Lawrence A. (Deerfield, IL)
Assignee: Immtech International Inc. (Evanston, IL)
Date of First Priority Issue: Wednesday February 23rd, 1994
Mammalian multipotent neural stem cells
Patent Number: 5928947This patent covers a type of stem cell that gives rise to numerous neural lineages. The stem cell is useful for administration after differentiation, administration in an undifferentiated state, as well as administration after gene transfection. This stem cell is purified from the fetal neural crest.
Inventors: Anderson, David J. (Altadena, CA); Stemple, Derek L. (Newton, MA)
Assignee: California Institute of Technology (Pasadena, CA)
Date of First Priority Issue: Monday July 27th, 1992
Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage
Patent Number: 5928945This patent teaches how to generate cartilage through the growth of chondrocyte stem cells under shear stress. It is believed that the sheer stress activates certain mechanoreceptors which cause appropriate differentiation of the chondrocyte stem cells into cartilage.
Inventors: Seliktar, Dror (Atlanta, GA); Dunkelman, Noushin (San Diego, CA); Peterson, Alvin Edward (Jamul, CA); Schreiber, Ronda Elizabeth (Ramona, CA); Willoughby, Jane (Del Mar, CA); Naughton, Gail K. (Del Mar, CA)
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Wednesday November 20th, 1996
Embryonal cardiac muscle cells, their preparation and their use
Patent Number: 5928943This patent covers specific embryonically-derived cells that have stem cell ability to regenerate myocardium after injury. Methods for selecting cells with such potential are disclosed.
Inventors: Franz, Wolfgang-Michael (Gross Gronau, DE); Wobus, Anna M. (Gatersleben, DE)
Assignee: Institut fur Pflanzengenetik und Kulturpflanzenforschung (Gatersieben, DE)
Date of First Priority Issue: Tuesday November 22nd, 1994