Patents
Method for producing a population of homozygous stem cells having a pre-selected immunotype and/or genotype, cells suitable for transplant derived therefrom, and materials and methods using same
Patent Number: 7030292This invention teaches how to generate a "cell bank" of embryonic stem cells that are homozygous at HLA. Theoretically, the inventors suggest..."that a few hundred stem cell lines that are homozygous for different haplotypes will be sufficient to match a majority of the human population. This number is tremendously smaller in contrast to the number of haplotypes needed to maintain a...
Inventors: Yan, Wen Liang (Potomac, MD); Huang, Steve Chien-Wen (Germantown, MD); Nguyen, Minh-Thanh (Rockville, MD); Lin, Huan (Helen) (N. Potomac, MD); Lei, Jingqi (Gaithersburg, MD); Khanna, Ruchi (Germantown, MD)
Assignee: Stemron, Inc. (Myersville, MD)
Date of First Priority Issue: Thursday February 1st, 2001
Method for differentiating rat hepatic stem cells to insulin-producing cells
Patent Number: 7029915The invention teaches how to make liver stem cells into cells that resemble pancreatic endocrine cells (ie islets). The patent has 1 independent claim, basically covering a method of endowing hepatic stem cells with an endocrine pancreatic characteristic by first isolating hepatic stem cells from 2-acetylamino-fluorene-treated adult rats and then growing the cells in a medium made of >5.5 mM...
Inventor: Yang, Lijun (Gainesville, FL)
Assignee: University of Florida Research Foundation, Inc. (Gainesville, FL)
Date of First Priority Issue: Friday February 22nd, 2002
Uses for non-autologous mesenchymal stem cells
Patent Number: 7029666This patent teaches therapeutic uses of mesenchymal stem cells that are NOT MHC matched. Two specific uses seem to be covered: connective tissue regeneration, and muscle regeneration. The patent has two independent claims, the first covers a method of promoting muscle growth in a human by administration of non-MHC matched mesenchymal stem cells, whereas the second covers a method of promoting...
Inventors: Bruder, Scott P. (Waltham, MA); McIntosh, Kevin R. (Ellicott City, MD); Marshak, Daniel R. (Lutherville, MD); Mosca, Joseph D. (Ellicott City, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Friday March 13th, 1998
Method of inducing formation of kidney epithelia from mesenchymal precursors
Patent Number: 7022666This patent seems to cover the preservation of a kidney, despite its title. It may be that preservation is achieved through endogenous stem cell differentiation of kidney epithelium. The patent has one claim covering a method of preserving a kidney by contacting the kidney with a ligand for gp130 receptor (ie LIF, a cardiotrophin, a ciliary neuronotrophic factor, an interleukin-6), and a...
Inventors: Barasch, Jonathan M. (New York, NY); Oliver, Juan A. (New York, NY); Yang, Jun (New York, NY)
Assignee: The Trustees of Columbia University in the City of New York (New York, NY)
Date of First Priority Issue: Tuesday May 4th, 1999
Use of marrow-derived glial progenitor cells as gene delivery vehicles into the central nervous system
Patent Number: 7022321This patent capitalizes on the ability of bone marrow cells to migrate into the brain and cause repairative function. The patent uses bone marrow cells as a "vector" in order to deliver glial cell line-derived neurotrophic factor (GDNF) to the area of need. The patent has 2 independent claims both covering "A method of treating Parkinson's disease, ". The first covers administration of bone...
Inventors: Eglitis, Martin A. (Indianapolis, IN); Mezey, Eva (Rockville, MD); Mouradian, Mary Maral (Bethesda, MD)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Saturday October 4th, 1997
Method of detecting hematopoietic progenitor cells
Patent Number: RE39,006This patent appears to cover a new method of detecting hematopoietic stem cells, without needing to use stem cell-specific markers. The patent seems to use some light and physical properties of the cells to distinguish between stem cells and non-stem cells. The patent has one issued claim which is: "A method for detecting or counting or both detecting and counting hematopoietic progenitor...
Inventors: Houwen, Berend (Redlands, CA); Tsujino, Yukio (Hyogo-ken, JP); Morikawa, Takashi (Hyogo-ken, JP); Ikeuchi, Yoshiro (Hyogo-ken, JP); Hamaguchi, Yukio (Hyogo-ken, JP); Wang, Fu-sheng (Hyogo, JP); Hirai, Kojiro (Hyogo, JP)
Assignee: Sysmex Corporation (Kobe, JP)
Date of First Priority Issue: Saturday March 1st, 1997
Multiponent adult stem cells and methods for isolation
Patent Number: 7015037This patent describes a bone marrow stem cell population that is multipotent and capable of differentiating into various lineages besides hematopoietic ones. Specifically, the patent has 5 independent claims, all covering a stem cell isolated from bone marrow. The first covers a CD49c and CD90 postive cell that doubles around every 36 hours. The second covers a cell of similar phenotype that...
Inventors: Furcht, Leo T. (Minneapolis, MN); Verfaillie, Catherine M. (St. Paul, MN); Reyes, Morayma (Minneapolis, MN)
Assignee: Regents of the University of Minnesota (Minneapolis, MN); MCL/LLC (Minneapolis, MN)
Date of First Priority Issue: Saturday May 8th, 1999
Implanting neural progenitor cells derived for human embryonic stem cells
Patent Number: 7011828This patent is a owned by the embryonic stem cell powerhouse, ES International from Singapore. The patent covers a method of administration of embryonic stem cells that have been differentiated into neuron-like cells. The invention contains one independent claim, specifically covering: "a method of administration of stem cell derived neural progenitors" but the neural progenitors are...
Inventors: Reubinoff, Benjamin Eithan (Elsternwick, AU); Pera, Martin Frederick (Prahran, AU); Ben-Hur, Tamir (Jerusalem, IL)
Assignee: ES Cell International Pte. Ltd. (Singapore, SG)
Date of First Priority Issue: Wednesday March 14th, 2001
Compositions and methods for producing and using homogenous neuronal cell transplants
Patent Number: 7011827This patent covers the use of the human NT2N neurons for treatment of brain injury. Essentially, the NT2N cells are a cell line derived from a human teratocarcinoma which have neuronal properties., specifically, the cells are post-mitotic since the original teratocarcinoma cell is induced to differentiate into neurons which retinoic acid...this way tumors are not suppose to form in the...
Inventors: Lee, Virginia M.-Y. (Philadelphia, PA); Trojanowski, John Q. (Philadelphia, PA)
Assignee: Trustees of the University of Pennsylvania (Philadelphia, PA)
Date of First Priority Issue: Saturday September 11th, 1993
System and method for processing bone marrow
Patent Number: 7008394Bone marrow transplants, as well as other bone marrow applications represent by far the largest use of stem cells in medicine. The process of harvesting bone marrow may be complicated and prone to contamination. Since bone marrow harvest is a painful and almost traumatic procedure, contamination of a bone marrow graft during harvest could be disasterous. The current invention teaches the use of...
Inventors: Geise, Russell D. (Allentown, PA); Chapolini, Robert J. (Phoenix, MD)
Assignee: BioAccess, Inc. (Baltimore, MD)
Date of First Priority Issue: Thursday March 29th, 2001