Patents
Serum free cultivation of primate embryonic stem cells
Patent Number: 7005252The use of serum in stem cell cultures impedes clinical translation since serum has batch to batch variability, as well as possibility of eliciting allergic responses, especially when fetal calf serum is used. The invention teaches how to grow embryonic stem cells without serum. Essentially the claims of the invention all cover compositions of albumin, amino acids, vitamins, minerals, at least...
Inventor: Thomson, James A (Madison, WI)
Assignee: Wisconsin Alumni Research Foundation (Madison, WI)
Date of First Priority Issue: Sunday September 3rd, 2000
Active retinoic acid-free culture medium for avian totipotent embryonic stem cells
Patent Number: 6998266This patent is directed towards the culture of avian embryonic stem cells. The patent has two independent claims. The first is a culture medium for avian embryonic stem cells comprising of FGF-2, IGF-1; at least one cytokine selected from LIF, IL-11, IL-6, CNTF, and oncostatin M (OSM)) and c-kit ligand (either mouse or avian. The second independent claim covers a method of culturing the avian...
Inventors: Samarut, Jacques (Lyons, FR); Pain, Bertrand (Lyons, FR)
Assignee: Institute National de la Recherche Agronomique (Paris, FR); Centre National de la Recherche Scientifique (CNRS) (Paris, FR); Ecole Normale Superieur de Lyon (Lyons, FR)
Date of First Priority Issue: Friday October 21st, 1994
Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis
Patent Number: 6998125Despite its title, the patent doesn't really deal with stimulation of hematopoiesis. It covers a method of immunizing a cancer pateint with tumor antigens and concurrenly inhibiting TGF-beta. It is known that TGF-beta is an immunosuppressive agent released by cancer cells. It may be that since TGF-b inhibits hematopoiesis, the inhibition of TGF-b would not only derepress the immune system in...
Inventors: Hanna, Nabil (Olivenhain, CA); Braslawsky, Gary R. (San Diego, CA); Hariharan, Kandasamy (San Diego, CA)
Assignee: Biogen IDEC Inc. (Cambridge, MA)
Date of First Priority Issue: Thursday September 18th, 1997
Propagation of human hepatocytes in non-human animals
Patent Number: 6995299This patent teaches ways of growing human hepatocytes in xenogenic hosts. This patent would be useful for using animals as "bioincubators" in order to grow organs or cells for human use. Specifically the patent has two independent claims. The first covers a model of hepatitis C in which a mammal is injected with human hepatocytes when it is in the fetal stage, thus becoming tolerized...
Inventors: Wu, George Y. (Avon, CT); Wu, Catherine H. (Avon, CT)
Assignee: University of Connecticut (Farmington, CT)
Date of First Priority Issue: Thursday February 11th, 1999
Cell-scaffold composition containing five layers
Patent Number: 6995013This invention is a 5-layer scaffold that is useful for growing cells in a bioreactor, or in vivo to produce functional vascularized organ tissue. The invention primarily deals with generation of bone tissue, but other types of tissues and organs can be generated using this scaffold. The patent has 1 independent claim which covers the composition of the scaffold. The assignee, Biomed...
Inventors: Connelly, Patrick R. (Rochester, NY); Babalola, Omotunde M. (Long Island, NY)
Assignee: BioMed Solutions, LLC (West Henrietta, NY)
Date of First Priority Issue: Wednesday August 7th, 2002
Method of isolating stem cells
Patent Number: 6991897This and patent #5,876,956 are licensed to the company Aldagen (2810 Meridian Parkway Suite 148 Durham, NC 27713 919-484-2571) that is actually purifying stem cells using this method for clinical trials (for example: Intramyocardial Injection of Autologous Aldehyde Dehydrogenase-Bright Stem Cells for Therapeutic Angiogenesis at Texas Heart: Oct 5, 2006). The patent covers purifying stem cells...
Inventors: Smith, Clayton A. (Tampa, FL); Colvin, Michael (Chapel Hill, NC); Storms, Robert W. (Durham, NC); Ludeman, Susan M. (Durham, NC)
Assignee: Duke University (Durham, NC)
Date of First Priority Issue: Sunday July 12th, 1998
Physiological tissue repair and functional organ regeneration by cultivation of regenerative stem cells in vivo and in situ
Patent Number: 6991813This patent covers a way of stimulating healing by treatment with a neutraceutical. Specifically the patent has 1 independent claim covering a method for regenerating skin through administration of a composition on a wound having beeswax a fatty acid-containing oil and a sterol compound. The patent claim is directed toward stimulation of proliferation of keratinocytes that express...
Inventor: Xu, Rongxiang (Arcadia, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Sunday January 28th, 2001
Progenitor cell preservation factors and methods for and products of their use
Patent Number: 6991794This patent is directed to the stimulation of hematopoietic stem cell proliferation by use of a lectin called FRIL. The patent has 2 independent claims. The first is directed towards a pharmaceutical composition claiming some distinct sequences that bind glycosylated flt-3. The second is directed towards treatment, using the same sequences. There is a paper published by the authors that...
Inventors: Colucci, M. Gabriella (La Jolla, CA); Chrispeels, Maarten J. (La Jolla, CA); Moore, Jeffrey G. (Kennebunkport, ME)
Assignee: ImClone Systems Incorporated (New York, NY); The Regents of the University of California (La Jolla, CA)
Date of First Priority Issue: Tuesday June 24th, 1997
Methods of preparing bone marrow stromal cells for use in gene therapy
Patent Number: 6991787This patent involves using gene-transfected bone marrow cells as a way of delivering the gene of interest to a tissue that needs it. For example, lets take stroke patients. Conceptually one could administer a therapeutic gene directly into the area of cell death, or in proximity to it, in order to prevent further cell death or to induce regeneration of neurons. This approach is complex since...
Inventors: Greenberger, Joel S. (Sewickley, PA); Hurwitz, David R. (Acton, MA)
Assignee: ALG Company (Marlborough, MA)
Date of First Priority Issue: Friday December 29th, 1995
Schwann cells originating in myeloid interstitial cells
Patent Number: 6989271Schwann cells generate myelin (insulates neuronal electrical signals [amognst other things]) and are essential for the proper function of neuronal tissue. Various neurological diseases would benefit from the ability to introduce Schwann Cells that are properly functioning. The current patent teaches ways of using bone marrow stromal cells as a source of Schwann Cells. Specifically the patent...
Inventors: Dezawa, Mari (Yokosuka, JP); Sawada, Hajime (Yokohama, JP); Takano, Masahiko (Yokohama, JP)
Assignee: Sanbio, Inc. (Mountain View, CA)
Assignee: Sanbio, Inc. (Mountain View, CA)
Date of First Priority Issue: Friday June 22nd, 2001