Patents
Histone deacetylases, and uses related thereto
Patent Number: 6777217This patent appears to be a composition of matter patent on various histone deacetylases. These proteins, histone deacetylases, are very important in controlling gene expression. Typically histone deacetylases suppress gene expression by deacetylazing histones, which control large parts of the DNA. Since histone deacetylase inhibitors actually stimulate expression of genes that are normally...
Inventors: Schreiber, Stuart L. (Boston, MA); Taunton, Jack (Somerville, MA); Hassig, Christian A. (Somerville, MA); Jamison, Timothy F. (Cambridge, MA)
Assignee: President and Fellows of Harvard College (Cambridge, MA)
Date of First Priority Issue: Tuesday March 26th, 1996
Method and system for myocardial infarction repair
Patent Number: 6775574This patent covers the implantation of a stem cell source, or genes associated with stem cells and regeneration, together with a pace-maker type device, into a patient whose heart is in need of regeneration. The advantage of this patent is that numerous times the implanted cells do not beat in synchronism with the host cardiac cells, this patent tries to overcome this problem.
Inventors: Soykan, Orhan (New Brighton, MN); Donovan, Maura G. (St. Paul, MN)
Assignee: Medtronic, Inc. (Minneapolis, MN)
Date of First Priority Issue: Friday November 7th, 1997
Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
Patent Number: 6774120This patent teaches how to make liver cells behave like pancreatic cells and even offers the possibility of treating type 1 diabetes. Essentially the patent claims that by transfecting liver cells with the pancreatic stem cell transcription factor PDX-1, the liver cells will start producing insulin (besides other things).
Inventor: Ferber, Sarah (Ramat Hasharon, IL)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday April 19th, 2000
Injection molding of living tissues
Patent Number: 6773713This patent teaches how to combine computer engineering design tools together with stem cell technologies for the formation of 3 dimensional tissues that may subsequently be implanted.
Inventors: Bonassar, Lawrence J. (Acton, MA); Rowley, Jon A. (Chapel Hill, NC); Mooney, David J. (Ann Arbor, MI)
Assignee: University of Massachusetts (Boston, MA)
Date of First Priority Issue: Friday February 23rd, 2001
Container for biological products requiring cellular stasis
Patent Number: 6773425This patent discloses various vessels and uses thereof that can be used to store stem cells and other biological products during transportation.
Inventor: Tamari, Yehuda (Oyster Bay, NY)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday December 29th, 2000
Hematopoietic stimulation
Patent Number: 6770628This patent takes a new twist on stimulation of hematopoietic stem cells. It uses inhibitors of Dipeptidyl Peptidase IV, an enzyme that destroys hematopoietic growth factors, in order to "suppress the suppressor".
Inventors: Wallner, Barbara P. (Weston, MA); Jones, Barry (Cambridge, MA); Miller, Glenn T. (Haverhill, MA); Adams, Sharlene (Watertown, MA)
Assignee: Point Therapeutics, Inc. (Boston, MA)
Date of First Priority Issue: Monday May 4th, 1998
Erythrocytic cells and method for preserving cells
Patent Number: 6770478This patent covers methods of preserving red blood cells through cryopreservation. The method involves depletion of cholesterol and loading of the cells with an oligosaccharide. Cryopreservation according to this method may be performed in stem cell derived erythrocytes for use in emergency situations.
Inventors: Crowe, John H. (Davis, CA); Crowe, Lois M. (Davis, CA); Tablin, Fern (Davis, CA); Wolkers, Willem F (Davis, CA); Tsvetkova, Nelly M. (Davis, CA); Oliver, Ann F. (Davis, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Date of First Priority Issue: Thursday February 10th, 2000
Method preventing depletion of non-autologous hematopoietic cells and animal model systems for use thereof
Patent Number: 6770260This patent teaches depletion or inactivation of recipient macrophages using dichloromethylene diphosphonate in order to allow allogeneic or xenogeneic stem cell transplants and progeny of the stem cell transplants not to be rejected. The patent is very interesting since the inactivation of macrophages theoretically may also allow for inactivation of dendritic cells. If this occurs, then the...
Inventors: Chen, Ben (Fremont, CA); Fraser, Chris (Los Altos, CA); Weissman, Irv (Redwood City, CA)
Assignee: Novartis AG (Basel, CH)
Date of First Priority Issue: Friday December 17th, 1993
Mineralization and biological modification of biomaterial surfaces
Patent Number: 6767928This patent covers ways of altering biomaterials so that bone may be grown around them. Specifically useful is the application of such biomaterials as scaffolds around which stem cells can be grown in order to generate tissues that can be implanted.
Inventors: Murphy, William L. (Ann Arbor, MI); Peters, Martin C. (Ann Arbor, MI); Mooney, David J. (Ann Arbor, MI); Kohn, David H. (Ann Arbor, MI)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Friday March 19th, 1999
Stem cell and dental pulp harvesting method and apparatus
Patent Number: 6767740Teeth are known to contain various cellular populations in the pulp, including stem cells. The idea of banking tooth stem cells is limited by the ease of extraction. This patent discloses various apparatus' that are easily used for the extraction of tooth stem cells.
Inventors: Sramek, Roger Anton (Sausalito, CA); Javid, Bahram (El Cerrito, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday October 9th, 2001