Patents
Release and mobilization of haematopoietic cells
Patent Number: 5925568This patent teaches that the chemokines MIP-1 alpha/LD78 are capable of causing the mobilization of stem cells from the bone marrow. This patent is useful for increasing the number of circulating stem cells from a donor so that peripheral blood may be harvested for stem cells for transplantation. Additionally, mobilization may be performed in a patient with a stroke or cardiac infarct so as to...
Inventors: Comer, Michael Berisford (Oxford, GB); McCourt, Matthew John (Oxford, GB); Wood, Lars Michael (Oxford, GB); Hunter, Michael George (Oxford, GB); Edwards, Richard Mark (Oxford, GB)
Assignee: British Biotech Pharmaceuticals Limited (Oxford, GB)
Date of First Priority Issue: Tuesday June 15th, 1993
Methods of purifying hematopoietic cells using an antibody to a stem cell factor receptor
Patent Number: 5922847This patent teaches ways of purifying hematopoietic stem cells based on their expression of the marker c-kit. This marker is the receptor for the cytokine stem cell factor that was developed by Amgen.
Inventors: Broudy, Virginia C. (Seattle, WA); Lin, Nancy (Seattle, WA)
Assignee: Amgen Inc. (Thousand Oaks, CA)
Date of First Priority Issue: Friday April 5th, 1991
Ex vivo culture of stem cells
Patent Number: 5922597This patent teaches ways of increasing the number of stem cells ex vivo through a specific tissue culture cocktail that contains several cytokines but is serum-free and stromal cell-free.
Inventors: Verfaillie, Catherine M. (St. Paul, MN); McGlave, Philip B. (St. Paul, MN); Miller, Jeffrey S. (Little Canada, MN)
Assignee: Regents of the University of Minnesota (Minneapolis, MN)
Date of First Priority Issue: Tuesday November 14th, 1995
Polynucleotides encoding haemopoietic maturation factor
Patent Number: 5922572This patent covers peptide sequences from the "hematopoietic maturation factor", a protein that stimulates differentiation of hematopoietic stem cells.
Inventors: Rosen, Craig A. (Laytonsville, MD); Olsen, Henrik (Gaithersburg, MD); Adams, Mark D. (North Potomac, MD); Kirkness, Ewen (Washington, DC)
Assignee: Human Genome Sciences, Inc. (Rockville, MD)
Date of First Priority Issue: Tuesday January 25th, 1994
Apparatus and method for collecting blood from an umbilical cord
Patent Number: 5919176This patent covers a medical device for extraction of cord blood from an umbilical cord after delivery.
Inventors: Kuypers, Franciscus A. (El Cerrito, CA); Cole, Robert B. (Alamo, CA); Meyst, Richard P. (Valley Center, CA); Gorton, Lanny A. (San Diego, CA); Wright, James I. (Villa Park, CA)
Assignee: Children's Hospital Medical Center of Northern California (Oakland, CA)
Date of First Priority Issue: Tuesday May 14th, 1996
Umbilical cord blood collection
Patent Number: 5916202This patent covers a medical device that contains a special pouch for the collection of cord blood from umbilical cords after delivery.
Inventor: Haswell, John N. (Sarasota, FL)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday August 30th, 1996
Embryonic cell populations and methods to isolate such populations
Patent Number: 5914268This patent covers ways of culturing an embryoid body that is derived from embryonic stem cells, in order to generate a type of cell that gives rise to hematopoietic lineage stem cells and differentiated cells.
Inventors: Keller, Gordon M. (Denver, CO); Kennedy, Marion (Denver, CO); Choi, Kyunghee (Denver, CO); Firpo, Meri T. (Denver, CO)
Assignee: National Jewish Center for Immunology & Respiratory Medicine (Denver, CO)
Date of First Priority Issue: Monday November 21st, 1994
Formation of human bone in vivo using ceramic powder and human marrow stromal fibroblasts
Patent Number: 5914121This patent teaches how to use bone marrow stromal cells (are they similar to mesenchymal stem cells??) for generation of artificial bone. The use of various matrices, including ceramic powder is disclosed for practicing this invention.
Inventors: Robey, Pamela Gehron (Bethesda, MD); Bianco, Paolo (Rome, IT); Kuznetsov, Sergei (Bethesda, MD); Rowe, David (West Hartford, CT); Krebsbach, Paul (Bethesda, MD); Mankani, Mahesh H. (Bethesda, MD)
Assignee: The United States of America as represented by the Secretary of the (Washington, DC)
Date of First Priority Issue: Wednesday February 12th, 1997
Human hematopoietic stem cell
Patent Number: 5914108Provided are hematopoietic stem cells that are capable of reconsituting a hematopoietic system.
Inventors: Tsukamoto, Ann (Palo Alto, CA); Baum, Charles M. (Mountain View, CA); Aihara, Yukoh (Yokohama, JP); Weissman, Irving (Palo Alto, CA)
Assignee: Systemix, Inc. (Palo Alto, CA)
Date of First Priority Issue: Friday March 30th, 1990
Apparatus for extracting bone marrow
Patent Number: 5913859This patent teaches methods and discloses devices, that are useful for the extraction of bone marrow stem cells from the jawbone of a patient.
Inventor: Shapira, Ira L. (Highland Park, IL)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday July 1st, 1997