Patents
Methods to mobilize progenitor/stem cells
Patent Number: 6987102Hematopoietic stem cells stay in the bone marrow due in part to secretion of SDF-1 by bone marrow stromal cells. The chemotactic gradient of SDF-1 is also what causes hematopoietic stem cells to home to the bone marrow of the recipient after a bone marrow transplant. This invention covers some antagonists of the receptor for SDF-1, CXCR-4 which when administered cause the stem cell cells to...
Inventors: Bridger, Gary J. (Bellingham, WA); Abrams, Michael J. (Custer, WA); Henson, Geoffrey W. (Ferndale, WA); MacFarland, Ronald Trevor (Vancouver, CA); Calandra, Gary B. (Cresco, PA); Broxmeyer, Hal E. (Indianapolis, IN); Dale, David C. (Seattle, WA)
Assignee: Anormed, Inc. (Langley, CA)
Date of First Priority Issue: Tuesday July 31st, 2001
Human ovarian mesothelial cells and methods of isolation and uses thereof
Patent Number: 6987024This patent covers a new type of ovarian progenitor cell. Specifically, the patent has 1 independent claim covering a cell population that can differentiate into overian epithelium or granulosa cells. Two other claims that appear to be of high importance are the use of this cell for production of proteins, and the use of this cell for bioassays.
Inventors: Li, Rong-hao (La Jolla, CA); Bald, Laura (Los Altos, CA); Mather, Jennie Powell (Millbrae, CA)
Assignee: Raven Biotechnologies, Inc. (South San Francisco, CA)
Date of First Priority Issue: Wednesday October 4th, 2000
Universal stem cells
Patent Number: 6986887This patent teaches how to make stem cells less immunogenic by modification of the human leukocyte antigen content. Specifically the patent has 2 independent claims. The first covers modification of HLA-B and HLA-C, whereas the second covers modification of HLA-DR. Essentially the generation of "universal donor" stem cells can be made in such a manner by making the cells more compatible...
Inventors: Lawman, Patricia (Chipley, FL); Lawman, Michael J. P. (Chipley, FL)
Assignee: Morphogenesis, Inc. (Oldsmar, FL)
Date of First Priority Issue: Tuesday March 25th, 1997
Isolation and use of solid tumor stem cells
Patent Number: 6984522In the cancer patient it is believed that tumors are actually a heterogeneous population of cells, and that not all the tumor cells have equal proliferative capability. This concept of the "tumor stem cell" maintaining the bulk of the tumor population is very important since many believe that the cells targeted by conventional therapies are not the actual tumor stem cell but derivatives thereof...
Inventors: Clarke, Michael F. (Ann Arbor, MI); Morrison, Sean J. (Ann Arbor, MI); Wicha, Max S. (Ann Arbor, MI); Al-Hajj, Muhammad (Ann Arbor, MI)
Assignee: Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Wednesday March 8th, 2000
Gene therapy by administration of genetically engineered CD34.sup.+ cells obtained from cord blood
Patent Number: 6984379This patent covers the use of autologous cord blood CD34 cells transfected with the adenosine deaminase gene for the treatment of severe combined immunodeficiency (SCID). The patent has 3 independent claims, the first covering a method of expressing a therapeutic agent in a human (but specifically restricted to adenosine deaminase), the second a method of treating a human with SCID, and the...
Inventors: Kohn, Donald B. (Tarzana, CA); Blaese, R. Michael (Rockville, MD); Mullen, Craig A. (Sugar Land, TX); Moen, Robert C. (Mountain View, CA)
Assignee: Children's Hospital of LosAngeles (LosAngeles, CA); The United States of America as represented by the Department of Health and Human Services
Date of First Priority Issue: Thursday August 4th, 1994
Bone marrow aspiration system
Patent Number: 6981948As mentioned in our discussion about patent # 7008394, bone marrow harvesting is a relatively invasive procedure. This is also very relavant for regenerative uses of bone marrow where patients with a heart attack or stroke are harvested. Accordingly there is a need to develop less invasive and increasingly sterile means of harvesting. The current patent has two independent claims covering a...
Inventors: Pellegrino, Richard C. (Mendon, MA); Voellmicke, John C. (Cumberland, RI)
Assignee: DePuy Spine, Inc. (Raynham, MA)
Date of First Priority Issue: Monday November 18th, 2002
Isolated stromal cells and methods of using the same
Patent Number: 6974571The invention covers a way of introducing stem cells into a host in such a manner that the cells can be killed off if desired through administration of an agent that induces expression of a suicide gene. This is important since in some situations it is desired to have the exogenous stem cells in the body only for a limited period of time. Specifically, the invention has 2 independent claims...
Inventors: Prockop, Darwin J. (Philadelphia, PA); Pereira, Ruth F. (Lansdowne, PA); Leeper, Dennis B. (Wynnewood, PA); O'Hara, Michael D. (Wyncote, PA); Kulkosky, Joseph (Philadelphia, PA); Phinney, Donald (Maple Glen, PA); Laptev, Alexey (Philadelphia, PA)
Assignee: Thomas Jefferson University (Philadelphia, PA)
Date of First Priority Issue: Tuesday March 28th, 1995
Composition and method for culturing potentially regenerative cells and functional tissue-organs in vitro
Patent Number: 6972195This patent teaches the composition of a culture media that is shown in the EXAMPLES section useful for growing: Human Intestinal Cells, Mouse Intestinal Mucosal Villi, Mouse Bone Marrow Tissue , Rat Nerve Tissue, Mouse Pancreatic Cells, Mouse Renal Cells, Human Hair Follicles, Rat Cardiomuscular Cells, Rat Thymocytes , and Rat Hepatocytes. The examples also show activity of the media in...
Inventor: Xu, Rongxiang (Arcadia, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday December 31st, 2002
Materials and methods for nerve grafting, selection of nerve grafts, and in vitro nerve tissue culture
Patent Number: 6972168This patent teaches ways of generating an plethora of compounds which are useful for regeneration of damaged nervous system tissue. Specifically, the patent has 2 independent claims. The first covers growing nerves in conditions that are not associated with degeneration, then killing the nerves, harvesting the material, and introducing the material into an area where damaged neurons are present...
Inventor: Muir, David F. (Gainesville, FL)
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Assignee: University of Florida Research Foundation, Incorporated (Gainesville, FL
Date of First Priority Issue: Monday August 13th, 2001
Compounds and methods for increasing neurogenesis
Patent Number: 6969702This patent deals with administration of compounds, some which I believe are already in the clinic, for stimulation of neurogenesis in a patient suffering from a neurodegenerative condition. The patent has 2 independent claims, the first covers the administration of calcitonin, or exendin or analogues thereof that intracellular cAMP levels. The second independent claim covers administration of...
Inventors: Bertilsson, Goran (Vasterhaninge, SE); Erlandsson, Rikard (Sundyberg, SE); Frisen, Jonas (Stockholm, SE); Haegerstrand, Anders (Danderyd, SE); Heidrich, Jessica (.ANG.rsta, SE); Hellstrom, Nina (Sodertalje, SE); Haggblad, Johan (Vastgotagrand, SE); Jansso
Assignee: NeuroNova AB (Stockholm, SE)
Date of First Priority Issue: Wednesday November 20th, 2002
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