Patents
Human pluripotent hematopoietic colony stimulating factor, method of production and use
Patent Number: 6838549This is a patent for a hematopoietic stimulatory cytokine that the inventors named pluripoietin alpha. This cytokine is described in several papers including (Gabrilove et al. Pluripoietin : A Second Human Hematopoietic Colony-Stimulating Factor Produced by the Human Bladder Carcinoma Cell Line 5637, PNAS | April 15, 1986 | vol. 83 | no. 8 | 2478-2482). This factor is produced by several cell...
Inventors: Welte, Karl (New York, NY); Platzer, Erich (Spardorf, DE); Gabrilove, Janice L. (New York, NY); Mertelsmann, Roland (Mainz, DE); Moore, Malcolm A. S. (Larchmont, NY)
Assignee: Sloan-Kettering Institute for Cancer Research (New York, NY)
Date of First Priority Issue: Thursday March 28th, 1985
Cell culture medium containing growth factors and L-glutamine
Patent Number: 6838284This is a patent for a specific type of tissue culture media that may be used for growth and expansion of various stem cells. The media contains combinations of various factors such as anti-oxidants, nutrients, and growth factors. This patent may be useful not only for laboratory reagents but as a basis for developing cellular therapy media for ex vivo expansion in a GMP setting.
Inventors: de Bruijn, Joost Dick (Amersfoort, NL); Tibbe, Gerhardus Johannes M. (Amersfoort, NL); da Silva Madureira Mendes, Sandra Claudia (Gouda, NL)
Assignee: IsoTis N.V. (Bilthoven, NL)
Date of First Priority Issue: Tuesday December 28th, 1999
Antibody recognizing a small subset of human hematopoietic cells
Patent Number: 6838282This is a patent for a unique stem cell marker that is recognized by the antibody MG-1. There are numerous stem cell markers in existence which are used for isolation of stem cell subtypes. The value of new stem cell markers is relatively high since the field is very populated. A patent such as the present one, if MG-1 has not been commercialized, can be used to position a new biotech...
Inventors: Lawman, Michael J. P. (Chipley, FL); Lawman, Patricia (Chipley, FL)
Assignee: Morphogenesis, Inc. (Chipley, FL)
Date of First Priority Issue: Wednesday November 13th, 1996
Methods for using the obese product to stimulate hematopoietic development
Patent Number: 6838079Leptin is a natural inhibitor of fat. When you knock out leptin gene, mice are extremely obese. Interestingly, leptin has numerous other functions in the body, including stimulation of inflammatory responses, as well as immunologically predisposing to Th1. In this patent the inventors identified that leptin stimulates hematopoiesis. This patent may be useful for treatment of...
Inventors: Snodgrass, H. Ralph (Powell, OH); Cioffi, Joseph (New Albany, OH); Zupancic, Thomas Joel (Worthington, OH); Shafer, Alan Wayne (Lancaster, OH)
Assignee: Indevus Pharmaceuticals, Inc. (Lexington, MA)
Date of First Priority Issue: Wednesday September 14th, 1994
Method and apparatus for sorting biological cells with a MEMS device
Patent Number: 6838056This patent covers a medical device that is useful for purifying hematopoietic stem cells. The medical device selects stem cells but not contaminating cancer cells, and is therefore useful for treatment of cancer patients by purifying autologous stem cells before high dose chemotherapy so that the stem cells can be re-introduced in order to accelerate reconstitution of hematopoiesis.
Inventor: Foster, John Stuart (Santa Barbara, CA)
Assignee: Innovative Micro Technology (Goleta, CA)
Date of First Priority Issue: Saturday June 8th, 2002
Thrombopoietic compounds
Patent Number: 6835809This patent covers a peptide that stimulates stem cells to differentiate into the megakaryocytic lineage. This patent is useful for acceleration of platelet recovery after chemotherapy, radiation therapy, or bone marrow transplant. Since thrombopoietin stimulates early stem cells to self-renew, it may be interesting to see if this peptide also has similar activities.
Inventors: Liu, Chuan-Fa (Longmont, CO); Feige, Ulrich (Newbury Park, CA); Cheetham, Janet C. (Montecito, CA)
Assignee: Amgen Inc. (Thousand Oaks, CA)
Date of First Priority Issue: Friday October 23rd, 1998
Human lineage committed cell composition with enhanced proliferative potential, biological effector function, or both; methods for obtaining same; and their uses
Patent Number: 6835566This patent teaches the generation of lineage-committed dendritic cell progenitors. This is important since the dendritic cell is a master controller of the immune response, being able to both stimulate responses as well as inhibit them. Dendritic cells can be made to stimulate responses through activation with various cytokines or toll like receptors, whereas they can also suppress responses...
Inventors: Smith, Alan K. (Saline, MI); Smith, Douglas M. (Ann Arbor, MI); Mandalam, Ramkumar K. (Westland, MI)
Assignee: Aastrom Biosciences, Inc. (Ann Arbor, MI)
Date of First Priority Issue: Monday February 23rd, 1998
Making neural cells for human therapy or drug screening from human embryonic stem cells
Patent Number: 6833269Despite all the publicity of embryonic stem cell therapy, the fact that embryonic stem cells turn into cancer cells when inserted into a living organism suggests the very import need to understand and develop ways of manipulating them to differentiate into the tissue that is needed to be repaired. This patent teaches conditions for generating neural cells from embryonic stem cells through...
Inventor: Carpenter, Melissa K. (Castro Valley, CA)
Assignee: Geron Corporation (Menlo Park, CA)
Date of First Priority Issue: Wednesday May 17th, 2000
Common neural progenitor for the CNS and PNS
Patent Number: 6830927This patent teaches how to generate neuronal stem cells that are bipotent into differentiating into central nervous system neurons as well as peripheral nervous system neurons. The patent uses neuronal stem cells that are extracted from specific parts of the embryo and cultured in fibroblast growth factor and chicken embryo extract. Besides the intrinsic value of composition of matter on...
Inventors: Rao, Mahendra S. (Salt Lake City, UT); Mujtaba, Tahmina (Sandy, UT)
Assignee: University of Utah Research Foundation (Salt Lake City, UT
Date of First Priority Issue: Wednesday May 7th, 1997
Method for the isolation of stem cells by immuno-labeling with HLA/MHC gene product marker
Patent Number: 6828145Classically hematopoietic stem cells are purified based on expression of markers such CD34 or c-kit. This patent teaches that hematopoietic stem cells can also be further purified by selecting cells that lack expression of MHC I. The lack of expression of class I may have to do with the presumed weaker immunogenecity of hematopoietic stem cells. Currently this invention doesnt seem to be...
Inventors: Avital, Itzhak (Los Angeles, CA); Arnaout, Walid (Calabasas, CA); Inderbitzin, Daniel (Zurich, CH)
Assignee: Cedars-Sinai Medical Center (Los Angeles, CA)
Date of First Priority Issue: Wednesday May 10th, 2000