Patents
Therapeutic and diagnostic methods and compositions based on Jagged/Notch proteins and nucleic acids
Patent Number: 6825007This patent covers composition of matter of Jagged 1, as well as its use in stem cell expansion. This patent is useful not only for classical regenerative applications, but also for stimulating production of special immune system cells.
Inventors: Zimrin, Ann B. (Marriottsville, MD); Maciag, Thomas (Freeport, ME); Pepper, Michael S. (Geneva, CH); Montesano, Roberto (Geneva, CH); Wong, Michael (Derwood, MD)
Assignee: Maine Medical Center Research Institute (Scarborough, ME)
Date of First Priority Issue: Friday May 31st, 1996
Methods for storing neural cells
Patent Number: 6821779This patent covers methods of storing neural stem cells and neural cells that have been differentiated from stem cells. This patent covers not only human but also porcine cells. The assignee company was at one time performing clinical trials with encapsulated porcine neural cells in patients.
Inventors: Koopmans, Jan (Groningen, NL); Jacoby, Douglas B. (Wellesley, MA); Dinsmore, Jonathan (Brookline, MA)
Assignee: University Hospital Groningen, Inc. (Groningen, NL); Diacrin, Inc. (Charlestown, MA)
Date of First Priority Issue: Monday July 6th, 1998
Method for enhancing hematopoiesis
Patent Number: 6821513Inventor: Fleming, William H. (Portland, OR)
Assignee: Oregon Health & Science University (Portland, OR)
Date of First Priority Issue: Wednesday June 23rd, 1999
Methods of creating constructs useful for introducing sequences into embryonic stem cells
Patent Number: 6815185This patent provides methods and vectors for transfection of embryonic stem cells. This patent is useful for generation of various animal research models that have a genetic modification introduced into the whole animal. Additionally, transfection of embryonic stem cells could be useful for a variety of different things, including using the embryonic stem cells as a vector...or in another...
Inventors: Klein, Robert D. (Palo Alto, CA); Brennan, Thomas J. (South San Francisco, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Monday November 17th, 1997
Myocardial grafts and cellular compositions useful for same
Patent Number: 6818210This patent teaches how to generate a myocardial graft using embryonic stem cells that have been induced to differentiate into the cardiac lineage. This patent is especially useful for post myocardial infarction in which scar tissue replaces functional myocardium resulting in decreased cardiac output. Numerous methods have been previously described for generation of myocardial cells from...
Inventor: Field, Loren J. (Indianapolis, IN)
Assignee: Advanced Research & Technology Institute (Indianapolis, IN)
Date of First Priority Issue: Tuesday November 16th, 1993
Methods of making pancreatic islet cells
Patent Number: 6815203This patent teaches ways of dedifferentiating pancreatic duct or exocrine cells and then redifferentiating the cells to generate functional islet cells. This patent is especially relevant in light of the Edmonton Protocol that provides methods of transplanting allogeneic pancreatic islets. The problem with the Edmonton Protocol is that it takes up to 2, sometimes even more pancreas's for 1...
Inventors: Bonner-Weir, Susan (Cambridge, MA); Taneja, Monica (Bronx, NY)
Assignee: Joslin Diabetes Center, Inc. (Boston, MA)
Date of First Priority Issue: Wednesday June 23rd, 1999
Method for enhancing stem cell trafficking
Patent Number: 6814961This patent teaches the use of a naturopathic remedy for actually mobilizing stem cells into systemic circulation. The naturopathic remedy is blue green algae. This patent may be used for treating anything that benefits from mobilized stem cells ranging from stroke to myocardial infarction.
Inventors: Jensen, Gitte S. (Port Dover, Ontario, CA); Drapeau, Christian (Keno, OR)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Monday May 14th, 2001
Process for ex vivo formation of mammalian bone and uses thereof
Patent Number: 6811776This patent teaches how to use bone stem cells, or bone precursor cells in order to generate in vitro bones that can be subsequently introduced in vivo. The invention is of use to any biotech interested in entering the regenerative market in the area of osteogenesis.
Inventors: Kale, Sujata (Boston, MA); Long, Michael W. (Northville, MI)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Wednesday December 27th, 2000
Method for generating immune-compatible cells and tissues using nuclear transfer techniques
Patent Number: 6808704This patent teaches methods of generating stem cells using cloning that match the potential recipient according to HLA phenotype. This patent could be very useful since in essence it describes a method of making stem cells that will not be rejected by the immune system.
Inventors: Lanza, Robert (Clinton, MA); West, Michael D. (Boston, MA); Cibelli, Jose (Holden, MA)
Assignee: Advance Cell Technology, Inc. (Worcester, MA)
Date of First Priority Issue: Tuesday September 7th, 1999
Treatment of disorders by implanting stem cells and/or progeny thereof into gastrointestinal organs
Patent Number: 6808702This patent is very interesting in that it provides a source of nitric oxide through the use of fetal and embryonically derived neural stem cells. The neural stem cells can be administered by various means in order to correct gastrointestinal deficiencies.
Inventors: Pasricha, Pankaj J. (Houston, TX); Micci, Maria A. (Dickinson, TX)
Assignee: Board of Regents, the University of Texas System (Austin, TX)
Date of First Priority Issue: Thursday April 13th, 2000